中文名 | 柴胡皂苷D |
英文名 | Saikosaponin D |
别名 | 紫胡皂苷D 柴胡皂甙E 柴胡皂苷D 柴胡皂苷 D 柴胡提取物(液) 柴胡皂苷 D, 来源于柴胡 SAIKOSAPONIAN D 柴胡皂苷D SAIKOSAPONIAN D 柴胡皂苷D 标准品 |
英文别名 | saikosaponin saikosaponins Saikosaponin D SAIKOSAPONIN D Saikosaponian D sailkosaponin D SAILKOSAPONINS D (3b,4a,16a)-13,28-Epoxy-16,23-dihydroxyolean-11-en-3-yl 6-deoxy-3-O-beta-D-glucopyranosyl beta-D-galactopyranoside (3beta,16alpha)-16,23-Dihydroxy-13,28-epoxyolean-11-en-3-yl 6-deoxy-3-O-beta-D-glucopyranosyl-beta-D-galactopyranoside beta-D-galactopyranoside, (3beta,16alpha)-13,28-epoxy-16,23-dihydroxyolean-11-en-3-yl 6-deoxy-3-O-beta-D-glucopyranosyl- (3beta,13alpha,16alpha,17alpha)-16,23-dihydroxy-13,28-epoxyolean-11-en-3-yl 6-deoxy-3-O-beta-D-glucopyranosyl-beta-D-galactopyranoside |
CAS | 20874-52-6 |
化学式 | C42H68O13 |
分子量 | 780.99 |
InChI | InChI=1/C42H68O13/c1-21-28(46)33(55-34-31(49)30(48)29(47)22(18-43)53-34)32(50)35(52-21)54-27-10-11-37(4)23(38(27,5)19-44)8-12-39(6)24(37)9-13-42-25-16-36(2,3)14-15-41(25,20-51-42)26(45)17-40(39,42)7/h9,13,21-35,43-50H,8,10-12,14-20H2,1-7H3/t21-,22-,23-,24-,25-,26-,27+,28+,29-,30+,31-,32-,33+,34+,35+,37+,38+,39-,40+,41-,42+/m1/s1 |
密度 | 1.36±0.1 g/cm3(Predicted) |
熔点 | 212~218℃ |
沸点 | 893.7±65.0 °C(Predicted) |
比旋光度 | (EtOH)+37 |
闪点 | 494.3°C |
蒸汽压 | 0mmHg at 25°C |
溶解度 | 甲醇 (微溶) 、吡啶 (微溶) |
折射率 | 1.616 |
酸度系数 | 12.83±0.70(Predicted) |
存储条件 | Hygroscopic, Refrigerator, Under inert atmosphere |
稳定性 | 吸湿性 |
外观 | 固体 |
颜色 | White to Off-White |
物化性质 | 淡黄色结晶,易溶于水、稀醇,难溶于苯、乙醚、氯仿,来源于柴胡地上部分。 |
MDL号 | MFCD09028095 |
安全术语 | 24/25 - 避免与皮肤和眼睛接触。 |
RTECS | VN3099000 |
海关编号 | 29389090 |
下游产品 | 柴胡皂甙元 D |
参考资料 展开查看 | 1. 程玉鹏, 王洪月, 高宁,等. 柴胡与其内生真菌共培养的内生真菌中柴胡总皂苷含量测定[J]. 化学工程师, 2018, v.32;No.279(12):23-25. 2. 张娜, 晏旎, 周蒙恩,等. 柴胡皂苷d对氧化应激诱导的人肝星状细胞活化后ROS形成及NLRP3炎性小体表达的影响[J]. 时珍国医国药, 2020(4):805-809. 3. 辛国 赵昕彤 李文 等. 不同时间煎煮柴胡对五柴胡饮中柴胡皂苷含量及药效学的影响[J]. 长春中医药大学学报 2018(4):641-644. 4. 宁艳梅 杨秀娟 陈晖 张金保 杨韬 任远.不同比例鳖血炮制柴胡制品中柴胡总皂苷含量测定与比较[J].中兽医医药杂志 2019 38(05):9-13. 5. 庞雪 廖念 周逸群 等. 不同炮制方法对北柴胡中柴胡皂苷含量的影响[J]. 时珍国医国药 2016(12):2906-2908. 6. 廖念 庞雪 周逸群 等. 北柴胡麸煨工艺的正交试验法优选[J]. 时珍国医国药 2017(05):96-98. 7. 李英, 焦倩, 张天天,等. 基于地形因子的河北省北柴胡生态适宜性区划研究[J]. 中国中药杂志, 2017, 042(022):4402-4407. 8. 曹雪, 蔡广知, 赵凌,等. 基于复合质量常数的北柴胡饮片等级评价[J]. 中国实验方剂学杂志, 2018(18). 9. 廖念, 庞雪, 周逸群,等. 正交试验法优选北柴胡麸炒工艺[J]. 中国药师, 2017, 020(004):738-740. 10. 赵昕彤, 辛国, 辛宇,等. 煎煮时间对柴胡中柴胡皂苷A和柴胡皂苷D含量的影响[J]. 人参研究, 2017. 11. 杨梦玲, 尤朋涛, 何丽珊,等. 基于UPLC-MS/MS分析胃溃疡模型大鼠口服加味小柴胡颗粒后血浆中8种有效成分的药代动力学[J]. 中国中药杂志, 2018, 43(18). 12. 敏,王猛猛,吴雨,陈文文,王之通,张磊阳,蒋健.补中益气汤6个成分在大鼠体内的药代动力学研究[J].辽宁中医杂志,2020,47(11):159-163. 13. Tian D-D, Wang W, Wang H-N, Sze SCW, Zhang Z-J. Pharmacokinetic Evaluation of Clozapine in Concomitant Use of Radix Rehmanniae, Fructus Schisandrae, Radix Bupleuri, or Fructus Gardeniae in Rats. Molecules. 2016; 21(6):696. https://doi.org/10.3390/molecules 14. Wang, Wei, Dan-Dan Tian, and Zhang-Jin Zhang. "In Vitro Effects of Concomitant Use of Herbal Preparations on Cytochrome P450s Involved in Clozapine Metabolism." Molecules 21.5 (2016): 597.https://doi.org/10.3390/molecules21050597 15. [IF=4.411] Wei Wang et al."In Vitro Effects of Concomitant Use of Herbal Preparations on Cytochrome P450s Involved in Clozapine Metabolism."Molecules. 2016 May;21(5):597 16. [IF=4.411] Dan-Dan Tian et al."Pharmacokinetic Evaluation of Clozapine in Concomitant Use of Radix Rehmanniae, Fructus Schisandrae, Radix Bupleuri, or Fructus Gardeniae in Rats."Molecules. 2016 Jun;21(6):696 17. [IF=4.396] Xiaoman Chen et al."Synergetic and Antagonistic Molecular Effects Mediated by the Feedback Loop of p53 and JNK between Saikosaponin D and SP600125 on Lung Cancer A549 Cells."Mol Pharmaceut. 2018;15(11):4974–4984 18. [IF=3.396] Shi Weiwei et al."Saikosaponin-d inhibits proliferation by up-regulating autophagy via the CaMKKβ–AMPK–mTOR pathway in ADPKD cells."Mol Cell Biochem. 2018 Dec;449(1):219-226 19. [IF=3.205] Min He et al."Simultaneous determination of multiple bioactive components of Bu-zhong-yi-qi-tang in rat tissues by LC–MS/MS: Application to a tissue distribution study."J Chromatogr B. 2017 Feb;1044-1045:177 20. [IF=5.81] Cui Lihua et al."Chaihu Guizhi Ganjiang Decoction Ameliorates Pancreatic Fibrosis via JNK/mTOR Signaling Pathway."Front Pharmacol. 2021 Jun;0:1369 21. [IF=4.36] Xiaojing Zhang et al."A new discovery: Total Bupleurum saponin extracts can inhibit the proliferation and induce apoptosis of colon cancer cells by regulating the PI3K/Akt/mTOR pathway."J Ethnopharmacol. 2022 Jan;283:114742 22. [IF=3.375] Tian Gao et al."Use of Saikosaponin D and JNK inhibitor SP600125, alone or in combination, inhibits malignant properties of human osteosarcoma U2 cells."Am J Transl Res. 2019; 11(4): 2070–2080 23. [IF=3.337] Mengru Lai et al."Saikosaponin D Inhibits Proliferation and Promotes Apoptosis Through Activation of MKK4–JNK Signaling Pathway in Pancreatic Cancer Cells."Oncotargets Ther. 2020; 13: 9465–9479 24. [IF=3.205] Jie Tang et al."Metabolite profiling of Shuganzhi tablets in rats and pharmacokinetics study of four bioactive compounds with liquid chromatography combined with electrospray ionization tandem mass spectrometry."J Chromatogr B. 2021 Aug;1179:122827 25. [IF=3] Qu Lala et al."Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay."N-S Arch Pharmacol. 2020 Jun;393(6):937-950 26. [IF=2.45] Li Shengyun et al."Establishment and Application of a Method for the Determination of Ganoderic Acid A."J Food Quality. 2020;2020:6621853 27. [IF=3.911] Du Jikun et al."Saikosaponin-D Mitigates Oxidation in SH-SY5Y Cells Stimulated by Glutamate Through Activation of Nrf2 Pathway: Involvement of PI3K."Neurotox Res. 2022 Jan;:1-11 |
微信搜索化工百科或扫描下方二维码,添加化工百科小程序,随时随地查信息!