中文名 | 榄香酮酸 |
英文名 | elemonic acid |
别名 | 榄香酮酸 Β榄香酮酸 Β-榄香酮酸 Β-岚香酮酸 Β-榄香酮酸标准品 BETA-岚香酮酸 Β-岚香酮酸, 来源于橄榄 |
英文别名 | Beta-EleMonic elemonic acid β-deMonic acid β-Elemonic Acid Β-ELEMONIC ACID B-ELEMONIC ACID Elemadienonic acid BETA-ELEMONIC ACID 3-OXOTIRUCALLA-8,24-DIEN-21-OIC ACID (13α,14β,17α,20S)-3-Oxolanosta-8,24-dien-21-oic acid |
CAS | 28282-25-9 |
EINECS | 300-005-5 |
化学式 | C30H46O3 |
分子量 | 454.68 |
密度 | 1.07 |
熔点 | 224-225°C |
沸点 | 565.2±50.0 °C(Predicted) |
比旋光度 | (CHCl3)+31 |
溶解度 | 溶于氯仿、甲醇 |
酸度系数 | 4.65±0.10(Predicted) |
存储条件 | 2-8°C |
外观 | 白色晶体 |
物化性质 | 白色结晶粉末,可溶于甲醇、乙醇、DMSO等有机溶剂,来源于乳香。 |
MDL号 | MFCD00467083 |
体外研究 | β-elemonic acid (1, 3, 10, 20 µM; 24 hours) strongly induces human A549 lung cancer cell apoptosis in a dose- and time-dependent manner. β-elemonic acid (1, 3, 10, 20 µM; 24 hours) exerts potent cytotoxic effects on human NSCLC A549 cells in a dose-dependent manner. The IC 50 value following a 24-h exposure to β-elemonic acid was 6.92 µM. β-elemonic acid (20 µM; 24 hours) results in a cell percentage of 58.01% in the G0/G1 phase. β-elemonic acid (1, 3, 10, 20 µM; 24 hours) inhibits phosphorylation of p42/44, MAPK/JNK and p38 in the A549 cells. |
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