氧化芍药苷
羟基芍药苷([(1aR,2S,5R,5aR,5bS)-1a-(beta-D-glucopyranosyloxy)-5-hydroxy-2-methyltetrahydro-1H-2,5-methano-3,4-dioxacyclobuta[cd]pentalen-5b(3aH)-yl]methyl 4-hydroxybenzoate)
CAS: 39011-91-1
化学式: C23H28O12
| 中文名 | 羟基芍药苷 |
| 英文名 | [(1aR,2S,5R,5aR,5bS)-1a-(beta-D-glucopyranosyloxy)-5-hydroxy-2-methyltetrahydro-1H-2,5-methano-3,4-dioxacyclobuta[cd]pentalen-5b(3aH)-yl]methyl 4-hydroxybenzoate |
| 别名 | 羟基芍药苷 氧化芍药苷 氧化芍药苷(标准品) 羟基芍药苷(氧化芍药苷) 氧化芍药苷(羟基芍药苷)对照品, 氧化芍药苷,羟基芍药苷(标准品) OXYPAEONIFLORIN 氧化芍药苷 |
| 英文别名 | Nsc258310 Oxypeoniflorin oxypaeoniflora oxypaeoniflorin [1a-(hexopyranosyloxy)-5-hydroxy-2-methyltetrahydro-1H-2,5-methano-3,4-dioxacyclobuta[cd]pentalen-5b(3aH)-yl]methyl 4-hydroxybenzoate [(1aR,2S,5R,5aR,5bS)-1a-(beta-D-glucopyranosyloxy)-5-hydroxy-2-methyltetrahydro-1H-2,5-methano-3,4-dioxacyclobuta[cd]pentalen-5b(3aH)-yl]methyl 4-hydroxybenzoate β-D-Glucopyranoside, (1aR,2S,3aR,5R,5aR,5bS)-tetrahydro-5-hydroxy-5b-[[(4-hydroxybenzoyl)oxy]methyl]-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta[cd]pentalen-1a(2H)-yl [[(1aR)-3aβ,5,5aβ,5b-Tetrahydro-5β-hydroxy-5bβ-[[(4-hydroxybenzoyl)oxy]methyl]-2-methyl-2α,5-methano-3,4-dioxa-1H-cyclobuta[cd]pentalen]-1aβ(2H)-yl]β-D-glucopyranoside ((2S,2aR,2a1S,3aR,4R,5aR)-4-hydroxy-2-methyl-2a-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexahydro-2H-1,5-dioxa-2,4-methanocyclobuta[cd]pentalen-2a1-yl)methyl 4-hydroxybenzoate |
| CAS | 39011-91-1 |
| 化学式 | C23H28O12 |
| 分子量 | 496.46 |
| InChI | InChI=1/C23H28O12/c1-20-8-22(30)13-6-23(20,33-18-16(28)15(27)14(26)12(7-24)32-18)21(13,19(34-20)35-22)9-31-17(29)10-2-4-11(25)5-3-10/h2-5,12-16,18-19,24-28,30H,6-9H2,1H3/t12-,13-,14-,15+,16-,18+,19?,20+,21+,22-,23+/m1/s1 |
| 密度 | 1.71±0.1 g/cm3(Predicted) |
| 熔点 | >162°C (dec.) |
| 沸点 | 737.1±60.0 °C(Predicted) |
| 比旋光度 | -17.1(C=1.0，甲酸) |
| 闪点 | 254.6°C |
| 蒸汽压 | 8.22E-23mmHg at 25°C |
| 溶解度 | DMSO (微溶) 、甲醇 (微溶) |
| 折射率 | 1.707 |
| 酸度系数 | 8.16±0.15(Predicted) |
| 存储条件 | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| 稳定性 | 吸湿性 |
| 外观 | 固体 |
| 颜色 | White to Pale Yellow |
| 物化性质 | 白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于牡丹皮、芍药、赤芍。 |
| MDL号 | MFCD00869478 |
| 体外研究 | Oxypaeoniflorin (OPA; 0.1-10 µM; 8 hours) obviously reversed the hypoxia/reoxygenation (H/R)-induced decrease in cell activity and increase in apoptosis of H9c2 cells. Oxypaeoniflorin inhibits apoptosis by activating the Sirt1 (silent information regulator factor 2 related enzyme 1)/Foxo1(forkhead transcription factor FKHR) signaling pathway in myocardial tissues and H9c2 cells. Oxypaeoniflorin (0-30 μM) attenuates inflammatory effects via regulation of the toll-like receptor (TLR), extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases signaling pathways in LPS-stimulated RAW264.7 cells. |
| 参考资料 展开查看 | 1. 许源, 刘培, 严辉,等. 白芍初加工过程中单萜苷类及多羟基化合物的变化分析[J]. 中药材, 2014(5):775-780. 2. 史素影, 俞年军, 彭代银,等. 芍药根不同部位特征图谱研究[J]. 云南中医学院学报 2020年43卷1期, 12-18页, ISTIC, 2020. 3. 佘守军 郑如程 陈蕾 等. Box-Behnken响应面法优选凤丹皮中苷类成分的醇提工艺[J]. 陕西中医药大学学报 2019 042(004):21-27. 4. 佘守军 郑如程 代算算 等. 不同方法提取亳州牡丹皮中3种单萜苷的比较研究[J]. 宜春学院学报 2019(9):32-36. 5. 佘守军, 郑如程, 罗琴,等. 正交试验优化凤丹皮中单萜苷的煎煮工艺[J]. 湖北医药学院学报, 2019, 38(02):140-142. 6. 于现花 高海燕 金传山 等. 不同产地白芍标准煎液的指纹图谱及4种单萜苷类成分含量测定[J]. 中国现代应用药学 2020(11):1290-1295. 7. 张嘉嘉 马迟 朱志灵 张松柏 张勋.HPLC法同时测定白芍中5种成分含量[J].福建中医药 2019 50(01):66-67+70. 8. 王化, 何丹娆, 朱良玉,等. HPLC法同时测定赤芍中9个活性成分的含量[J]. 中草药, 2018, 049(003):708-711. 9. 梁德勤, 赵园园, 罗云,等. 不同加工方式亳白芍的高效液相指纹图谱及多成分含量比较[J]. 安徽中医药大学学报, 2018. 10. 付士朋, 沈宏伟, 王谦博,等. 赤芍饮片加工工艺的优化[J]. 中成药, 2019(8). 11. 赵园园,梁德勤,金传山,魏庆红,张伟,许凤清,王林.基于HPLC指纹图谱的亳白芍不同炮制品标准汤剂7个成分含量测定[J].天然产物研究与开发,2018,30(03):404-411+500. 12. 程江雪, 唐志书, 郭东艳, et al. 不同配伍配比对赤芍-当归药对中10个成分溶出量的影响研究[J]. 药物分析杂志, 2019, v.39(09):73-80. 13. 徐超,林杰,金传山,刘军玲.HPLC指纹图谱结合化学计量学比较同株不同生长年限亳白芍化学成分差异[J].中草药,2021,52(08):2408-2413. 14. Li-Mei Feng, Yan-Yan Chen, Ding-Qiao Xu, Rui-Jia Fu, Shi-Jun Yue, Qi Zhao, Yu-Xi Huang, Xue Bai, Mei Wang, Li-Ming Xing, Yu-Ping Tang, Jin-Ao Duan,An integrated strategy for discovering effective components of Shaoyao Gancao decoction for treating neuropa 15. Li-Mei Feng, Yan-Yan Chen, Ding-Qiao Xu, Rui-Jia Fu, Shi-Jun Yue, Qi Zhao, Yu-Xi Huang, Xue Bai, Mei Wang, Li-Ming Xing, Yu-Ping Tang, Jin-Ao Duan,An integrated strategy for discovering effective components of Shaoyao Gancao decoction for treating neuropa 16. [IF=6.576] Luo Zhiqiang et al."Mechanism of Paeoniae Radix Alba in the Treatment of Non-alcoholic Fatty Liver Disease Based on Sequential Metabolites Identification Approach, Network Pharmacology, and Binding Affinity Measurement."Front Nutr. 2021 Sep;0:674 17. [IF=5.645] Zhang-Zhen Bai et al."Comparative investigation on metabolites and biological activities of Paeonia ostii stamens from different geographical regions of China."Ind Crop Prod. 2021 Nov;172:114038 18. [IF=4.36] Qiyang Shou et al."Total glucosides of peony improve ovalbumin-induced allergic asthma by inhibiting mast cell degranulation."J Ethnopharmacol. 2019 Nov;244:112136 19. [IF=4.36] Li-Mei Feng et al."An integrated strategy for discovering effective components of Shaoyao Gancao decoction for treating neuropathic pain by the combination of partial least-squares regression and multi-index comprehensive method."J Ethnopharmacol. 2020 Oc 20. [IF=1.902] Ting Zhang et al."The influence of essential oils from ZhaLi NuSi Prescription on the pharmacokinetics of its non-volatile components in normal rats."Biomedical Chromatography. 2021 Oct 21 |
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产品名: 氧化芍药苷(10mM in DMSO,无菌) 去供应商网站查看 询盘CAS: IO01201
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提供多种规格现货供应
产品名: 氧化芍药苷(10mM in DMSO,无菌) 去供应商网站查看 询盘CAS: IO01201
产地: 北京
包装: 1ml/瓶
规格: IO01201-1ml
价格: 电话、微信、QQ、邮件
库存: 现询
电话: 010-50973130
手机: 17801761073(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 17801761073
产品描述: 索莱宝直销,欢迎来询
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