氯哌斯汀芬地柞酸盐

中文名	氯哌斯汀芬地柞酸盐
英文名	o-[(2'-hydroxy[1,1'-biphenyl]-4-yl)carbonyl]benzoic acid, compound with 1-[2-(4-chlorobenzhydryloxy)ethyl]piperidine (1:1)
别名	氯哌酮芬地唑氯哌斯汀芬地柞酸氯哌斯汀芬地柞酸盐氯苄哌醚联苯酰苯酸盐化合物 T13619 1-(2-((4-氯苯基)(苯基)甲氧基)乙基)哌啶 2-(6-羟基-[1,1'-联苯]-3-羰基)苯甲酸盐
英文别名	Cloperastine Febdizoate Cloperastine fendizoate Levocloperastine Fendizoate Levocloperastine Fendizoate Racemic Impurity 1-[2-[(4-Chlorophenyl)phenylmethoxy]ethyl]piperidine Fendizoate 1-[2-[(4-chlorophenyl)-phenylmethoxy]ethyl]piperidine,2-(4-hydroxy-3-phenylbenzoyl)benzoic acid
CAS	85187-37-7
EINECS	286-126-9
化学式	C40H38ClNO5
分子量	648.18642
InChI	InChI=1/C20H24ClNO.C20H14O4/c21-19-11-9-18(10-12-19)20(17-7-3-1-4-8-17)23-16-15-22-13-5-2-6-14-22;21-18-11-10-14(12-17(18)13-6-2-1-3-7-13)19(22)15-8-4-5-9-16(15)20(23)24/h1,3-4,7-12,20H,2,5-6,13-16H2;1-12,21H,(H,23,24)
熔点	185-187°C
沸点	593.9°C at 760 mmHg
闪点	327°C
蒸汽压	5.95E-15mmHg at 25°C
溶解度	DMSO (微溶) 、甲醇 (微溶)
存储条件	Hygroscopic, -20°C Freezer, Under inert atmosphere
稳定性	吸湿性
外观	固体
颜色	White to Off-White
体外研究	Cloperastine inhibits the hERG K + currents in a concentrationdependent manner with IC 50 value of 27±3 nM. Among the antitussive agents, Cloperastine, which possesses antitussive and antiedemic activity, also relaxes the bronchial musculature. Cloperastine is a drug with a central antitussive effect, and is also endowed with an antihistaminic and papaverine-like activity similar to codeine but without its narcotic effects.
体内研究	In the anesthetized guinea pigs, Cloperastine at a therapeutic dose of 1 mg/kg prolonged the QT interval and monophasic action potential (MAP) duration without affecting PR interval or QRS width. Cloperastine hydrochloride shows relatively low acute toxicity when administered by the intraperitoneal route in rats and mice, and shows minor toxicity by the oral route when administered as Cloperastine fendizoate, the LD 50 in rats and mice for the two administration routes exceeds 1000 and 2000 mg/kg, respectively.

氯哌斯汀芬地柞酸盐 - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	1.543 ml	7.714 ml	15.428 ml
5 mM	0.309 ml	1.543 ml	3.086 ml
10 mM	0.154 ml	0.771 ml	1.543 ml
5 mM	0.031 ml	0.154 ml	0.309 ml

最后更新：2024-01-02 23:10:35

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产品名: 1-(2-((4-氯苯基)(苯基)甲氧基)乙基)哌啶 2-(6-羟基-[1,1'-联苯]-3-羰基)苯甲酸盐去供应商网站查看询盘
CAS: 85187-37-7
产地: 北京
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产品名: 氯苄哌醚联苯酰苯酸盐去供应商网站查看询盘
CAS: 85187-37-7
产地: 中国上海
包装: 500mg
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产品描述: 中文名：氯苄哌醚联苯酰苯酸盐英文名:Cloperastine fendizoate CAS:85187-37-7 规格:99% 产地:中国上海

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产品名: Cloperastine fendizoate 去供应商网站查看询盘
CAS: 85187-37-7
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产品名: Cloperastine fendizoate 去供应商网站查看询盘
CAS: 85187-37-7
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规格: 99%
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