水仙环素
水仙环素(Narciclasine)
CAS: 29477-83-6
化学式: C14H13NO7
| 中文名 | 水仙环素 |
| 英文名 | Narciclasine |
| 别名 | 水仙环素 水仙环素对照品 水仙环素标准品 |
| 英文别名 | Narciclasin Narciclasine Lycorcidinol narciclasine (13β)-1,19-Didehydro-2α,3β,4β,7-tetrahydroxy-11,12-dinor-5,19-secocrinan-6-one (2S)-3,4,4aβ,5-Tetrahydro-2α,3β,4β,7-tetrahydroxy[1,3]dioxolo[4,5-j]phenanthridin-6(2H)-one (2S,3R,4S,4aR)-3,4,4a,5-Tetrahydro-2,3,4,7-tetrahydroxy-(1,3)dioxolo(4,5-j)phenanthridin-6(2H)-one (2S-(2-alpha,3-beta,4-beta,4a-beta))-3,4,4a,5-tetrahydro-2,3,4,7-tetrahydroxy-(1,3)Dioxolo(4,5-j)phenanthridin-6(2H)-one |
| CAS | 29477-83-6 |
| 化学式 | C14H13NO7 |
| 分子量 | 307.26 |
| 密度 | 1.85±0.1 g/cm3 (20 ºC 760 Torr) |
| 熔点 | 250-252℃ |
| 沸点 | 447.77°C (rough estimate) |
| 比旋光度 | +145 (c, 1.5 in EtOH) |
| 溶解度 | DMSO: ≥ 10 mg/mL |
| 折射率 | 1.5300 (estimate) |
| 酸度系数 | 7.72±0.70(Predicted) |
| 存储条件 | Store at -20°C |
| 外观 | 固体 |
| 颜色 | white to off-white |
| 物化性质 | 白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于水仙。 |
| MDL号 | MFCD01729949 |
| 体外研究 | Narciclasine activates Rho and stress fibers in glioblastoma multiforme cells. The mean IC 50 of ~50 nM calculated on the 6 human glioblastoma multiforme (U373, Hs683, GL19, GL5, GL16, GL17), The mean IC 50 value of 47 nM for Narciclasine across a panel of 60 cancer cell lines. Bioassay-guided fractionation of the A. belladonna extract resulted in the identification of lycorine as the bio-active compound. The IC 50 measured for radicle growth inhibition is 0.1 µM for Narciclasine. |
| 体内研究 | The i.v. regimen of Narciclasine at 1 mg/kg significantly (P=0.02) increases the survival of GL19 glioblastoma multiforme-bearing mice. Narciclasine when given orally at the same dose five times a week for 5 consecutive weeks also significantly increases animal survival in this model (P=0.008). Oral treatment with Narciclasine at 1 mg/kg significantly increases the survival (P=0.004) of Hs683 glioblastoma multiforme-bearing mice. Increasing the number of doses administered per week does not increase the survival of these Hs683 glioblastoma multiforme-bearing mice. Narciclasine appears to show similar increased survival in these models to temozolomide but at appreciable lower doses and following both oral and i.v. administration. |
| 危险品标志 | Xn - 有害物品 |
| 风险术语 | 46 - 可能引起遗传性基因损害。 |
| 安全术语 | 36 - 穿戴适当的防护服。 |
| 参考资料 展开查看 | 1. [IF=5.491] Jiayu Zhou et al."Fungal endophytes promote the accumulation of Amaryllidaceae alkaloids in Lycoris radiata."Environ Microbiol. 2020 Apr;22(4):1421-1434 |
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