中文名 | 荧光专用试剂 |
英文名 | mBBr [Monobromobimane] |
别名 | 溴二胺 溴代双满 单溴代双满 荧光专用试剂 单溴二胺 MBBR MBBR[单溴二胺] 化合物 T18929 溴代双满,溴二胺,MONOBROMOBIMANE(MBBR ) |
英文别名 | MMB MBBR Bromobimane THIOLYTE(R) MB MONOBROMOBIMANE THIOLYTE(R) MB REAGENT mBBr [Monobromobimane] THIOLYTE MONOBROMOBIMANE REAGENT THIOLYTE(R) MONOBROMOBIMANE REAGENT THIOLYTE(R) MONOBROMOBIMANE REAGENT, FLUORESCENT LABELING COMPOUND |
CAS | 71418-44-5 |
化学式 | C10H11BrN2O2 |
分子量 | 271.11 |
密度 | 1.66±0.1 g/cm3(Predicted) |
熔点 | 152-154°C(lit.) |
沸点 | 327.8±44.0 °C(Predicted) |
溶解度 | DMF: 可溶性 |
酸度系数 | -3.36±0.70(Predicted) |
存储条件 | 2-8°C |
稳定性 | 光敏 |
外观 | 粉末 |
颜色 | Yellow |
最大波长(λmax) | 398 nm |
BRN | 4430959 |
MDL号 | MFCD00036951 |
体外研究 | Bromobimanes in solution (aqueous or organic solvents of medium polarity) react with small thiols [e.g., the tripeptide thiol glutathione (GSH)], and with reactive protein thiol groups (e.g., hemoglobin). The reactions of bromobimanes with thiols are second order and dependent on pH, the active nucleophile being the thiolate anion. The reaction of bromobimane with a thiolate converts the nonfluorescent agent into water-soluble fluorescent products. The neutral agents mBBr and bBBr are moderately soluble in mediumpolarity organic solvents (acetonitrile, dichloromethane), and slightly soluble in water. The quaternary salt, qBBr, and the anionic bromobimane, SBBr, are soluble in water, but less soluble in organic solvents. Bromobimanes are yellow. The highly selective, rapid reactivity of bromobimanes toward thiols, the stability and fluorescence yield of the thiol derivatives, the ease of separation of the derivatives by reversed-phase HPLC, and the availability of both cell-penetrating and nonpenetrating forms, make the use bromobimanes an extremely powerful approach to the analysis of low molecular weight biothiols. |
安全术语 | S22 - 切勿吸入粉尘。 S24/25 - 避免与皮肤和眼睛接触。 |
WGK Germany | 3 |
FLUKA BRAND F CODES | 8 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 3.689 ml | 18.443 ml | 36.885 ml |
5 mM | 0.738 ml | 3.689 ml | 7.377 ml |
10 mM | 0.369 ml | 1.844 ml | 3.689 ml |
5 mM | 0.074 ml | 0.369 ml | 0.738 ml |
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