中文名 | 澳洲茄边碱 |
英文名 | spirosol-5-en-3-yl 6-deoxyhexopyranosyl-(1->2)-[6-deoxyhexopyranosyl-(1->4)]hexopyranoside |
别名 | 边缘茄碱 澳洲茄边碱 澳州茄边碱 Α-奥洲边茄碱 (-)-澳洲茄边碱 澳洲茄边碱(标准品) 澳洲茄边碱(奥洲边茄碱) |
英文别名 | SOLAMERGINE Solamargine solamargine Α-SOLAMARGINE δ-Solanigrine Solamargine 20311-51-7 [(22R,25R)-Spirosola-5-ene-3β-yl]2-O,4-O-bis(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside (3β,22α,25R)-Spirosol-5-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1→2)-[6-deoxy-α-L-mannopyranosyl-(1→4)]-β-D-glucopyranoside |
CAS | 20311-51-7 3671-38-3 30375-08-7 |
化学式 | C45H73NO15 |
分子量 | 868.06 |
InChI | InChI=1/C45H73NO15/c1-19-9-14-45(46-17-19)20(2)30-28(61-45)16-27-25-8-7-23-15-24(10-12-43(23,5)26(25)11-13-44(27,30)6)57-42-39(60-41-36(53)34(51)32(49)22(4)56-41)37(54)38(29(18-47)58-42)59-40-35(52)33(50)31(48)21(3)55-40/h7,19-22,24-42,46-54H,8-18H2,1-6H3/t19-,20+,21+,22+,24+,25-,26+,27+,28+,29-,30+,31+,32+,33-,34-,35-,36-,37+,38-,39-,40+,41+,42-,43+,44+,45-/m1/s1 |
密度 | 1.38 |
熔点 | 301 °C |
比旋光度 | (MeOH)-105;(Py)-102 |
溶解度 | DMSO (微溶) 、甲醇 (微溶) |
折射率 | 1.618 |
酸度系数 | 12?+-.0.70(Predicted) |
存储条件 | Refrigerator |
外观 | 固体 |
颜色 | Light Beige |
物化性质 | 白色结晶粉末,可溶于甲醇、乙醇、DMSO等有机溶剂,来源于澳洲茄 Solanum aviculare Forst.果实。 |
MDL号 | MFCD30207844 |
体外研究 | Solamargine (15 μg/ml; 72 hours) predominantly stimulates the cells of the G2/M phase to apoptosis. Solamargine (72 hours) dramatically inhibits the proliferation of SMMC-7721 and HepG2 cells in a dose- and time-dependent manner. The IC 50 s are 9.21 and 19.88 μg/ml, respectively. Cell Viability Assay Cell Line: SMMC-7721cells Concentration: 15 μg/ml Incubation Time: 72 hours Result: Displayed a significant increase of sub-G1. |
体内研究 | Solamargine (10 mg/kg; intragastric administration; once daily for 8 days) exhibits an antitumor effect and promotes the apoptosis of GC in vivo. Animal Model: Female specific pathogen-free BALB/c nude mice weighing 18-20 g (6-8-weeks-old) Dosage: 10 mg/kg Administration: Intragastric administration; once daily for 8 days Result: Tumor growth was significantly inhibited . |
参考资料 展开查看 | 1. 李俊,熊峰.澳洲茄边碱通过Caspase3蛋白诱导人肺腺癌A549细胞的凋亡作用[J].氨基酸和生物资源,2016,38(03):21-24. 2. [IF=2.289] Zhou Shun et al."Anthelmintic efficacy of natural saponins against Gyrodactylus kobayashii in goldfish (Carassius auratus) and their 3D-QSAR analysis."Parasitol Res. 2021 Mar;120(3):1143-1150 |
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