牛蒡苷元
牛蒡子苷元(Arctigenin)
CAS: 7770-78-7
化学式: C21H24O6
| 中文名 | 牛蒡子苷元 |
| 英文名 | Arctigenin |
| 别名 | 牛蒡苷元 牛蒡甙元 牛蒡子元 牛蒡子苷元 牛蒡苷元(标准品) 牛蒡子苷元对照品, (-)-牛蒡苷元, 来源于牛蒡子 |
| 英文别名 | Arctigenin ARCTIGENIN (-)-ARCTIGENIN (-)-Arctigenin 2(3H)-Furanone,4-[(3,4-dimethoxyphenyl) methyl] dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-,(3R,4R)- 4-(3,4-dimethoxybenzyl)-3-(4-hydroxy-3-methoxybenzyl)dihydrofuran-2(3H)-one (3R,4R)-4-(3,4-dimethoxybenzyl)-3-(4-hydroxy-3-methoxybenzyl)dihydrofuran-2(3H)-one 2(3H)-FURANONE,4-[(3,4-DIMETHOXYPHENYL)METHYL]DIHYDRO-3-[(4-HYDROXY-3-METHOXYPHENYL)METHYL] (3R,4R)-4-[(3,4-DIMETHOXYPHENYL)METHYL]DIHYDRO-3-[(4-HYDROXY-3-METHOXYPHENYL)METHYL]-2(3H)-FURANONE 2(3H)-FURANONE,4-[(3,4-DIMETHOXYPHENYL)METHYL]DIHYDRO-3-[(4-HYDROXY-3-METHOXYPHENYL)METHYL]-,(3R,4R) 2(3H)-Furanone, 4-((3,4-dimethoxyphenyl)methyl)dihydro-3-((4-hydroxy-3-methoxyphenyl)methyl)-, (3R,4R)- 2(3H)-Furanone, 4-((3,4-dimethoxyphenyl)methyl)dihydro-3-((4-hydroxy-3-methoxyphenyl)methyl)-, (3R-trans)- |
| CAS | 7770-78-7 |
| 化学式 | C21H24O6 |
| 分子量 | 372.41 |
| InChI | InChI=1/C21H24O6/c1-24-18-7-5-13(11-20(18)26-3)8-15-12-27-21(23)16(15)9-14-4-6-17(22)19(10-14)25-2/h4-7,10-11,15-16,22H,8-9,12H2,1-3H3 |
| InChIKey | NQWVSMVXKMHKTF-JKSUJKDBSA-N |
| 密度 | 1.227±0.06 g/cm3(Predicted) |
| 熔点 | 98.0 to 102.0 °C |
| 沸点 | 567.0±45.0 °C(Predicted) |
| 比旋光度 | -28.7°（c=1.2，chloroform） |
| 闪点 | 198.8°C |
| 蒸汽压 | 1.85E-13mmHg at 25°C |
| 溶解度 | DMSO: 34mg/ml，加热和超声处理，可溶 |
| 折射率 | 1.576 |
| 酸度系数 | 10.03±0.20(Predicted) |
| 存储条件 | Sealed in dry,Store in freezer, under -20°C |
| 外观 | 固体 |
| 颜色 | White to Light yellow |
| 最大波长(λmax) | ['280nm(EtOH)(lit.)'] |
| 物化性质 | 白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于牛蒡子，络石藤，了哥王，水母雪莲、连翘。 |
| MDL号 | MFCD00870597 |
| 安全术语 | S22 - 切勿吸入粉尘。 S24/25 - 避免与皮肤和眼睛接触。 |
| WGK Germany | 3 |
| RTECS | LY9247000 |
| 参考资料 展开查看 | 1. 许佳欣,佘家军,杨锐,向雨晨,司渊,刘莹.天然药物牛蒡苷元直接靶向STAT3抑制三阴性乳腺癌的分子对接及分子动力学研究[J].湖北医药学院学报,2019,38(01):1-9. 2. 狄恒建, 李松, 郭青,等. 炒牛蒡子配方颗粒HPLC指纹图谱研究[J]. 药学与临床研究, 2013, 021(006):637-639. 3. 陆明, 姬飞虹, 张林杰. 牛蒡子苷元对小鼠脾细胞增殖的影响及相关机制[J]. 安徽医科大学学报, 2014(6):726-730. 4. 袁晓宁, 马文静, 孙智婷,等. 牛蒡苷元下调CIP2A抑制三阴性乳腺癌转移的作用及机制研究[J]. 湖北医药学院学报, 2017(05):391-396. 5. Yuru Du, Wenjing Li, Yiming Li, Juxiang Yang, Xinhao Wang, Shuo Yin, Xi Wang, Omar Israel Velez de-la-Paz, Yuan Gao, Haiying Chen, Xi Yin, Haishui Shi, Repeated arctigenin treatment produces antidepressant- and anxiolytic-like effects in mice, Brain Resear 6. Huang, Qiuyue, et al. "Arctigenin inhibits triple-negative breast cancers by targeting CIP2A to reactivate protein phosphatase 2A." Oncology reports 38.1 (2017): 598-606.https://doi.org/10.3892/or.2017.5667 7. Feng, Tingting, et al. "Arctigenin inhibits STAT3 and exhibits anticancer potential in human triple-negative breast cancer therapy." Oncotarget 8.1 (2017): 329.https://dx.doi.org/10.18632%2Foncotarget.13393 8. Lu, Yu-Nan, et al. "Arctigenin exhibits hepatoprotective activity in Toxoplasma gondii-infected host through HMGB1/TLR4/NF-κB pathway." International immunopharmacology 84 (2020): 106539.https://doi.org/10.1016/j.intimp.2020.106539 9. Cheng, Jia-Hui, et al. "Arctigenin ameliorates depression-like behaviors in Toxoplasma gondii-infected intermediate hosts via the TLR4/NF-κB and TNFR1/NF-κB signaling pathways." International immunopharmacology 82 (2020): 106302.https://doi.org/10.1016/j.i 10. Valkó, Klára. "Application of high-performance liquid chromatography based measurements of lipophilicity to model biological distribution." Journal of chromatography A 1037.1-2 (2004): 299-310.https://doi.org/10.1016/j.chroma.2003.10.084 11. Valkó, Klára. "Application of high-performance liquid chromatography based measurements of lipophilicity to model biological distribution." Journal of chromatography A 1037.1-2 (2004): 299-310.https://doi.org/10.1016/j.chroma.2003.10.084 12. [IF=5.64] Wu Dousheng et al."Oleanolic Acid Induces the Type III Secretion System of Ralstonia solanacearum."Front Microbiol. 2015 Dec;0:1466 13. [IF=4.411] Jifeng Gu et al."Application of High-Performance Liquid Chromatography Coupled with Linear Ion Trap Quadrupole Orbitrap Mass Spectrometry for Qualitative and Quantitative Assessment of Shejin-Liyan Granule Supplements."Molecules. 2018 Apr;23(4):884 14. [IF=4.077] Yuru Du et al."Repeated arctigenin treatment produces antidepressant- and anxiolytic-like effects in mice."Brain Res Bull. 2019 Mar;146:79 15. [IF=3.417] Qiuyue Huang et al."Arctigenin inhibits triple-negative breast cancers by targeting CIP2A to reactivate protein phosphatase 2A."Oncol Rep. 2017 Jul;38(1):598-606 16. [IF=0] Tingting Feng et al."Arctigenin inhibits STAT3 and exhibits anticancer potential in human triple-negative breast cancer therapy."Oncotarget. 2017 Jan 3; 8(1): 329–344 17. [IF=3.943] Jia-Hui Cheng et al."Arctigenin ameliorates depression-like behaviors in Toxoplasma gondii-infected intermediate hosts via the TLR4/NF-κB and TNFR1/NF-κB signaling pathways."Int Immunopharmacol. 2020 May;82:106302 18. [IF=3.943] Yu-Nan Lu et al."Arctigenin exhibits hepatoprotective activity in Toxoplasma gondii-infected host through HMGB1/TLR4/NF-κB pathway."Int Immunopharmacol. 2020 Jul;84:106539 19. [IF=3] Qu Lala et al."Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay."N-S Arch Pharmacol. 2020 Jun;393(6):937-950 20. [IF=2.447] Wenfang Luo et al."Arctigenin inhibits human breast cancer cell proliferation, migratory and invasive abilities and epithelial to mesenchymal transition by targeting 4EBP1."Exp Ther Med. 2021 Jun;21(6):1-7 21. [IF=5.81] Zhu DW et al."Exploring the Anti-Pulmonary Fibrosis Mechanism of Jingyin Granule by Network Pharmacology Strategy.."Front Pharmacol. 2022 Feb;13:825667-825667 |
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产品名: 牛蒡子苷元,牛蒡苷元 询盘CAS: 7770-78-7
产地: 湖北武汉
包装: 1kg,25kg,200kg
价格: 电联、邮件
库存: 现货
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产品名: 牛蒡子苷元,牛蒡苷元 询盘CAS: 7770-78-7
产地: 上海
包装: 1kg, 25kg, 200kg
价格: 电联
库存: 现货
电话: 18721521379
手机: 18721521379
电子邮件: 18721521379@163.com
微信: 18721521379
产品描述: 巴师傅化工原料厂家直供、产品丰富多样、批量采购价格更优！店铺展示的商品仅为我司部分精选,了解更多产品详情欢迎致电：刁经理18721521379,期待与您的沟通！
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产品名: 牛蒡苷元(10mM in DMSO,无菌) 去供应商网站查看 询盘CAS: IA04501
产地: 北京
包装: 1ml/瓶
规格: IA04501-1ml
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库存: 现询
电话: 010-50973130
手机: 17801761073(微信同号)
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微信: 17801761073
产品描述: 索莱宝直销,欢迎来询
现货供应
产品名: 牛蒡子苷元,牛蒡苷元 询盘CAS: 7770-78-7
产地: 江苏南通
包装: 1kg, 25kg, 200kg
价格: 电联、邮件
库存: 现货
电话: 0513-66814855
手机: 13776910623
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