玫瑰树盐酸盐_化工百科

中文名	Ellipticine (hydrochloride)
英文名	Ellipticine (hydrochloride)
别名	玫瑰树盐酸盐玫瑰树碱盐酸盐 ELLIPTICINE 盐酸盐 5,11-二甲基-6H-吡啶并[4,3-B]咔唑盐酸盐 ELLIPTICINE HYDROCHLORIDE盐酸盐
英文别名	NSC 71795 (hydrochloride) Ellipticine (hydrochloride) Ellipticine hydrochloride(NSC 71795 hydrochloride)
CAS	5081-48-1
化学式	C17H15ClN2
分子量	282.77
溶解度	DMSO: 5.8 mg/mL
存储条件	Inert atmosphere,Store in freezer, under -20°C
体外研究	Ellipticine (NSC 71795) is a potent antineoplastic agent exhibiting the multimodal mechanism of its action. The mechanisms of Ellipticine (NSC 71795) antitumor, mutagenic and cytotoxic activities are suggested to be intercalation into DNA and inhibition of DNA topoisomerase II activity. Another mode of Ellipticine (NSC 71795) action is the formation of covalent DNA adducts mediated by its oxidation with cytochromes P450 (CYP) and peroxidases. Ellipticine (NSC 71795) can also act as an inhibitor or inducer of biotransformation enzymes, thereby modulating its own metabolism leading to its genotoxic and pharmacological effects. Treatment of cells with Ellipticine (NSC 71795) results in inhibition of cell growth and proliferation. This effect is associated with formation of two covalent Ellipticine (NSC 71795)-derived DNA adducts.
体内研究	Ellipticine (NSC 71795) treatment results in ellipticine-derived DNA adduct generation in several healthy organs (liver, kidney, lung, spleen, breast, heart and brain) and in DNA of mammary adenocarcinoma. The levels of Ellipticine (NSC 71795)-derived DNA adducts generated in these adenocarcinomas are almost 2-fold higher than in normal healthy mammary tissue. The induced expression of cytochrome b 5 protein in liver of rats treated with Ellipticine (NSC 71795) suggests that cytochrome b 5 may modulate the CYP-mediated bioactivation and detoxification of Ellipticine (NSC 71795).

玫瑰树盐酸盐 - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	3.536 ml	17.682 ml	35.365 ml
5 mM	0.707 ml	3.536 ml	7.073 ml
10 mM	0.354 ml	1.768 ml	3.536 ml
5 mM	0.071 ml	0.354 ml	0.707 ml

最后更新：2024-01-02 23:10:35

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产品名: 5,11-二甲基-6H-吡啶并[4,3-b]咔唑盐酸盐去供应商网站查看询盘
CAS: 5081-48-1
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上海麦克林生化科技股份有限公司

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