甲磺酸罗哌卡因854056-07-8
甲磺酸罗哌卡因(Ropivacaine mesylate)
CAS: 854056-07-8
化学式: C18H30N2O4S
| 中文名 | 甲磺酸罗哌卡因 |
| 英文名 | Ropivacaine mesylate |
| 别名 | 甲磺酸罗哌卡因 罗哌卡因甲磺酸盐 甲磺酸罗哌卡因中间体 S-罗哌卡因甲磺酸盐 甲磺酸罗哌卡因854056-07-8 N-(2,6-二甲基苯基)-1-丙基哌啶-2-甲酰胺甲磺酸盐 N-(2,6-二甲基苯基)-1-正丙基哌啶-2-甲酰胺甲磺酸盐 (S)-N-(2,6-二甲基苯基)-1-丙基-2-哌啶酰胺甲磺酸盐 S-(-)-N-(2,6-二甲基苯基)-1-丙基-2-哌啶甲酰胺甲磺酸盐 |
| 英文别名 | ROPIVACAINE MESYLATE Ropivacaine mesylate S-Ropivacaine mesylate (S)-Ropivacaine Mesilate Ropivacaine Mesylate API Ropivacaine Mesylate Injection TIANFUCHEM--854056-07-8--Ropivacaine mesylate in stock (S)-N-(2,6-Dimethylphenyl)-1-propylpiperidine-2-carboxamidemethanesulfonate (2S)-N-(2,6-Dimethylphenyl)-1-propyl-2-piperidinecarboxamide monomethanesulfonate Ropivacaine mesylate (2S)-N-(2,6-Dimethylphenyl)-1-propyl-2-piperidinecarboxamide monomethanesulfonate |
| CAS | 854056-07-8 |
| EINECS | 264-407-7 |
| 化学式 | C18H30N2O4S |
| 分子量 | 370.51 |
| InChI | InChI=1/C17H26N2O.CH4O3S/c1-4-11-19-12-6-5-10-15(19)17(20)18-16-13(2)8-7-9-14(16)3;1-5(2,3)4/h7-9,15H,4-6,10-12H2,1-3H3,(H,18,20);1H3,(H,2,3,4)/t15-;/m0./s1 |
| 体内研究 | Epidural administration of Ropivacaine mesylate effectively blocks neuropathic pain (both mechanical allodynia and heat hyperalgesia) without induction of analgesic tolerance and significantly delays the development of neuropathic pain produced by peripheral nerve injury. Ropivacaine mesylate inhibits pressure-induced increases in filtration coefficient (Kf) without affecting pulmonary artery pressure (Ppa), pulmonary capillary pressures (Ppc), and zonal characteristics (ZC). Ropivacaine mesylate prevents pressure-induced lung edema and associated hyperpermeability as evidence by maintaining PaO2, lung wet-to-dry ratio and plasma volume in levels similar to sham rats. Ropivacaine mesylate inhibits pressure-induced NO production as evidenced by decreased lung nitro-tyrosine content when compared to hypertensive lungs. Animal Model: Adult Sprague-Dawley rats (300-400g) Dosage: 1 μM Administration: Infusion (added to the perfusate reservoir) Result: Attenuated pressure-dependent increases in filtration coefficient (K f ). |
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