中文名 | 盐酸贝那替嗪 |
英文名 | benactyzine hydrochloride |
别名 | 胃乐康 贝那替秦 乙胺痉平 盐酸苯那辛 盐酸苯乃嗪 盐酸贝那替嗪 盐酸贝那替秦 苯羟乙胺盐酸盐 2-(二乙氨基)乙基二苯乙醇酸酯 盐酸盐 2-二乙基氨基乙基 2-羟基-2,2-二苯乙酸酯盐酸盐 |
英文别名 | Amizyl Benactyzine HCL BENACTYCIN HYDROCHLORIDE benactyzine hydrochloride 2-(diethylamino)-ethanobenzilatehydrochloride 2-Diethylaminoethyl Diphenylglycolate Hydrochloride 2-(difenyl-hydroxyacetoxy)ethyl-diethylammoniumchlorid 2-(Difenyl-hydroxyacetoxy)ethyl-diethylammoniumchlorid [czech] 2-(Diethylamino)ethyl benzilate hydrochloride, Benactyzine, α-Hydroxy-α-phenylbenzeneacetic acid 2-(diethylamino)ethyl ester |
CAS | 57-37-4 |
EINECS | 200-324-4 |
化学式 | C20H26ClNO3 |
分子量 | 363.88 |
InChI | InChI=1/C20H25NO3.ClH/c1-3-21(4-2)15-16-24-19(22)20(23,17-11-7-5-8-12-17)18-13-9-6-10-14-18;/h5-14,23H,3-4,15-16H2,1-2H3;1H |
熔点 | 177-179°C(lit.) |
沸点 | 409.3°C at 760 mmHg |
闪点 | 201.4°C |
蒸汽压 | 1.96E-07mmHg at 25°C |
溶解度 | DMSO (微溶,加热),甲醇 (微溶) |
存储条件 | Keep in dark place,Sealed in dry,Room Temperature |
外观 | 固体 |
颜色 | Crystals from Me2CO |
Merck | 14,1029 |
物化性质 | 白色或几乎白色结晶性粉末。熔点177-181℃。25℃时100ml水中可溶解该品14.9g,几乎不溶于乙醚。无臭,味微苦。其碱基([302-40-9])熔点51℃。 |
体外研究 | Benactyzine hydrochloride and drofenine are widely used anticholinergic drugs which are also competitive inhibitors of BChE with K i values of 0.010±0.001 and 0.003±0.000 mM, respectively. Results indicate that the inhibition of BChE by Benactyzine hydrochloride is pure or partial competitive. Pure competitive inhibition can be distinguished from partial competitive inhibition by plotting v vs [Benactyzine] at a fixed [BTCh]. |
体内研究 | Benactyzine hydrochloride (1 mg/kg) does not influence the attention response. Benactyzine hydrochloride increases the duration of the exploratory-motor reaction, but slightly diminishes the salivation elicited by acetylcholine. There is no blocking effect of Benactyzine hydrochloride and promazine on the EEG-seizure activity elicited by acetylcholine, and almost no inhibitory effect on emotional reactions. Emotional reactions are blocked by high doses of imipramine and promazine, but not by Benactyzine hydrochloride. The data indicates that imipramine, promazine and Benactyzine hydrochloride influence the autonomic effects of serotonin in different ways. Promazine, and especially Benactyzine hydrochloride, inhibit and shorten the period of salivation elicited by the intra-amygdaloid injection of serotonin. |
危险品标志 | T - 有毒物品 |
风险术语 | 23/24/25 - 吸入、皮肤接触及吞食有毒。 |
安全术语 | S36/37/39 - 穿戴适当的防护服、手套和护目镜或面具。 S45 - 若发生事故或感不适,立即就医(可能的话,出示其标签)。 |
危险品运输编号 | UN 2811 6.1/PG 3 |
WGK Germany | 3 |
RTECS | DD2800000 |
Hazard Class | 6.1(b) |
Packing Group | III |
上游原料 | 二苯基乙醇酸 盐酸 1,1-二苯基-1-羟基乙酸乙酯 |
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