中文名 | 盐酸番茄碱 |
英文名 | Tomatidine hydrochloride |
别名 | 盐酸番茄碱 水解番茄碱 盐酸西红柿碱 番茄碱盐酸盐 水解番茄硷盐酸盐 盐酸番茄碱对照品 盐酸番茄碱标准品 |
英文别名 | TOMATIDINE HCL TOMATIDINE HCL(RG) TOMATIDINE HYDROCHLORIDE Tomatidine hydrochloride SPIRPSOLAN-3-OL-(3B,5A,22B,25C) HCL 5ALPHA-TOMATIDAN-3BETA-OL HYDROCHLORIDE 3BETA-HYDROXY-5ALPHA-TOMATIDANE HYDROCHLORIDE (3beta,5alpha,22beta,25S)-Spirosolan-3-ol hydrochloride |
CAS | 6192-62-7 |
化学式 | C27H46ClNO2 |
分子量 | 452.11 |
熔点 | 281-284°C (dec.) |
溶解度 | 甲醇 (微溶) |
存储条件 | 2-8°C |
外观 | 灰白色固体 |
颜色 | White to Off-White |
BRN | 3920740 |
体外研究 | Tomatidine decreases inducible NO synthase and COX-2 expression through suppression of I-κBα phosphorylation, NF-κB nuclear translocation and JNK activation, which in turn inhibits c-jun phosphorylation and Oct-2 expression. Tomatidine, solasodine and diosgenin (40 μM) show 66%, 22% and 41% inhibition of nitrite production, respectively. The iNOS protein is barely detectable in unstimulated cells but markedly increases after LPS treatment, and Tomatidine causes dose-dependent inhibition of LPS-induced iNOS expression. p65 is the major component of NF-κB in LPS-stimulated macrophages, the effect of Tomatidine on p65 DNA-binding activity is determined. In the presence of Tomatidine at 10-40 μM, the binding activity of NF-κB is suppressed in a dose-dependent manner. Tomatidine inhibits the phosphorylation of I-κB, blocks the I-κB production, and furthermore suppresses p65 NF-κB translocation to the nucleus and modulated binding activity. |
安全术语 | S22 - 切勿吸入粉尘。 S24/25 - 避免与皮肤和眼睛接触。 |
WGK Germany | 3 |
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