中文名 | 4-(2-(1H-咪唑-1-基)乙氧基)苯甲酸盐酸盐 |
英文名 | 4-(2-(1H-Imidazol-1-yl)ethoxy)benzoic acid hydrochloride |
别名 | 盐酸达唑苄 盐酸达唑氧苯 化合物UK-37248 4-(2-(1H-咪唑-1-基)乙氧基)苯甲酸盐酸盐 |
英文别名 | UK-37248 UK-37248-01 Dazoxiben HCl Dazoxiben hydrochloride 4-(2-(1H-Imidazol-1-yl)ethoxy)benzoic acid hydrochloride |
CAS | 74226-22-5 |
化学式 | C12H13ClN2O3 |
分子量 | 268.69622 |
熔点 | 230-235 °C(Solv: ethanol (64-17-5); ethyl ether (60-29-7)) |
存储条件 | under inert gas (nitrogen or Argon) at 2-8°C |
MDL号 | MFCD00475663 |
体外研究 | Dazoxiben inhibits TXB2 production in clotting human whole blood with an IC 50 of 0.3 μM and causes parallel enhancement of PGE2 greater than PGF2 alpha greater than 6-keto-PGF1 alpha production. Dazoxiben inhibits TXB2 production in rat kidney glomeruli with an IC 50 of 1.60 μM) than in rat whole blood (IC 50 = 0.32μM), and is not associated with changes in PGE2, PGF2 alpha and 6-keto-PGF1 alpha production. |
体内研究 | Dazoxiben (intraperitoneal administration; 100 μg/kg) produces a marked prolongation of the tail bleeding time with 96.8 ± 10.8 secs. |
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