中文名 | 盐酸青藤碱 |
英文名 | Sinomenine hydrochloride |
别名 | 藤根提取物 盐酸防己碱 盐酸青藤碱 藤根提取物-青藤碱 盐酸青藤碱(标准品) 盐酸青藤碱(分析标准品) SINOMENINE HYDROCHLORIDE 盐酸青藤碱 SINOMENINE HYDROCHLORIDE 盐酸青藤碱 标准品 (4BR,8AS,9S)-4-羟基-3,7-二甲氧基-11-甲基-9,10-二氢-5H-9,4B-(EPIMINOETHANO)菲-6-6(8AH)-酮 盐酸盐 |
英文别名 | Sinomenine HCL SINOMENINE HCL Cucoline hydrochloride Sinomenine Hydrocloride Sinomenine hydrochloride SINOMENINE HYDROCHLORIDE (9α,13α,14α)- 7,8-Didehydro-4-hydroxy-3,7-diMet 4-hydroxy-3,7-dimethoxy-17-methyl-7,8-didehydromorphinan-6-one hydroxy-dimethoxy-methyl-BLAH-azatetracyclo[BLAH]hexadeca-BLAH,BLAH,BLAH,BLAH-tetraenone 7,8-Didehydro-4-hydroxy-3,7-diMethoxy-17-Methyl-9α,13α,14α-Morphinan-6-one Hydrochloride (9a,13a,14a)-4-Hydroxy-3,7-dimethoxy-17-methyl-7,8-didehydromorphinan-6-one hydrochloride (9alpha,13alpha,14alpha)-4-hydroxy-3,7-dimethoxy-17-methyl-7,8-didehydromorphinan-17-ium-6-one chloride |
CAS | 6080-33-7 |
化学式 | C19H24ClNO4 |
分子量 | 365.85 |
InChI | InChI=1/C19H23NO4.ClH/c1-20-7-6-19-10-14(21)16(24-3)9-12(19)13(20)8-11-4-5-15(23-2)18(22)17(11)19;/h4-5,9,12-13,22H,6-8,10H2,1-3H3;1H/t12-,13-,19+;/m1./s1 |
熔点 | 231.0 to 235.0 °C |
沸点 | 513.6°C at 760 mmHg |
闪点 | 264.4°C |
蒸汽压 | 3.59E-11mmHg at 25°C |
溶解度 | H2O: 可溶物20mg/mL,澄清 |
存储条件 | Inert atmosphere,2-8°C |
外观 | 粉末 |
颜色 | white to beige |
物化性质 | 白色针状结晶,可溶于甲醇、乙醇、DMSO等有机溶剂。 |
MDL号 | MFCD01714307 |
体外研究 | Cell viability is gradually decreased with increasing Sinomenine hydrochloride concentration. The migration ability of MDA-MB-231 cells is significantly weakened by 0.25, 0.5, and 1 mM of Sinomenine hydrochloride treatment. The wound-healing assay reveals that 0.25 and 0.5 mM Sinomenine hydrochloride significantly suppress the healing of the wound. When the MDA-MB-231 cells are treated with 0.5 mM Sinomenine hydrochloride, the healing progress is about 50%, but in the group treated with 0.25 mM Sinomenine hydrochloride and the untreated control, the healing is about 80% and nearly 95%, respectively. The IB assay following inhibitor of NF-κB (IκB) antibody IP shows that the binding of NF-κB to IκB is inhibited by Sinomenine hydrochloride treatment in a dose-dependent manne. |
体内研究 | Sinomenine hydrochloride (i.p.) produces antinociception in the hot plate and tail flick tests in male rats at 40 mg/kg, but not at lower doses (10 or 20 mg/kg). At 10 to 40 mg/kg Sinomenine hydrochloride does not produce any observable side effect such as sedation, allergy or motor impairments. At 80 mg/kg, Sinomenine hydrochloride is mildly sedative in rats. Sinomenine hydrochloride at 80 mg/kg i.p. does not produce any observable side effects in mice. I.p or p.o. Sinomenine hydrochloride at 40 or 80 mg/kg dose-dependently reduces mechanical hypersensitivity in nerve injured mice. I.p. Sinomenine hydrochloride at 40 mg/kg, but not lower doses or vehicle, significantly decreases mechanical and cold allodynia for up to 240 min without producing motor deficits or sedation. At doses of 10 to 40 mg/kg, Sinomenine hydrochloride dose-dependently increases the paw withdrawal threshold. In non-chronic constriction injury (CCI) healthy rats, Sinomenine hydrochloride at the dose range of 10 to 40 mg/kg does not change the immobility behavior in the forced swimming test. |
安全术语 | 24/25 - 避免与皮肤和眼睛接触。 |
WGK Germany | 3 |
RTECS | QD2163000 |
海关编号 | 29334900 |
参考资料 展开查看 | 1. 谭梅傲,方学君,曹敏,佘世锋,兰绍阳,刘晓曼,梁艺.青藤碱联合骨髓间充质干细胞预防Con A诱导大鼠免疫性肝损伤的实验研究[J].中国中西医结合杂志,2020,40(05):575-581. 2. 朱昱豪, 谭梅傲, 佘世锋,等. 青藤碱通过免疫调节防护刀豆蛋白A诱导的大鼠急性免疫性肝损伤[J]. 广州中医药大学学报, 2018, 035(003):476-481. 3. [IF=4.243] Aomei Zhao et al."Synergic radiosensitization of sinomenine hydrochloride and radioiodine on human papillary thyroid carcinoma cells."Transl Oncol. 2021 Oct;14:101172 |
微信搜索化工百科或扫描下方二维码,添加化工百科小程序,随时随地查信息!