中文名 | 加替沙星 |
英文名 | Gatifloxacin |
别名 | 盖替沙星 格替沙星 加替沙星 加替沙星片 加替沙星(标准品) 加替沙星溶液,100PPM 加替沙星 112811-59-3 1-环丙基-6-氟-1,4-二氢-8-甲氧基-7-(3-甲基-1-哌嗪基)-4-氧代-3-喹啉羧酸 1-环丙基-6-氟-7 -(3-甲基哌嗪-1-基)-8-甲氧基-1,4-二氢-4-氧-喹啉-3-羧酸 |
英文别名 | AM1155 AM 1155 AM-1155 PD135432 Gatiquin PD-135432 PD 135432 GATIFLOXACIN Gatifloxacin BMS206584-01 BMS 206584-01 Gatifloxacin API 1-CYCLOPROPYL-6-FLUORO-1,4-DIHYDRO-8-METHOXY-7-(3-METHYLPIPERAZIN-1-YL)-4-OXO-3-QUINOLINECARBOXYLIC ACID 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid 1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 1-CYCLOPROPYL-6-FLUORO-1,4-DIHYDROXY-8-METHOXY-7-(3-METHYL-1-PIPERAZINYL)-4-OXO-3-QUINOLINECARBOXYLIC ACID |
CAS | 112811-59-3 |
EINECS | 664-293-2 |
化学式 | C19H22FN3O4 |
分子量 | 375.39 |
InChI | InChI=1/C19H22FN3O4/c1-10-8-22(6-5-21-10)16-14(20)7-12-15(18(16)27-2)23(11-3-4-11)9-13(17(12)24)19(25)26/h7,9-11,21H,3-6,8H2,1-2H3,(H,25,26) |
密度 | 1.386±0.06 g/cm3(Predicted) |
熔点 | 162°C |
沸点 | 607.8±55.0 °C(Predicted) |
闪点 | 321.4°C |
蒸汽压 | 1.26E-15mmHg at 25°C |
溶解度 | 氯仿 (微溶,加热),甲醇 (微溶,加热) |
折射率 | 1.616 |
酸度系数 | 6.43±0.50(Predicted) |
存储条件 | Sealed in dry,2-8°C |
外观 | 白色至黄色结晶粉末。 |
颜色 | White to Off-White |
MDL号 | MFCD00895399 |
危险品标志 | Xn - 有害物品 |
风险术语 | 20/21/22 - 吸入、皮肤接触及吞食有害。 |
安全术语 | 36/37 - 穿戴适当的防护服和手套。 |
海关编号 | 29335990 |
参考资料 展开查看 | 1. 石庆新,杨阳,蔡莺莺,周铁丽.耐多药结核分枝杆菌对喹诺酮药物的耐药特性及分子机制的研究[J].浙江医学,2019,41(06):521-524+528. 2. 姜丽杰,柳建,董燕.患儿医院感染病原菌分布及耐药性调查[J].中国病原生物学杂志,2019,14(07):840-843+847. 3. Pan, Ziyu, et al. "High‐performance liquid chromatography study of gatifloxacin and sparfloxacin using erythrosine as post‐column resonance Rayleigh scattering reagent and mechanism study." Luminescence 33.2 (2018): 417-424.https://doi.org/10.1002/bio.3429 4. Xu, Meng, et al. "Chemical composition, antibacterial properties, and mechanism of Smilax china L. polyphenols." Applied microbiology and biotechnology 103.21 (2019): 9013-9022.https://doi.org/10.1007/s00253-019-10100-0 5. [IF=4.821] Ziyu Pan et al."Simultaneous determination of five fluoroquinolones by the selective high performance liquid chromatography associating with sensitive resonance light scattering and mechanism study."Microchem J. 2018 Jan;136:71 6. [IF=2.464] Ziyu Pan et al."High-performance liquid chromatography study of gatifloxacin and sparfloxacin using erythrosine as post-column resonance Rayleigh scattering reagent and mechanism study."Luminescence. 2018 Mar;33(2):417-424 7. [IF=7.514] Bolong Fang et al."Glucose oxidase-induced colorimetric immunoassay for qualitative detection of danofloxacin based on iron (Ⅱ) chelation reaction with phenanthroline."Food Chem. 2020 Oct;328:127099 8. [IF=6.057] Song Hu et al."Reliable performance of aggregation-induced emission nanoparticle-based lateral flow assay for norfloxacin detection in nine types of animal-derived food."Talanta. 2020 Nov;219:121245 9. [IF=4.813] Xu Meng et al."Chemical composition, antibacterial properties, and mechanism of Smilax china L. polyphenols."Appl Microbiol Biot. 2019 Nov;103(21):9013-9022 10. [IF=5.293] Qian Weidong et al."Antifungal and Antibiofilm Efficacy of Paeonol Treatment Against Biofilms Comprising Candida albicans and/or Cryptococcus neoformans."Frontiers in Cellular and Infection Microbiology. 2022 May;0:588 |
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