中文名 | 硝酸异康唑 |
英文名 | isoconazole nitrate |
别名 | 硝酸异康唑 氯氨酮杂质A 硝酸邻氯益康唑 咪康唑EP杂质D 硝酸异康唑(标准品) 硝酸异康唑 EP标准品 1-[2-(2,4-二氯苯基)-2-[(2,6-二氯苯基)甲氧基]乙基]-1H-咪唑单硝酸盐 |
英文别名 | Fazol R 15454 24168-96-5 Adestan G 100 Gyno-Travogen isoconazole nitrate Imidazole, 1-[2,4-dichloro-b-[(2,6-dichlorobenzyl)oxy]phenethyl]-, mononitrate (8CI) 1-{2-[(2,6-Dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazol-1-ium nitrate 1-[2-(2,4-dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]-1H-imidazolium nitrate 1-[2-(2,4-dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]-1h-imidazole mononitrate 1-[2-(2,4-dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]-3H-imidazol-1-ium nitrate 1H-Imidazole, 1-[2-(2,4-dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]-, mononitrate (9CI) |
CAS | 24168-96-5 |
EINECS | 246-051-4 |
化学式 | C18H15Cl4N3O4 |
分子量 | 479.14 |
InChI | InChI=1/C18H14Cl4N2O.NO3/c19-12-4-5-13(17(22)8-12)18(9-24-7-6-23-11-24)25-10-14-15(20)2-1-3-16(14)21;2-1(3)4/h1-8,11,18H,9-10H2;/q;-1/p+1 |
熔点 | 178-182°C |
沸点 | 178-182℃ |
溶解度 | 极微溶于水,溶于甲醇,微溶于乙醇 (96%)。 |
存储条件 | Sealed in dry,2-8°C |
外观 | 整洁 |
颜色 | White to Off-White |
Merck | 14,5160 |
体外研究 | Isoconazole nitrate also exerts several other effects on the fungal membrane, which are independent of inhibition of the ergosterol synthesis. Isoconazole nitrate (ISN) causes a rapid reduction of cellular adenosine triphosphate (ATP) within 10 min of in vitro exposure. Isoconazole nitrate (1, 10 μg/mL) induces a blockade of cell division in vitro by its action on synthesis and organisation of the cell membrane. Isoconazole nitrate (50, 100 μg/mL), ISN induced necrosis and death of fungal cells. |
RTECS | NI4772000 |
上游原料 | 氢化钠 |
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