硫黄素T
硫黄素T(2-[4-(dimethylamino)phenyl]-3,6-dimethylbenzothiazolium chloride)
CAS: 2390-54-7
化学式: C17H19ClN2S
| 中文名 | 硫黄素T |
| 英文名 | 2-[4-(dimethylamino)phenyl]-3,6-dimethylbenzothiazolium chloride |
| 别名 | 盐基嫩黄 碱性黄1 硫磺素T 硫黄素T 硫黄素 T 碱性黄 1 硫代黄素T 硫代磺素T 硫代黄色素 T 2-[4-(二甲基氨基)苯基]-3,6-二甲基苯并噻唑鎓氯化物 |
| 英文别名 | avin T ThiofL C.I. 49005 Thioflavin T Thioflavine T C.I. Basic Yellow 1 LABOTEST-BB LT00451909 Thioflavine T (C.I.No.49005) for synthesis 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-benzothiazoliuchloride 2-[4-(dimethylamino)phenyl]-3,6-dimethylbenzothiazolium chloride Benzothiazolium,2-[4-(dimethylamino)phenyl]-3,6-dimethyl-,chloride 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-1,3-benzothiazol-3-ium chloride |
| CAS | 2390-54-7 |
| EINECS | 219-228-9 |
| 化学式 | C17H19ClN2S |
| 分子量 | 318.86 |
| InChI | InChI=1/C17H19N2S.ClH/c1-12-5-10-15-16(11-12)20-17(19(15)4)13-6-8-14(9-7-13)18(2)3;/h5-11H,1-4H3;1H/q+1;/p-1 |
| 密度 | 1.301g/cm3 at 20℃ |
| 熔点 | 211-212 °C (decomp) |
| 蒸汽压 | 0Pa at 25℃ |
| 溶解度 | 甲醇: 可溶物1mg/mL |
| 存储条件 | Store below +30°C. |
| 外观 | 粉末 |
| 颜色 | Yellow to ochre-yellow |
| BRN | 3922452 |
| MDL号 | MFCD00011944 |
| 体外研究 | Thioflavin T (ThT) is a benzothiazole dye that exhibits enhanced fluorescence upon binding to amyloid fibrils and is commonly used to diagnose amyloid fibrils, both ex vivo and in vitro. In aqueous solutions, Thioflavin T is found to exist as micelles at concentrations commonly used to monitor fibrils by fluorescence assay (~10-20 μM). Specific conductivity changes are measured at varying concentration of Thioflavin T and the critical micellar concentration is calculated to be 4.0±0.5 μM. Changes in the fluorescence excitation and emission of Thioflavin T are also dependent on the micelle formation. The Thioflavin T micelles of 3 nm diameter are directly visualized using atomic force microscopy, and bound Thioflavin T micelles are observed along the fibril length for representative fibrils. Increasing concentration of Thioflavin T above the critical micellar concentration shows increased numbers of micelles bound along the length of the amyloid fibrils. Thioflavin T micelles are disrupted at low pH as observed by atomic force microscopy and fluorescence enhancement upon binding of Thioflavin T to amyloid fibrils also reduced by several-fold upon decreasing the pH to below 3.The micelles of Thioflavin T bind amyloid fibrils leading to enhancement of fluorescence emission. |
| 安全术语 | 24/25 - 避免与皮肤和眼睛接触。 |
| 危险品运输编号 | 2811 |
| WGK Germany | 3 |
| TSCA | Yes |
| 海关编号 | 32041300 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| 上游原料 | 2-(4-氨基苯基)-6-甲基苯并噻唑 |
| 参考资料 展开查看 | 1. 王瑞 朱文清 郑洁 等. 原儿茶酸对人血清白蛋白淀粉样纤维化的抑制作用[J]. 分析科学学报 2020 v.36(02):14-18. 2. 郝徐艺, 罗思, 程淑意,等. 当归芍药散对AD细胞模型铜离子介导的Aβ聚集的影响[J]. 中国实验方剂学杂志, 2019, 25(06):53-59. 3. [IF=4.451] Rong-zu Nie et al."A-type EGCG dimer, a new proanthocyanidins dimer from persimmon fruits, interacts with the amino acid residues of Aβ40 which possessed high aggregation-propensity and strongly inhibits its amyloid fibrils formation."J Funct Foods. 2019 4. [IF=4.079] Rong-zu Nie et al."A-type dimeric epigallocatechin-3-gallate (EGCG) is a more potent inhibitor against the formation of insulin amyloid fibril than EGCG monomer."Biochimie. 2016 Jun;125:204 5. [IF=2.352] Rong-zu Nie et al."Comparison of disaggregative effect of A-type EGCG dimer and EGCG monomer on the preformed bovine insulin amyloid fibrils."Biophys Chem. 2017 Nov;230:1 6. [IF=9.147] Fengzhan Cui et al."Development of pH-responsive emulsions stabilized by whey protein fibrils."Food Hydrocolloid. 2022 Jan;122:107067 7. [IF=3.37] Fengjin Hao et al."Biological evaluation of naturally occurring bulbocodin D as a potential multi-target agent for Alzheimer’s disease."Brain Res Bull. 2020 Dec;165:48 8. [IF=2.506] An Di et al."The Effect of Limited Proteolysis by Trypsin on the Formation of Soy Protein Isolate Nanofibrils."J Chem-Ny. 2020;2020:8185037 9. [IF=10.588] Chao Liang et al.Proteinaceous porous nanofiber membrane-type adsorbent derived from amyloid lysozyme protofilaments for highly efficient lead(II) biologic scavenging.J Hazard Mater. 2022 Mar;425:127886 10. [IF=9.229] Miaomiao Han et al."Amyloid Protein-Biofunctionalized Polydopamine Nanoparticles Demonstrate Minimal Plasma Protein Fouling and Efficient Photothermal Therapy."Acs Appl Mater Inter. 2022;XXXX(XXX):XXX-XXX 11. [IF=13.273] Chao Liang et al."Novel amyloid-like porous lysozyme skeletons as “green” superadsorbent presenting ultrahigh capacity and rapid sequestration towards hazardous Congo red."Chem Eng J. 2022 Aug;441:136005 |
硫黄素T - 简介
硫黄素T，也被称为硫胺素T或维生素B1，是一种重要的维生素。
性质：
硫黄素T是一种水溶性白色结晶性粉末，具有微弱的硫磺味。它是稳定的，在光线、热和酸性条件下相对稳定。它在碱性环境下会迅速降解。
用途：
硫黄素T是一种必需的维生素，对维持人体正常的代谢功能至关重要。硫黄素T还被用于防治硫黄素T缺乏症，该病在饮食中缺乏硫胺素T时会引发。
制法：
硫黄素T可以通过化学合成的方法制备。最常用的方法是以1-甘醇-3-酮为起始原料，经过多步反应制得硫黄素T。硫黄素T也可以通过天然来源，如酵母和谷类中提取得到。
安全信息： 通常情况下，正常剂量的硫黄素T不会产生明显的副作用。过量摄入硫黄素T可能导致胃肠道不适或过敏反应。对于孕妇和有慢性疾病的人群，应在医师的指导下使用。
性质：
硫黄素T是一种水溶性白色结晶性粉末，具有微弱的硫磺味。它是稳定的，在光线、热和酸性条件下相对稳定。它在碱性环境下会迅速降解。
用途：
硫黄素T是一种必需的维生素，对维持人体正常的代谢功能至关重要。硫黄素T还被用于防治硫黄素T缺乏症，该病在饮食中缺乏硫胺素T时会引发。
制法：
硫黄素T可以通过化学合成的方法制备。最常用的方法是以1-甘醇-3-酮为起始原料，经过多步反应制得硫黄素T。硫黄素T也可以通过天然来源，如酵母和谷类中提取得到。
安全信息： 通常情况下，正常剂量的硫黄素T不会产生明显的副作用。过量摄入硫黄素T可能导致胃肠道不适或过敏反应。对于孕妇和有慢性疾病的人群，应在医师的指导下使用。
最后更新：2024-04-09 21:11:58
供应商列表
现货供应
产品名: 2-[4-(二甲基氨基)苯基]-3,6-二甲基苯并噻唑氯化物 去供应商网站查看 询盘CAS: 2390-54-7
产地: 中国上海
包装: 5g
规格: Dye content 75%
价格: 59.00
库存: 现货
电话: 400-900-4166
手机: 18017137653
电子邮件: 3007523013@qq.com
QQ: 3007523013
微信: 18017137653
产品描述: 中文名：2-[4-(二甲基氨基)苯基]-3,6-二甲基苯并噻唑氯化物 英文名:Thioflavine T CAS:2390-54-7 规格:Dye conten 更多
现货供应
产品名: 2-[4-(二甲基氨基)苯基]-3,6-二甲基苯并噻唑氯化物 去供应商网站查看 询盘CAS: 2390-54-7
产地: 中国上海
包装: 5g
规格: Dye content 75%
价格: 59.00
库存: 现货
电话: 400-900-4166
手机: 18017137653
电子邮件: 3007523013@qq.com
QQ: 3007523013
微信: 18017137653
产品描述: 中文名：2-[4-(二甲基氨基)苯基]-3,6-二甲基苯并噻唑氯化物 英文名:Thioflavine T CAS:2390-54-7 规格:Dye conten 更多
硫黄素T的上游原料
您刚刚浏览过
你知道吗？
微信搜索化工百科或扫描下方二维码，添加化工百科小程序，随时随地查信息！