磷雌醇芥钠_化工百科

中文名	雌莫司汀磷酸钠
英文名	Estramustine sodium phosphate
别名	癌腺治磷雌醇芥钠雌莫司丁磷酸钠雌莫司汀磷酸钠雌二醇氮芥磷酸钠雌莫司汀磷酸钠, 抗微管蛋白化疗试剂
英文别名	Estracyt NSC 89199 iumphosphate ESTRAMUSTINE PHOSPHATE SODIUM Estramustine sodium phosphate Estramustine Phosphate Sodium Estramustine disodium phosphate -(dihydrogenphosphate),disodiumsalt Estramustine phosphate disodium salt disodium (17beta)-3-{[bis(2-chloroethyl)carbamoyl]oxy}estra-1,3,5(10)-trien-17-yl phosphate (17-Beta)-Estra-1,3,5(10)-Triene-3,17-Diol 3-(Bis(2-Chloroethyl)Carbamate) 17-(Dihydrogenphosphate) Disodium Salt Estra-1,3,5(10)-triene-3,17-diol (17β)-, 3-[bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate), disodium salt Estra-1,3,5(10)-triene-3,17-diol (17beta)-, 3-[bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate), disodium salt
CAS	52205-73-9
EINECS	257-735-7
化学式	C23H33Cl2NNaO6P
分子量	544.38
InChI	InChI=1/C23H32Cl2NO6P.2Na/c1-23-9-8-18-17-5-3-16(31-22(27)26(12-10-24)13-11-25)14-15(17)2-4-19(18)20(23)6-7-21(23)32-33(28,29)30;;/h3,5,14,18-21H,2,4,6-13H2,1H3,(H2,28,29,30);;/q;2*+1/p-2/t18-,19-,20+,21+,23+;;/m1../s1
沸点	661.2°C at 760 mmHg
闪点	353.7°C
蒸汽压	2.21E-18mmHg at 25°C
溶解度	H2O: 可溶物50mg/mL
存储条件	Inert atmosphere,2-8°C
体外研究	Estramustine phosphate sodium (1 µg/mL) treatment suppressed PC3 cell growth. Estramustine phosphate sodium (2 µg/mL) treatment significantly elevates phosphatidylserine eversion amount on PC3 cells. Estramustine phosphate sodium induces PC3 cell apoptosis. Estramustine phosphate sodium (2 µg/mL) treatment decreases MiR-31 level. Estramustine phosphate odium induces s prostate cancer cell line PC3 apoptosis through reducing miR-31. Estramustine phosphate sodium, a unique antitumour agent, is selectively taken up by prostate cells and exerts antineoplastic effects by interfering with microtubule of dynamics and by reducing plasma levels of testosterone. Estrone and estradiol, products of the metabolism of Estramustine phosphate sodium, have shown antigonadotrophic activity resulting in reduced testosterone levels similar to those achieved after surgical castration.
危险品标志	Xi - 刺激性物品
风险术语	37 - 刺激呼吸系统。
安全术语	26 - 不慎与眼睛接触后，请立即用大量清水冲洗并征求医生意见。
WGK Germany	3
RTECS	KG7350000
海关编号	29242990

磷雌醇芥钠 - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	1.772 ml	8.86 ml	17.72 ml
5 mM	0.354 ml	1.772 ml	3.544 ml
10 mM	0.177 ml	0.886 ml	1.772 ml
5 mM	0.035 ml	0.177 ml	0.354 ml

最后更新：2024-01-02 23:10:35

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CAS: 52205-73-9
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