米卡芬静钠
Micafungin Sodium(sodium 5-((1S,2S)-2-((2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-20-((R)-3-amino-1-hydroxy-3-oxopropyl)-2,11,12,15-tetrahydroxy-6-((R)-1-hydroxyethyl)-16-methyl-5,8,14,19,22,25-hexaoxo-9-(4-(5-(4-(pe)
CAS: 208538-73-2
化学式: C56H72N9NaO23S
| 中文名 | Micafungin Sodium |
| 英文名 | sodium 5-((1S,2S)-2-((2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-20-((R)-3-amino-1-hydroxy-3-oxopropyl)-2,11,12,15-tetrahydroxy-6-((R)-1-hydroxyethyl)-16-methyl-5,8,14,19,22,25-hexaoxo-9-(4-(5-(4-(pe |
| 别名 | 咪克芬净 米卡芬净纳 米卡芬静钠 米卡芬净钠 米卡芬净钠盐 米卡芬净,米卡芬净钠,咪克芬净 MICAFUNGIN SODIUM米卡芬净钠 |
| 英文别名 | FK 463 CS-705 Mycamine Funguard MYCAMINE FUNGUARD Micafungin Sodium Micafungin sodium micafungin sodium Impurity Micafungin SodiuM(FK-463, MycaMine) 1-[(4R,5R)-4,5-Dihydroxy-N2-[4-[5-[4-(pentyloxy)phenyl]-3-isoxazolyl]benzoyl]-L-ornithine]-4-[(4S)-4-hydroxy-4-[4-hydroxy-3-(sulfooxy)phenyl]-L-threonine]pneuMocandin A0 MonosodiuM Salt sodium 5-((1S,2S)-2-((2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-20-((R)-3-amino-1-hydroxy-3-oxopropyl)-2,11,12,15-tetrahydroxy-6-((R)-1-hydroxyethyl)-16-methyl-5,8,14,19,22,25-hexaoxo-9-(4-(5-(4-(pe |
| CAS | 208538-73-2 |
| EINECS | 810-840-7 |
| 化学式 | C56H72N9NaO23S |
| 分子量 | 1294.28 |
| 熔点 | >180°C (dec.) |
| 溶解度 | DMSO (微溶)，甲醇 (微溶)，水 (微溶，超声处理) |
| 存储条件 | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| 稳定性 | 吸湿性 |
| 外观 | 固体 |
| 颜色 | White to Off-White |
| 靶点 | 1,3-beta-D-glucan synthesis |
| 体外研究 | Micafungin是一种抗真菌试剂，不抑制细菌。尽管它不直接抑制细菌，但它能提高G. mellonella的生存率。Micafungin通过阻止Candida albicans中的1,3-β-D-glucan合成、抑制生物膜形成。 |
| 参考资料 展开查看 | 1. Bazzi W, et al. The inhibitory effect of micafungin on biofilm formation by Pseudomonas aeruginosa. Biofouling. 2013 Jul 23.2. Kai H, et al. Synergistic antifungal activity of KB425796-C in combination with micafungin against Aspergillus fumigat us and its efficacy in murine infection models. J Antibiot (Tokyo). 2013 Jun 12.3. Ikeda F, Wakai Y, Matsumoto S, et al. Efficacy of FK463, a new lipopeptide antifungal agent, in mouse models of disseminated candidiasis and aspergillosis. Antimicrob Agents Chemother. 2000;44(3):614-618.4. Tawara S, Ikeda F, Maki K, et al. In vitro activities of a new lipopeptide antifungal agent, FK463, against a variety of clinically important fungi. Antimicrob Agents Chemother. 2000;44(1):57-62.5. Mikamo H, Sato Y, Tamaya T. In vitro antifungal activity of FK463, a new water-soluble echinocandin-like lipopeptide. J Antimicrob Chemother. 2000;46(3):485-487. |
米卡芬静钠 - 配置溶液浓度参考
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 0.774 ml | 3.869 ml | 7.738 ml |
| 5 mM | 0.155 ml | 0.774 ml | 1.548 ml |
| 10 mM | 0.077 ml | 0.387 ml | 0.774 ml |
| 5 mM | 0.015 ml | 0.077 ml | 0.155 ml |
最后更新：2024-01-02 23:10:35
米卡芬静钠 - 细胞实验
Each fungal isolate is incubated statically in yeast-maltose (YM) agar broth for 24 h at 30°C. Cryptococcus neoformans YC203 is grown in YM broth medium for 20 h at 30°C with shaking at 200 r.p.m. A cell suspension is prepared by washing the cultured cells once with sterile saline. A. fumigatus FP1305 is cultured on a potato dextrose agar (PDA) slant for 4 days, and spores are then harvested in sterile saline and collected by filtering through gauze. Antifungal activity against all isolates, with the exception of C. neoformans, is measured by the micro-broth dilution method in 96-well culture plates using RPMI 1640 medium supplemented with l-glutamine, but without sodium bicarbonate, and buffered to pH 7.0 with 0.165 m MOPS. ForC. neoformans, yeast nitrogen base-glucose (YNBD) medium is used. For the assay, the test microorganism is inoculated into each well to yield 1×105 CFU/well, and the plates are then incubated for 20 h or 48 h at 37°C. Two end points are determined by microscopic observation: MEC, which
最后更新：2023-08-16 21:32:38
供应商列表
主打产品现货供应
产品名: Micafungin Sodium 去供应商网站查看 询盘CAS: 208538-73-2
产地: 上海
规格: F872915
价格: 5mg-286,10mg-552,25mg-891,50mg-1620,250mg-1998,1ml-559
库存: 现货
电话: 13816333479/13918391375
手机: 13816333479/13918391375
电子邮件: wangrui@macklin.cn
QQ: 2885703204/285395191
微信: 19863730987/13918391375
现货供应
产品名: Micafungin Sodium 去供应商网站查看 询盘CAS: 208538-73-2
产地: 上海
规格: ≥99%(HPLC)
价格: 2mg 296,5mg 480,10mg 784,25mg 1760,50mg 2320,100mg 4400
库存: 现货
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403
微信: 18301782025
产品描述: Micafungin Sodium ≥99%(HPLC) MedMol 货号：S80530
主打产品现货供应
产品名: Micafungin Sodium 去供应商网站查看 询盘CAS: 208538-73-2
产地: 上海
规格: F872915
价格: 5mg-286,10mg-552,25mg-891,50mg-1620,250mg-1998,1ml-559
库存: 现货
电话: 13816333479/13918391375
手机: 13816333479/13918391375
电子邮件: wangrui@macklin.cn
QQ: 2885703204/285395191
微信: 19863730987/13918391375
现货供应
产品名: Micafungin Sodium 去供应商网站查看 询盘CAS: 208538-73-2
产地: 上海
规格: ≥99%(HPLC)
价格: 2mg 296,5mg 480,10mg 784,25mg 1760,50mg 2320,100mg 4400
库存: 现货
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403
微信: 18301782025
产品描述: Micafungin Sodium ≥99%(HPLC) MedMol 货号：S80530
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