中文名 | 米托胍腙 |
英文名 | mitoguazone |
别名 | 米托瓜酮 丙双脒腙 米托胍腙 丙酮双脒腙 米托胍腙(又名盐酸丙脒腙) |
英文别名 | MGBG Me-GAG methyl-g Methyl-G AI3-60317 Methyl-Gag methyl-gag Mitoguazona BRN 1912590 mitoguazone Mitoguazone Mitoguazonum UNII-OD5Q0L447W Mitoguazonum [INN-Latin] Mitoguazona [INN-Spanish] Methylglyoxal bis(guanylhydrazone) Pyruvaldehyde bis(amidinohydrazone) Methylglyoxal bis(amidinohydrazone) 1,1'-((methylethanediylidene)dinitrilo)diguanidine 1,1'-((Methylethanediylidene)dinitrilo)diguanidine 1,1'-((methylethanediylidene)dinitrilo)di-guanidin Guanidine, 1,1'-((methylethanediylidene)dinitrilo)di- 2,2'-(1-methyl-1,2-ethanediylidene)bis-hydrazinecarboximidamid 2,2'-(1-Methyl-1,2-ethanediylidene)bis(hydrazinecarbimidamide) Hydrazinecarboximidamide, 2,2'-(1-methyl-1,2-ethanediylidene)bis- (9CI) N''-{(1E,2E)-2-[(diaminomethylidene)hydrazono]-1-methylethylidene}carbonohydrazonic diamide (non-preferred name) |
CAS | 459-86-9 |
EINECS | 202-958-7 |
化学式 | C5H12N8 |
分子量 | 184.2 |
InChI | InChI=1/C5H12N8/c1-3(11-13-5(8)9)2-10-12-4(6)7/h2H,1H3,(H4,6,7,12)(H4,8,9,13)/b10-2+,11-3+ |
密度 | 1.55±0.1 g/cm3(Predicted) |
熔点 | 225 °C (decomp) |
沸点 | 323.8±25.0 °C(Predicted) |
闪点 | 217.8°C |
蒸汽压 | 7.99E-08mmHg at 25°C |
折射率 | 1.692 |
酸度系数 | 7.63, 9.05(at 25℃) |
存储条件 | Room Temprature |
物化性质 | 白色结晶,熔点256-257℃(分解)。极易溶于水,在酸性水中较稳定,在碱性介质中不稳定。 |
体外研究 | Mitoguazone competitively inhibits spermidine synthesis in lymphocytes at concentrations as low as 0.5 μg/mL. Levels of 30 μg/mL or more inhibit protein synthesis and mitochondrial respiration. The ability of Mitoguazone to induce apoptosis by inhibiting the polyamine pathway is assessed in three Burkitt's lymphoma cell lines (Raji, Ramos and Daudi) and one prostate carcinoma cell line (MPC 3). Mitoguazone induces apoptosis in all the different human cancer cell lines tested in a concentration- and time-dependent way, and triggers a p53-independent programmed cell death in the human breast cancer MCF7 cell line. |
体内研究 | The influence of different stages of leukemia P388 on the pharmacokinetics of the antineoplastic agent Mitoguazone in mice is investigated. Independent of the tumor stage investigated, the total clearance of mitoguazone is slightly reduced reflecting a moderate increase of AUC in the serum of leukemia-bearing animals. Furthermore, in an advanced tumor stage the drug levels in kidneys, liver, spleen and serum are found to be elevated to some extent in comparison to tumor-free controls in contrast to an earlier stage of leukemia. |
上游原料 | 丙酮醛 氨基胍碳酸盐 |
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