中文名 | 红景天苷 |
英文名 | Salidroside |
别名 | 毛柳甙 毛柳苷 红景天苷 红景天甙 红景天提取物 红景天苷(标准品) 红景天提取物SALIDROSIDE 红景天苷 2-(4-羟基苯基)乙基-Β-D-葡萄糖苷 |
英文别名 | rhodosin Salidroside Rhodioloside SALIDROSIDE(P) RhodiolaExtract Rhodiola Extract Q439 Salidroside TWEEN 20 EXTRA PURE Salidroside Extract. Rhodiola Rosca Extract Rhodiola rosea extract RhodiolaCrenulataExtract Smilax aristolochiaefolia, ext. Salidroside, froM Herba rhodiolae glucopyranoside,p-hydroxyphenethyl 2-(4-hydroxyphenyl)ethyl beta-D-glucopyranoside 2-(4-HYDROXYPHENYL)ETHYL-BETA-D-GLUCOPYRANOSIDE beta-d-glucopyranoside,2-(4-hydroxyphenyl)ethyl 2-(4-Hydroxyphenyl)ethyl betta-D-glucopyranoside |
CAS | 10338-51-9 97404-52-9 |
EINECS | 695-621-2 |
化学式 | C14H20O7 |
分子量 | 300.3 |
InChI | InChI=1/C14H20O7/c15-7-10-11(17)12(18)13(19)14(21-10)20-6-5-8-1-3-9(16)4-2-8/h1-4,10-19H,5-7H2/t10-,11-,12+,13-,14-/m1/s1 |
InChIKey | ILRCGYURZSFMEG-RKQHYHRCSA-N |
密度 | 1.46±0.1 g/cm3(Predicted) |
熔点 | 159~160℃ |
沸点 | 549.5±50.0 °C(Predicted) |
比旋光度 | (c, 1.26 in H2O)-32.1 |
闪点 | 286.2°C |
蒸汽压 | 6.54E-13mmHg at 25°C |
溶解度 | 甲醇 (微溶) 、吡啶 (微溶) |
折射率 | 1.628 |
酸度系数 | 9.98±0.15(Predicted) |
存储条件 | Sealed in dry,Room Temperature |
外观 | 整洁 |
颜色 | Off-White |
物化性质 | 来源于景天科植物大花红景天Rhodiola crenulata(Hook.f.et.Thoms.)H.Ohba的干燥根及根茎。 |
MDL号 | MFCD00210553 |
危险品标志 | Xi - 刺激性物品 |
风险术语 | 36 - 刺激眼睛。 |
安全术语 | 26 - 不慎与眼睛接触后,请立即用大量清水冲洗并征求医生意见。 |
WGK Germany | 3 |
RTECS | LZ5901900 |
海关编号 | 29389090 |
参考资料 展开查看 | 1. 叶妙勇 赵凡 马轲 等. H2O2对大鼠阴茎海绵体平滑肌细胞connexin43蛋白表达的影响及红景天苷的干预作用[J]. 中华男科学杂志 2019(8). 2. 李王莹 王兴芳 李军 等. 不同溶剂提取唐古特红景天化学成分的比较及红景天苷含量的测定[J]. 甘肃农业大学学报 2014(5):63-69. 3. 刘树民 张帅男 张宁 等. 刺五加潜在靶点网络辅助活性成分效应的发现[J]. 中药药理与临床 2017(05):127-132. 4. 纪鑫, 刘晓谦, 李春,等. 基于UPLC技术的女贞子中主要成分炮制变化规律研究及酒女贞子特色质量标准的探讨[J]. 中国中药杂志, 2018, 43(24):128-134. 5. 徐锋, 杨烨, 舒秋娥,等. 大血藤的HPLC指纹图谱[J]. 中国实验方剂学杂志, 2013. 6. 徐锋, 杨烨, 舒秋娥,等. 大血藤药材的UPLC指纹图谱分析[J]. 中国实验方剂学杂志, 2013. 7. 纪鑫, 刘晓谦, 肖苏萍,等. 女贞子中非三萜类成分的定性定量研究[J]. 中国中药杂志, 2019, 044(008):1615-1622. 8. 李晶, 朱娜, 郑飞,等. 红参红景天混合物提取工艺及其抗疲劳作用[J]. 食品工业科技, 2019, 040(016):181-185,191. 9. 秦雪琴,陈悦,雷尚芳,陈德森.红景天甙防治兔肝移植术后疲劳综合征的实验研究[J].海南医学,2017,28(12):1893-1896. 10. 陈红红, 莫书荣, 吴忧. 红景天苷与黄芪注射液协同对人肝癌HepG2细胞增殖的抑制作用[J]. 基因组学与应用生物学, 2016, 35(009):2241-2245. 11. 黄媛恒,谢剑,黄创明,韦仙琴,林心媚,刘芳铭,李映新.红景天苷体外灌流对大鼠心肌细胞膜钠通道电流的影响[J].山东医药,2016,56(07):31-33. 12. 吴蓉,张薇,陈璐瑶,曹君,苏二正.红景天苷和酪醇的DES同步提取优化和回收[J].精细化工,2019,36(05):865-874. 13. 马莹,刘晶,潘涛.红景天苷对H9c2心肌细胞应激高糖损伤的保护作用及机制研究[J].南京中医药大学学报,2019,35(04):442-447. 14. 吕红梅,郭云辉,赵云波.红景天苷对人肝癌细胞HepG-2的作用及机制研究[J].当代医学,2013,19(26):29-30. 15. 韦丽兰,莫书荣.红景天苷对人胃癌细胞SGC-7901抑瘤作用的体外实验研究[J].山东大学学报(医学版),2015,53(12):12-15+32. 16. 高建峰, 赵诗洁, 周立,等. 红景天苷对低氧条件下培养的鸡胚肺微血管内皮细胞HIF-1α表达水平的影响[J]. 中国兽医学报, 2016, 36(10):1733-1736. 17. 颜俊锋,赵剑锋,张高岳,黄晓军,陈刚,吕伯东.红景天苷对低氧环境下大鼠阴茎海绵体平滑肌细胞缝隙连接蛋白43表达的影响[J].中华男科学杂志,2016,22(08):725-729. 18. 高丽丽, 吴成翰, 蔡伟武. 红景天苷对大鼠脑出血后神经功能的影响[J]. 中国卫生标准管理, 2019, 10(02):118-121. 19. 高瑾, 罗伟, 王钦,等. 红景天苷对宫颈癌Siha细胞增殖及IM P3表达的影响[J]. 重庆医学, 2016, 45(027):3849-3851. 20. 章丽霞,王涛,牛彩琴.红景天苷对小鼠宫颈癌移植瘤中Eag1表达的影响和意义[J].重庆医学,2017,46(25):3470-3472+3476. 21. 黄玉哲, 刘丽霞, 邱雨童,等. 红景天苷对慢性肾衰竭大鼠保护作用机制的研究[J]. 河北医科大学学报, 2019(8):882-885. 22. 张立超, 王晨宇, 曹慧芳,等. 红景天苷对梗阻性黄疸大鼠的肝保护作用及机制探讨[J]. 山东医药, 2015, 000(046):32-33. 23. 周丽萍,李馨,唐超园,葛婷婷,林德菊,胡传钦,余勤.红景天苷对间充质干细胞缺氧损伤后增殖及抗氧化能力影响的初步研究[J].浙江中医药大学学报,2016,40(09):643-647. 24. 张丹,曹丽华,王镇山,徐明韬,李孟露,冯浩珅,才旭,于娜,康健.红景天苷对香烟烟雾诱导的慢性阻塞性肺疾病大鼠骨骼肌功能影响的研究[J].大连医科大学学报,2019,41(03):199-204+209. 25. 刘莲, 崔书彦, 王晨雪, et al. 红景天苷联合阿霉素对裸鼠HepG2肝癌的影响研究[J]. 现代中西医结合杂志, 2019(21). 26. 朱琳,王彦军,俞天虹,罗光华,魏江,于洋,贾方,孙建辉.红景天苷通过抑制内质网应激减少高同型半胱氨酸诱导的人脐静脉内皮细胞损伤[J].中国动脉硬化杂志,2015,23(01):5-10. 27. 黄菲菲,李耀浙,张婷,王良兴,黄晓颖.红景天苷通过抑制氧化应激防治大鼠低氧性肺动脉高压[J].中国病理生理杂志,2018,34(03):500-506. 28. 王晴, 王英姿, 李友林,等. 红鹤方制剂HPLC指纹图谱研究[J]. 北京中医药大学学报, 2016, 39(001):40-45. 29. 俞天虹,朱琳,赵蓉,王彦军,孙建辉,贾方.腺苷酸蛋白激酶活化在红景天苷抑制同型半胱氨酸诱导的人脐静脉内皮细胞内质网应激中的作用[J].中华中医药学刊,2017,35(10):2558-2562. 30. 刘文静, 曹妍, 宋青青,等. 荒漠肉苁蓉花及木质化茎的化学成分定性分析[J]. 中国中药杂志, 2018, 43(018):3708-3714. 31. 李钇垚, 蹇瑜璇, 窦纯,等. 红景天苷对呋喃所致小鼠肝损伤的保护作用研究[J]. 农产品加工(上半月), 2019(15). 32. 宋青青,张珂,李婷,管朋维,龚兴成,许霞,李军,屠鹏飞,宋月林.反相-亲水作用色谱-定制多反应监测法同步测定肉苁蓉多成分含量[J].分析化学,2020,48(11):1573-1593. 33. 马玲,王楠,杜丽.红景天苷对低氧环境下大鼠心肌自噬的影响[J].中国临床药理学杂志,2020,36(21):3450-3453. 34. Yibo Feng, Xiaojuan Zhao, Fang Lv, Jinqiu Zhang, Bihua Deng, Yanhong Zhao, Yuanliang Hu, Deyun Wang, Jiaguo Liu, Yu Lu, Ruonan Bo, Zhenguang Liu, "Optimization on Preparation Conditions of Salidroside Liposome and Its Immunological Activity on PCV-2 in Mic 35. Yuan Yuan, Xuan Wu, Xu Zhang, Yilin Hong, Haiyang Yan,Ameliorative effect of salidroside from Rhodiola Rosea L. on the gut microbiota subject to furan-induced liver injury in a mouse model,Food and Chemical Toxicology,Volume 125,2019,Pages 333-340,IS 36. Hu, Fangli, Xiaoyan Liao, and Zilin Chen. "Determination of three phenylethanoid glycosides in Osmanthus fragrans fruits by high‐performance liquid chromatography with fluorescence detection." Journal of separation science 41.21 (2018): 3995-4000. https:// 37. Nan, Xingmei, et al. "Bioactive fraction of Rhodiola algida against chronic hypoxia-induced pulmonary arterial hypertension and its anti-proliferation mechanism in rats." Journal of ethnopharmacology 216 (2018): 175-183.https://doi.org/10.1016/j.jep.2018.0 38. [IF=6.06] Jiahong Han et al."Compatibility effects of ginseng and Ligustrum lucidum Ait herb pair on hematopoietic recovery in mice with cyclophosphamide-induced myelosuppression and its material basis."J Ginseng Res. 2020 Mar;44:291 39. [IF=6.023] Yuan Yuan et al."Ameliorative effect of salidroside from Rhodiola Rosea L. on the gut microbiota subject to furan-induced liver injury in a mouse model."Food Chem Toxicol. 2019 Mar;125:333 40. [IF=5.279] Yirong Jiang et al."Phenylethanoid Glycoside Profiles and Antioxidant Activities of Osmanthus fragrans Lour. Flowers by UPLC/PDA/MS and Simulated Digestion Model."J Agr Food Chem. 2016;64(12):2459–2466 41. [IF=5.279] Xiaoyan Liao et al."Identification and Quantitation of the Bioactive Components in Osmanthus fragrans Fruits by HPLC-ESI-MS/MS."J Agr Food Chem. 2018;66(1):359–367 42. [IF=4.556] Maiquan Li et al."Neuroprotective Effects of Four Phenylethanoid Glycosides on H2O2-Induced Apoptosis on PC12 Cells via the Nrf2/ARE Pathway."Int J Mol Sci. 2018 Apr;19(4):1135 43. [IF=3.046] Liwei Dong et al."Echinacoside induces apoptotic cancer cell death by inhibiting the nucleotide pool sanitizing enzyme MTH1."Oncotargets Ther. 2015; 8: 3649–3664 44. [IF=2.629] Zhang Bu-Chun et al."Salidroside Decreases Atherosclerotic Plaque Formation in Low-Density Lipoprotein Receptor-Deficient Mice."Evid-Based Compl Alt. 2012;2012:607508 45. [IF=2.371] Wang Xu-Lei et al."Salidroside Improves Doxorubicin-induced Cardiac Dysfunction by Suppression of Excessive Oxidative Stress and Cardiomyocyte Apoptosis."J Cardiovasc Pharm. 2013 Dec;62(6):512-523 46. [IF=2.1] Lin Sun et al."Salidroside slows the progression of EA.hy926 cell senescence by regulating the cell cycle in an atherosclerosis model."Mol Med Rep. 2018 Jan;17(1):257-263 47. [IF=1.851] Xujiao Huang et al."Salidroside protects PC12 cells from Aβ1‑40‑induced cytotoxicity by regulating the nicotinamide phosphoribosyltransferase signaling pathway."Mol Med Rep. 2017 Sep;16(3):2700-2706 48. [IF=1.297] Shi Kai et al."Salidroside protects retinal endothelial cells against hydrogen peroxide-induced injury via modulating oxidative status and apoptosis."Biosci Biotech Bioch. 2015 Sep;79(9):1406-1413 49. [IF=9.783] Huiping Bi et al."Biosynthesis of a rosavin natural product in Escherichia coli by glycosyltransferase rational design and artificial pathway construction."Metab Eng. 2022 Jan;69:15 50. [IF=5.076] Zhang Zepeng et al."Shen-Hong-Tong-Luo Formula Attenuates Macrophage Inflammation and Lipid Accumulation through the Activation of the PPAR-γ/LXR-α/ABCA1 Pathway."Oxid Med Cell Longev. 2020;2020:3426925 51. [IF=4.679] Yuan Yuan et al."Salidroside ameliorates liver metabonomics in relation to modified gut-liver FXR signaling in furan-induced mice."Food Chem Toxicol. 2020 Jun;140:111311 52. [IF=4.237] Xiaoping Chen et al."Salidroside ameliorated hypoxia‐induced tumorigenesis of BxPC‐3 cells via downregulating hypoxia‐inducible factor (HIF)‐1α and LOXL2."J Cell Biochem. 2020 Jan;121(1):165-173 53. [IF=4.221] Yuan Yuan et al."Salidroside alleviates liver inflammation in furan-induced mice by regulating oxidative stress and endoplasmic reticulum stress."Toxicology. 2021 Sep;461:152905 54. [IF=4.142] Wang Chenxi et al."Systematic quality evaluation of Peiyuan Tongnao capsule by offline two-dimensional liquid chromatography/quadrupole-Orbitrap mass spectrometry and adjusted parallel reaction monitoring of quality markers."Anal Bioanal Chem. 2019 Nov;4 55. [IF=3.373] Tian Tian et al."Non-targeted screening of pyranosides in Rhodiola crenulata using an all ion fragmentation-exact neutral loss strategy combined with liquid chromatography-quadrupole time-of-flight mass spectrometry."Phytochem Analysis. 2021 Nov;32(6):103 56. [IF=2.942] Zhang Dan et al."Salidroside mitigates skeletal muscle atrophy in rats with cigarette smoke-induced COPD by up-regulating myogenin and down-regulating myostatin expression."Bioscience Rep. 2019 Nov;39(11):BSR20190440 57. [IF=2.896] Zhang Ke et al."Online energy-resolved MS boosts the potential of LC-MS towards metabolite characterization of salidroside and tyrosol."Anal Methods-Uk. 2020 Nov;12(42):5120-5127 58. [IF=2.749] Xue Luan et al."Salidroside Mitigates Airway Inflammation in Asthmatic Mice via the AMPK/Akt/GSK3β Signaling Pathway."Int Arch Allergy Imm. ;:1-11 59. [IF=2.611] Zhou Liping et al."Salidroside-pretreated mesenchymal stem cells contribute to neuroprotection in cerebral ischemic injury in vitro and in vivo."J Mol Histol. 2021 Dec;52(6):1145-1154 60. [IF=1.902] Chenxi Wang et al."Multiple component-pharmacokinetic studies on 10 bioactive constituents of Peiyuan Tongnao capsule using parallel reaction monitoring mode."Biomed Chromatogr. 2021 Oct;35(10):e5153 61. [IF=1.902] Danjie Zhang et al."Analysis of chemical variations between raw and wine-processed Ligustri Lucidi Fructus by ultra-high-performance liquid chromatography–Q-Exactive Orbitrap/MS combined with multivariate statistical analysis approach."Biomed Chromatogr. 62. [IF=1.448] Ruoshui Li et al."Salidroside prevents tumor necrosis factor‑α‑induced vascular inflammation by blocking mitogen‑activated protein kinase and NF‑κB signaling activation."Exp Ther Med. 2019 Nov;18(5):4137-4143 63. [IF=3.645] Danjie Zhang et al.Systematic characterization of the absorbed components of Ligustri Lucidi Fructus and their metabolic pathways in rat plasma by ultra-high-performance liquid chromatography-Q-Exactive Orbitrap tandem mass spectrometry combined with netw 64. [IF=3.307] Yue-Jun Hao et al."Selection of initial culture medium in fed-batch bioreactor culture of Rhodiola sachalinensis cells."J Biotechnol. 2022 Feb;346:15 65. [IF=1.134] Ting-Ting ZHANG et al."Construction of ERGO film modified electrode and its combination with HPLC in determination of five active components in Osmanthus fragrans fruits."CHINESE JOURNAL OF ANALYTICAL CHEMISTRY. 2022 Jul;50:100109 66. [IF=4.575] Shu Xing-Mei et al."Salidroside alleviates cadmium-induced toxicity in mice by restoring the notch/HES-1 and RIP1-driven inflammatory signaling axis."INFLAMMATION RESEARCH. 2022 May;:1-12 |
微信搜索化工百科或扫描下方二维码,添加化工百科小程序,随时随地查信息!