中文名 | 细叶远志苷A |
英文名 | Tenuifoliside A |
别名 | 远志糖苷A 远志蔗糖酯A 细叶远志苷A 细叶远志甙 A 细叶远志苷 A 细叶远志苷A标准品 细叶远志苷A对照品 细叶远志苷A(远志糖苷A) |
英文别名 | Tenuifoliside A α-D-Glucopyranoside, 3-O-[(2E)-1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propen-1-yl]-β-D-fructofuranosyl, 6-(4-hydroxybenzoate) (E)-(3,4,5-trihydroxy-6-((4-hydroxy-3-((3-(4-hydroxy-3,5-dimethoxyphenyl)acryloyl)oxy)-2,5-bis(hydroxymethyl)tetrahydrofuran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)methyl 4-hydroxybenzoate |
CAS | 139726-35-5 |
化学式 | C31H38O17 |
分子量 | 682.63 |
密度 | 1.55±0.1 g/cm3 (20 ºC 760 Torr) |
沸点 | 917.3±65.0 °C(Predicted) |
比旋光度 | -20.5 (c, 1.52 in MeOH) |
溶解度 | 可溶于水,DMSO,甲醇 |
酸度系数 | 8.13±0.15(Predicted) |
存储条件 | 2-8℃ |
敏感性 | Easily absorbing moisture |
外观 | 白色粉末 |
体外研究 | Tenuifoliside A (6-30 μM; 24 hours) increases the C6 cells viability significantly by concentration dependent manner. But the viability of the 60 μM treatment group is suppressed. Only 60 μM TFSA induced the release of LDH, shows a toxic effect. Tenuifoliside A (10 μM; 2, 5, 7, 10, 15, 30, 45 and 60 mins) elicits a rapid (starting at 2 min) and marked induction of ERK1/2 phosphorylation peaking at 5 min. And,the enhanced levels of phospho-ERK induced by TFSA are partially blocked by ERK inhibitor U0126. |
参考资料 展开查看 | 1. 陈颖,禹鹏鑫,丁辉,荆瑶瑶,张丽娟,余河水,杨建会,宋新波,李正.经典名方开心散不同温度高压蒸汽灭菌条件下9种指标成分含量变化研究[J].中草药,2021,52(04):976-981. 2. [IF=6.558] Qingqing Song et al."Binary code, a flexible tool for diagnostic metabolite sequencing of medicinal plants."Anal Chim Acta. 2019 Dec;1088:89 3. [IF=3.935] Ruimei Lin et al."Global identification and determination of the major constituents in Kai-Xin-San by ultra-performance liquid chromatography-quadrupole-Orbitrap mass spectrometry and gas chromatography-mass spectrometry."J Pharmaceut Biomed. 2021 Nov;206 |
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