绞股蓝皂苷XVII
七叶胆苷XVII(GypenosideXVII)
CAS: 80321-69-3
化学式: C48H82O18
| 中文名 | 七叶胆苷XVII |
| 英文名 | GypenosideXVII |
| 别名 | 七叶胆苷ⅩⅦ 七叶胆苷XVI 七叶胆苷XVII 七叶胆皂苷XVII 绞股蓝皂苷XVII 七叶胆苷XVII对照品, 七叶胆苷XVII(标准品) 七叶胆苷XVII(绞股蓝皂苷XVII) |
| 英文别名 | GP-17 Gynosaponin S Gypenoside ⅩⅦ GypenosideXVII GYPENOSIDE-XVII Gypenoside XVII (Gynosaponin S) 3β-(β-D-Glucopyranosyloxy)-12β-hydroxy-5α-dammar-24-en-20-yl 6-O-β-D-glucopyranosyl-β-D-glucopyranoside β-D-Glucopyranoside, (3β,12β)-3-(β-D-glucopyranosyloxy)-12-hydroxydammar-24-en-20-yl 6-O-β-D-glucopyranosyl- (3beta,12beta)-3-(beta-D-Glucopyranosyloxy)-12-hydroxydammar-24-en-20-yl 6-O-beta-D-glucopyranosyl-beta-D-glucopyranoside |
| CAS | 80321-69-3 |
| 化学式 | C48H82O18 |
| 分子量 | 947.15 |
| 密度 | 1.38 |
| 熔点 | >183°C (dec.) |
| 沸点 | 1013.5±65.0 °C(Predicted) |
| 比旋光度 | +18.3°（c=0.30,MeOH） |
| 溶解度 | DMSO (微溶) 、甲醇 (微溶) 、吡啶 (微溶) |
| 酸度系数 | 12.90±0.70(Predicted) |
| 存储条件 | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| 稳定性 | 吸湿性 |
| 敏感性 | Easily absorbing moisture |
| 外观 | 固体 |
| 颜色 | White to Off-White |
| 物化性质 | 白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于绞股蓝（七叶胆）Fiveleaf Gynostemma Herb。 |
| MDL号 | MFCD10566703 |
| 体外研究 | The ability of Gypenoside XVII (GP-17) to prevent Ox-LDL-induced cytotoxicity is detected by cell viability assays. Gypenoside XVII does not demonstrate any cytotoxicity in HUVECs. Gypenoside XVII can protect HUVECs against Ox-LDL-induced apoptosis. Gypenoside XVII dose-dependently mitigates the toxic effect of Ox-LDL on HUVEC viability. The viability of HUVECs is significantly higher than that of other groups at 50 μg/mL Gypenoside XVII . |
| 体内研究 | Body weights are measured as physical measures of hormone bioactivity. Mean body weights are significantly higher in every group compared to that of the control, but there is no significant difference in body weight between the different treatments during the 10-week feeding. The mouse plasma lipid levels are also measured at the end of 10 weeks of a high-fat diet. Circulating levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) are significantly increased in the treated groups of ApoE -/- mice compared with those of the C57BL/6J control group; Gypenoside XVII (GP-17) and Probucol treatment substantially decreases both of these parameters relative to those of the ApoE -/- model group. |
| 参考资料 展开查看 | 1. 杨美超 吴景东. 七叶胆苷ⅩⅦ对UV照射引起的小鼠内质网应激相关分子的影响[J]. 成都中医药大学学报 2019(2). 2. 王婷欧,吴景东.绞股蓝七叶胆苷XVII对光老化小鼠血清中前列腺素2、环氧酶2水平及皮肤组织中MMP-1表达的影响[J].中医学报,2019,34(05):1012-1015. 3. 李雪晴, 李丽, 刘秀峰,等. 三七皂苷的人肠道菌群体外代谢研究[J]. 药物生物技术, 2017(03):34-39. 4. [IF=3.935] Hong Zhang et al."A multidimensional analytical approach based on time-decoupled online comprehensive two-dimensional liquid chromatography coupled with ion mobility quadrupole time-of-flight mass spectrometry for the analysis of ginsenosides from white a 5. [IF=3.645] Mengmeng Jia et al."UHPLC coupled with mass spectrometry and chemometric analysis of Kang-Ai injection based on the chemical characterization, simultaneous quantification, and relative quantification of 47 herbal alkaloids and saponins."J Sep Sci. 2020 Ju 6. [IF=3.361] Yuhao Zhang et al."An integrated approach for structural characterization of Gui Ling Ji by traveling wave ion mobility mass spectrometry and molecular network."Rsc Adv. 2021 Apr;11(26):15546-15556 7. [IF=2.629] Zhang Meiyu et al."In Vitro Transformation of Protopanaxadiol Saponins in Human Intestinal Flora and Its Effect on Intestinal Flora."Evid-Based Compl Alt. 2021;2021:1735803 |
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