中文名 | 美决明子素 |
英文名 | obtusifolin |
别名 | 钝叶素 决明蒽醌 美决明子素 美决明子素对照品 美决明子素(标准品) 决明蒽醌(美决明子素) 2,8-二羟基-1-甲氧基-3-甲基蒽醌 |
英文别名 | Obtusifolin obtusifolin Obtusifolin (anthraquinone) 2,8-Dihydroxy-1-Methoxy-3-Methylanthraquinone Anthraquinone, 2,8-dihydroxy-1-methoxy-3-methyl- 2,8-dihydroxy-1-methoxy-3-methylanthracene-9,10-dione 2,8-Dihydroxy-1-methoxy-3-methyl-9,10-anthracenedione 9,10-Anthracenedione, 2,8-dihydroxy-1-methoxy-3-methyl- |
CAS | 477-85-0 |
EINECS | 805-819-4 |
化学式 | C16H12O5 |
分子量 | 284.26 |
密度 | 1.448±0.06 g/cm3 (20 ºC 760 Torr) |
熔点 | 242-243℃ |
沸点 | 528.0±50.0 °C(Predicted) |
溶解度 | 可溶于DMSO、甲醇等溶液。 |
酸度系数 | 6.60±0.20(Predicted) |
存储条件 | 2-8℃ |
外观 | 黄色粉末 |
物化性质 | 橙黄色结晶粉末,可溶于甲醇、乙醇、DMSO等有机溶剂,来源于决明子。 |
MDL号 | MFCD18452296 |
体外研究 | Obtusifolin (1, 10, 100 μM) inhibits MUC5AC gene expression induced by EGF, PMA, or TNF-α in NCI-H292 cells. |
参考资料 展开查看 | 1. Xie, Li, et al. "Development of an UHPLC-MS/MS method for comparative pharmacokinetics of nine anthraquinones in rats and application to dosage conversion between different Semen Cassiae forms." Journal of pharmaceutical and biomedical analysis 174 (2019): 2. [IF=3.935] Li Xie et al."Development of an UHPLC-MS/MS method for comparative pharmacokinetics of nine anthraquinones in rats and application to dosage conversion between different Semen Cassiae forms."J Pharmaceut Biomed. 2019 Sep;174:696 |
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