美西他滨
R-7128(R-7128)
CAS: 940908-79-2
化学式: C18H26FN3O6
| 中文名 | R-7128 |
| 英文名 | R-7128 |
| 别名 | 美西他滨 化合物GALUNISERTIB (2'R)- 2'-去氧-2'-氟-2'-甲基胞苷 3',5'-双(2-甲基丙酸)酯 |
| 英文别名 | R-7128 R 7128 RG 7128 Mericitabine MERICITABINE PSI 6130 diisobutyrate PSI 6130 DIISOBUTYRATE (2'R)- 2'-Deoxy-2'-fluoro-2'-methylcytidine 3',5'-bis(2-methylpropanoate) Cytidine, 2'-deoxy-2'-fluoro-2'-methyl-, 3',5'-bis(2-methylpropanoate), (2'R)- |
| CAS | 940908-79-2 |
| 化学式 | C18H26FN3O6 |
| 分子量 | 399.41 |
| 密度 | 1.36 |
| 沸点 | 496.1±55.0 °C(Predicted) |
| 溶解度 | 溶于DMSO |
| 酸度系数 | 4.26±0.10(Predicted) |
| 存储条件 | -20℃ |
| 产品用途 | Mericitabine is a nucleoside HCV NS5B polymerase inhibitor. It acts as an RNA chain terminator and prevents the elongation of RNA transcripts during replication. |
| 靶点 | HCV NS5B polymerase, |
| 参考资料 展开查看 | 1: Wedemeyer H, Forns X, Hézode C, Lee SS, Scalori A, Voulgari A, Le Pogam S, Nájera I, Thommes JA. Mericitabine and Either Boceprevir or Telaprevir in Combination with Peginterferon Alfa-2a plus Ribavirin for Patients with Chronic Hepatitis C Genotype 1 Infection and Prior Null Response: The Randomized DYNAMO 1 and DYNAMO 2 Studies. PLoS One. 2016 Jan 11;11(1):e0145409. doi: 10.1371/journal.pone.0145409. eCollection 2016. PubMed PMID: 26752189; PubMed Central PMCID: PMC4713467. 2: Feng JY, Xu Y, Barauskas O, Perry JK, Ahmadyar S, Stepan G, Yu H, Babusis D, Park Y, McCutcheon K, Perron M, Schultz BE, Sakowicz R, Ray AS. Role of Mitochondrial RNA Polymerase in the Toxicity of Nucleotide Inhibitors of Hepatitis C Virus. Antimicrob Agents Chemother. 2015 Nov 23;60(2):806-17. doi: 10.1128/AAC.01922-15. PubMed PMID: 26596942. 3: Canini L, Guedj J, Chatterjee A, Lemenuel-Diot A, Smith PF, Perelson AS. Modelling the interaction between danoprevir and mericitabine in the treatment of chronic HCV infection. Antivir Ther. 2015 Nov 10. doi: 10.3851/IMP3006. [Epub ahead of print] PubMed PMID: 26555159. 4: Jensen DM, Brunda M, Elston R, Gane EJ, George J, Glavini K, Hammond JM, Le Pogam S, Nájera I, Passe S, Piekarska A, Rodriguez I, Zeuzem S, Chu T; ANNAPURNA study investigators. Interferon-free regimens containing setrobuvir for patients with genotype 1 chronic hepatitis C: a randomized, multicenter study. Liver Int. 2015 Oct 31. doi: 10.1111/liv.12997. [Epub ahead of print] PubMed PMID: 2 |
美西他滨 - 配置溶液浓度参考
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.504 ml | 12.518 ml | 25.037 ml |
| 5 mM | 0.501 ml | 2.504 ml | 5.007 ml |
| 10 mM | 0.25 ml | 1.252 ml | 2.504 ml |
| 5 mM | 0.05 ml | 0.25 ml | 0.501 ml |
最后更新：2024-01-02 23:10:35
供应商列表
现货供应
产品名: Mericitabine 去供应商网站查看 询盘CAS: 940908-79-2
产地: 上海
规格: M876276
价格: 10mg-2214,5mg-1624
库存: 15天内发货
电话: 13816333479/17821173903
手机: 13816333479/17821173903
电子邮件: wangrui@macklin.cn
QQ: 2885703204/288570320
微信: 19863730987/17821173903
现货供应
产品名: Mericitabine 去供应商网站查看 询盘CAS: 940908-79-2
产地: 上海
规格: M876276
价格: 10mg-2214,5mg-1624
库存: 15天内发货
电话: 13816333479/17821173903
手机: 13816333479/17821173903
电子邮件: wangrui@macklin.cn
QQ: 2885703204/288570320
微信: 19863730987/17821173903
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