肝素锂
肝素锂(Heparin Lithium)
CAS: 9045-22-1
化学式: n.a.
| 中文名 | 肝素锂 |
| 英文名 | Heparin Lithium |
| 别名 | 肝素锂 胆素锂 肝素锂盐 肝素锂(注射级) 肝素 锂盐 来源于猪肠粘膜 |
| 英文别名 | LithiuM heparin HEPARIN LITHIUM Heparin Lithium HEP, LI, PORCINE HEPARIN LITHIUM SALT PORCINE HEPARIN, LITHIUM Heparin, LithiuM salt USP HEPARIN PORCINE LITHIUM SALT HEPARIN, LITHIUM SALT, PORCINE heparin lithium from porcine*intestinal mucosa Heparin, Lithium Salt, PorcineIntestinal Mucosa Heparin lithium salt from porcine intestinal mucosa |
| CAS | 9045-22-1 |
| EINECS | 686-293-1 |
| 化学式 | n.a. |
| 存储条件 | +15C to +30C |
| 外观 | 白色固体 |
| MDL号 | MFCD00131308 |
| 体外研究 | Heparin is a potent anticoagulant drug based on its ability to accelerate the rate at which antithrombin inhibits serine proteases in the blood coagulation cascade. Heparin interactes most tightly with peptides containing a complementary binding site of high positive charge density. Heparin resembles DNA as both are highly charged linear polymers that behave as polyelectrolytes. Heparin is believed to function as an anticoagulant primarily through its interaction with AT III by enhancing AT-III-mediated inhibition of blood coagulation factors, including thrombin and factor Xa. Heparin binds to AT III and thrombin in a ternary complex, increasing the bimolecular rate constant for the inhibition of thrombin by a factor of 2000. Heparin is principally located in the granules of tissue mast cells that are closely associated with the immune response. Heparin makes numerous contacts with both FGF-2 and FGFR-1 stabilizing FGF–FGFR binding. Heparin also makes contacts with the FGFR-1 of the adjacent FGF–FGFR complex, thus seeming to promote FGFR dimerization. |
| 危险品标志 | Xi - 刺激性物品 |
| 风险术语 | 36/37/38 - 刺激眼睛、呼吸系统和皮肤。 |
| 安全术语 | S22 - 切勿吸入粉尘。 S24/25 - 避免与皮肤和眼睛接触。 S36 - 穿戴适当的防护服。 S26 - 不慎与眼睛接触后，请立即用大量清水冲洗并征求医生意见。 |
| WGK Germany | 3 |
| RTECS | MI0700000 |
| FLUKA BRAND F CODES | 3-10 |
| 海关编号 | 29319090 |
| 参考资料 展开查看 | 1. [IF=9.933] Donghai Li et al.Delivery of MiR335-5p-Pendant Tetrahedron DNA Nanostructures Using an Injectable Heparin Lithium Hydrogel for Challenging Bone Defects in Steroid-Associated Osteonecrosis.Advanced Healthcare Materials.2021 Nov 01 2. [IF=13.273] Donghai Li et al."Osteoimmunomodulatory injectable Lithium-Heparin hydrogel with Microspheres/TGF-β1 delivery promotes M2 macrophage polarization and osteogenesis for guided bone regeneration."Chem Eng J. 2022 May;435:134991 |
供应商列表
您刚刚浏览过
你知道吗？
微信搜索化工百科或扫描下方二维码，添加化工百科小程序，随时随地查信息！