脱氧半乳糖苷酶抑素盐酸盐
1-Deoxygalactonojirimycin Hydrochloride(1-Deoxygalactonojirimycin Hydrochloride)
CAS: 75172-81-5
化学式: C6H14ClNO4
| 中文名 | 1-Deoxygalactonojirimycin Hydrochloride |
| 英文名 | 1-Deoxygalactonojirimycin Hydrochloride |
| 别名 | 化合物 T12038 脱氧半乳糖苷酶抑素盐酸盐 脱氧半乳糖野生霉素 盐酸盐 1-脱氧半乳糖野尻霉素盐酸盐 1-DEOXYGALACTONOJIRIMYCIN(盐酸盐) |
| 英文别名 | DGJ GALACTOSTATIN HCL DGJ, HYDROCHLORIDE DEOXYGALACTONOJIRIMYCIN HCL 1-DEOXYGALACTONOJIRIMYCIN HCL DEOXYGALACTONOJIRIMYCIN, HYDROCHLORIDE 1-Deoxygalactonojirimycin Hydrochloride 1,5-DIDEOXY-1,5-IMINO-D-GALACTITOL, HYDROCHLORIDE 3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, hydrochloride, (2R,3S,4R,5S)- |
| CAS | 75172-81-5 |
| 化学式 | C6H14ClNO4 |
| 分子量 | 199.63 |
| 熔点 | 260 |
| 溶解度 | 甲醇 (微溶) 、水 (微溶) |
| 存储条件 | 2-8°C |
| 外观 | 白色结晶固体 |
| 颜色 | White to Brown |
| 体外研究 | Both IC 50 and K i values of Migalastat (GR181413A) hydrochloride toward human lysosomal a-Gal A are 0.04 μM. |
| 体内研究 | Fabry disease is an X-linked recessive disorder caused by the deficient activity of α-galactosidase A. α-Gal A activity in heart, kidney, spleen, and liver is increased dose- and time-dependently in transgenic mice that express human mutant alpha-Gal A with Migalastat (GR181413A) hydrochloride treatment. The half-life of DGJ is less than 1 day in all major issues and that of the enzyme synthesized during the DGJ treatment period is approximately 4 days. Oral administration of Migalastat (GR181413A) hydrochloride reduces tissue GL-3 in fabry transgenic mice, and in urine and kidneys of some FD patients. Oral administration of Migalastat (GR181413A) hydrochloride to transgenic mice reduces elevated lyso-Gb3 levels up to 64%, 59%, and 81% in kidney, heart, and skin, respectively, generally equal to or greater than observed for GL-3. |
| 危险品标志 | Xi - 刺激性物品 |
| 风险术语 | 36/37/38 - 刺激眼睛、呼吸系统和皮肤。 |
| 安全术语 | S26 - 不慎与眼睛接触后，请立即用大量清水冲洗并征求医生意见。 S36 - 穿戴适当的防护服。 |
| WGK Germany | 3 |
| 海关编号 | 29333990 |
| Hazard Note | Irritant |
脱氧半乳糖苷酶抑素盐酸盐 - 配置溶液浓度参考
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 5.009 ml | 25.046 ml | 50.093 ml |
| 5 mM | 1.002 ml | 5.009 ml | 10.019 ml |
| 10 mM | 0.501 ml | 2.505 ml | 5.009 ml |
| 5 mM | 0.1 ml | 0.501 ml | 1.002 ml |
最后更新：2024-01-02 23:10:35
供应商列表
现货供应
产品名: 1-脱氧半乳糖野尻霉素盐酸盐 去供应商网站查看 询盘CAS: 75172-81-5
产地: 中国上海
包装: 5mg
规格: 98%
价格: 848.00
库存: 现货
电话: 400-900-4166
手机: 18017137653
电子邮件: 3007523013@qq.com
QQ: 3007523013
微信: 18017137653
产品描述: 中文名：1-脱氧半乳糖野尻霉素盐酸盐 英文名:Migalastat hydrochloride CAS:75172-81-5 规格:98% 产地:中国上海
现货供应
产品名: Migalastat hydrochloride 去供应商网站查看 询盘CAS: 75172-81-5
产地: 上海
规格: M910358
价格: 10mg-1264
库存: 7天内发货
电话: 13816333479/17821173903
手机: 13816333479/17821173903
电子邮件: wangrui@macklin.cn
QQ: 2885703204/288570320
微信: 19863730987/17821173903
现货供应
产品名: 1-Deoxygalactonojirimycin Hydrochloride 去供应商网站查看 询盘CAS: 75172-81-5
产地: 上海
规格: 99%
价格: 1mg 500,5mg 1300,10mg 1950,25mg 3900
库存: 现货
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403
微信: 18301782025
产品描述: 1-Deoxygalactonojirimycin Hydrochloride 99% MedMol 货号：S86413
现货供应
产品名: 1-脱氧半乳糖野尻霉素盐酸盐 去供应商网站查看 询盘CAS: 75172-81-5
产地: 中国上海
包装: 5mg
规格: 98%
价格: 848.00
库存: 现货
电话: 400-900-4166
手机: 18017137653
电子邮件: 3007523013@qq.com
QQ: 3007523013
微信: 18017137653
产品描述: 中文名：1-脱氧半乳糖野尻霉素盐酸盐 英文名:Migalastat hydrochloride CAS:75172-81-5 规格:98% 产地:中国上海
现货供应
产品名: Migalastat hydrochloride 去供应商网站查看 询盘CAS: 75172-81-5
产地: 上海
规格: M910358
价格: 10mg-1264
库存: 7天内发货
电话: 13816333479/17821173903
手机: 13816333479/17821173903
电子邮件: wangrui@macklin.cn
QQ: 2885703204/288570320
微信: 19863730987/17821173903
现货供应
产品名: 1-Deoxygalactonojirimycin Hydrochloride 去供应商网站查看 询盘CAS: 75172-81-5
产地: 上海
规格: 99%
价格: 1mg 500,5mg 1300,10mg 1950,25mg 3900
库存: 现货
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403
微信: 18301782025
产品描述: 1-Deoxygalactonojirimycin Hydrochloride 99% MedMol 货号：S86413
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