脱氧鬼臼毒素
去氧鬼臼毒素,去氧鬼臼脂素(Deoxypodophyllotoxin)
CAS: 19186-35-7
化学式: C22H22O7
| 中文名 | 去氧鬼臼毒素,去氧鬼臼脂素 |
| 英文名 | Deoxypodophyllotoxin |
| 别名 | 脱氧鬼臼毒素 去氧鬼臼脂素 去氧鬼臼毒素对照品 去氧鬼臼毒素标准品 脱氧鬼臼毒素,脱氧鬼臼脂素 去氧鬼臼毒素,去氧鬼臼脂素 |
| 英文别名 | anthric Nsc403148 Deoxypodophyllotoxin Desoxypodophyllotoxin 4-Deoxypodophyllotoxin Podophyllotoxin 9-Desoxy Impurity Deoxypodophyllotoxin, deoxypodophyllotoxin |
| CAS | 19186-35-7 |
| 化学式 | C22H22O7 |
| 分子量 | 398.41 |
| 密度 | 1.304±0.06 g/cm3(Predicted) |
| 熔点 | 168 °C |
| 沸点 | 564.5±50.0 °C(Predicted) |
| 比旋光度 | -119 (CHCl3) |
| 溶解度 | 溶于甲醇，乙醚 |
| 存储条件 | 2-8℃ |
| 物化性质 | 无色棱柱状结晶(无水乙醇)，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于桃儿七Sinopodophyllum hexandrum (Royle) Ying；八角莲Dysosma versipellis (Hance) M. Cheng ex Ying的根茎。 |
| 体外研究 | Deoxypodophyllotoxin (25-75 nM; 6-48 hours) increases the percentage of early apoptotic cell population from 2.05 to 5.62 and 18.49% for 24 h and 48 h, respectively. Deoxypodophyllotoxin (25-75 nM; 6-48 hours) treats SGC-7901 cells arrested in G2/M phase in time- and dose- dependent manners. Deoxypodophyllotoxin (25-75 nM; 6-48 hours) results in a remarkably time- and dose-dependent decrease in Cdc2 and Cdc25C expression levels and increases cyclin B1 within 6h, decreases PARP, Bcl-2 and caspase-3 activity. Apoptosis Analysis Cell Line: SGC-7901 cells Concentration: 25, 50, 75 nM Incubation Time: 6, 12, 24, 48 hours Result: Induced apoptosis in SGC-7901 Cells. Cell Cycle Analysis Cell Line: SGC-7901 cells Concentration: 25, 50, 75 nM Incubation Time: 6, 12, 24, 48 hours Result: Induced G2/M cell cycle arrest in SGC-7901 Cells Western Blot Analysis Cell Line: SGC-7901 cells Concentration: 25, 50, 75 nM Incubation Time: 6, 12, 24, 48 hours Result: Altered the expression of cyclin B1, Cdc2,Cdc25C, p-PARP, Bcl-2 and p-caspase-3 proteins. |
| 体内研究 | Deoxypodophyllotoxin (intravenously injected; 5, 10, and 20 mg/kg; 3 times a week; 28 days) suppresses the tumors in a dose-dependent manner, the growth of tumors is inhibited by 22.19%, 47.91% and 50.93% with DPT at 5, 10 and 20 mg/kg, respectively. Animal Model: Xenograft model of gastric cancer in nude mice with SGC-7901 cells Dosage: 5, 10, and 20 mg/kg Administration: Intravenously injected; 5, 10, and 20 mg/kg; 3 times a week; 28 days Result: Inhibited the growth of gastric cancer tumors. |
| 参考资料 展开查看 | 1. 王林娜 胡培 杨光义. UPLC-MS/MS法同时测定6种鬼臼木脂素浓度及药动学研究[J]. 湖北医药学院学报 2017(05):411-417. |
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现货供应
产品名: 去氧鬼臼毒素,去氧鬼臼脂素 去供应商网站查看 询盘CAS: 19186-35-7
产地: 中国上海
包装: 5mg
规格: 分析对照品,HPLC≥96.0%
价格: 3328.00
库存: 现货
电话: 400-900-4166
手机: 18017137653
电子邮件: 3007523013@qq.com
QQ: 3007523013
微信: 18017137653
产品描述: 中文名：去氧鬼臼毒素,去氧鬼臼脂素 英文名:Deoxypodophyllotoxin CAS:19186-35-7 规格:分析对照品,HPLC≥96.0% 产地 更多
现货供应
产品名: 去氧鬼臼毒素,去氧鬼臼脂素 去供应商网站查看 询盘CAS: 19186-35-7
产地: 上海
规格: HPLC≥98%
价格: 5mg 2300
库存: 现货
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403
微信: 18301782025
产品描述: 去氧鬼臼毒素,去氧鬼臼脂素 HPLC≥98% 源叶 货号：B30307
现货供应
产品名: 去氧鬼臼毒素,去氧鬼臼脂素 去供应商网站查看 询盘CAS: 19186-35-7
产地: 中国上海
包装: 5mg
规格: 分析对照品,HPLC≥96.0%
价格: 3328.00
库存: 现货
电话: 400-900-4166
手机: 18017137653
电子邮件: 3007523013@qq.com
QQ: 3007523013
微信: 18017137653
产品描述: 中文名：去氧鬼臼毒素,去氧鬼臼脂素 英文名:Deoxypodophyllotoxin CAS:19186-35-7 规格:分析对照品,HPLC≥96.0% 产地 更多
现货供应
产品名: 去氧鬼臼毒素,去氧鬼臼脂素 去供应商网站查看 询盘CAS: 19186-35-7
产地: 上海
规格: HPLC≥98%
价格: 5mg 2300
库存: 现货
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403
微信: 18301782025
产品描述: 去氧鬼臼毒素,去氧鬼臼脂素 HPLC≥98% 源叶 货号：B30307
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