莫西沙星游离碱
莫西沙星(Moxifloxacin)
CAS: 151096-09-2
化学式: C21H24FN3O4
| 中文名 | 莫西沙星 |
| 英文名 | Moxifloxacin |
| 别名 | 莫西沙星 莫西沙星游离碱 莫西沙星EP杂质 盐酸莫西沙星MOXIFLOXACIN HYDROCHLORIDE 莫西沙星(母核)1-环丙基-6,7-二氟-1,4-二氢-8-甲氧基-4-氧代-3-喹啉羧酸 1-环丙基-7-(S,S-2,8-二氮杂双环[4.3.0]壬烷-8-基)-6-氟-8-甲氧-4-氧代-1,4-二氢-3-喹啉羧酸 (4ΑS-CIS)-1-环丙基-6-氟-1,4-二氢-8-甲氧基-7-(六氢-6H-吡咯[3,4-B] 吡啶-6-基)-4-氧-3-喹啉羧酸 (1S,6S)-1-环丙基-7-(S,S-2,8-二氮杂双环(4.3.0)壬烷-8-基)-6-氟-8-甲氧-4-氧代-1,4-二氢-3-喹啉羧酸 |
| 英文别名 | Avdox CS-83 Moxifloxacin MOXIFLOXACIN MAXIOFFOXACIN Moxifloxacin EP Impurity MOXIFLOXACIN HYDROCHELORIDE Moxifloxacin Hydrochloride 2 (1'S,6'S)-1-Cyclopropyl-7-(2,8-diazabicyclo[4.3.0]non-8-yl)-6-fluoro-8-methoxy-4-oxo-1,4-dihyd (1'S,6'S)-1-Cyclopropyl-7-(2,8-diazabicyclo[4.3.0]non-8-yl)-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (4αS-cis)-1-Cydopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(octahydro-6H-pyrrolo[3,4-b]pyridin-6-y1)-4-oxo-3-quinolinecarboxylic acid 1-cyclopropyl-6-fluoro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 7-[(4aS,7aS)-octahydro-1H-pyrrolo[3,4-b]pyridin-6-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid |
| CAS | 151096-09-2 |
| EINECS | 604-773-0 |
| 化学式 | C21H24FN3O4 |
| 分子量 | 401.43 |
| InChI | InChI=1/C21H24FN3O4/c1-29-20-17-13(19(26)14(21(27)28)9-25(17)12-4-5-12)7-15(22)18(20)24-8-11-3-2-6-23-16(11)10-24/h7,9,11-12,16,23H,2-6,8,10H2,1H3,(H,27,28)/t11-,16+/m0/s1 |
| 密度 | 1.408±0.06 g/cm3(Predicted) |
| 熔点 | 203-208 C |
| 沸点 | 636.4±55.0 °C(Predicted) |
| 比旋光度 | 23D -193° |
| 闪点 | 338.7°C |
| 蒸汽压 | 4.56E-17mmHg at 25°C |
| 溶解度 | 乙腈 (微溶)，DMSO (微溶，加热，超声处理)，甲醇 (微溶) |
| 折射率 | 1.633 |
| 酸度系数 | 6.43±0.50(Predicted) |
| 存储条件 | 2-8°C(protect from light) |
| 稳定性 | 吸湿性 |
| 外观 | 固体 |
| 颜色 | Off-White to Light Yellow |
| 体外研究 | The in vitro activities of Moxifloxacin and Amoxicillin are compared by time-kill curve and inhibition of intracellular growth experiments by using a model of bone marrow-derived mouse macrophages infected by L. monocytogenes EGDe. Moxifloxacin acts much more rapidly, beginning to exert its effects in the first 3 h and achieving complete broth sterilization within 24 h of incubation. Moxifloxacin appears to have a protective effect against macrophage lysis, as many cells are still viable after 24 h of incubation. |
| 危险品标志 | Xn - 有害物品 |
| 风险术语 | R22 - 吞食有害。 R40 - 少数报道有致癌后果。 |
| 安全术语 | 36/37 - 穿戴适当的防护服和手套。 |
| 上游原料 | 正辛烷 烟酸诺氟沙星 氮杂双环 氘代乙二醇 氢氧化钯 氟化钠 丙二酸二乙酯 氢氧化钾 醋酸 |
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