中文名 | 远志皂苷D |
英文名 | Polygalacin D |
别名 | 远志皂苷D 远志皂苷D2 |
英文别名 | Onjisaponin D Polygalacin D Polygalacin D2 Olean-12-en-28-oic acid, 3-(β-D-glucopyranosyloxy)-2,16,23-trihydroxy-, O-D-apio-β-D-furanosyl-(1→3)-O-β-D-xylopyranosyl-(1→4)-O-6-deoxy-α-L-mannopyranosyl-(1→2)-α-L-arabinopyranosyl ester, (2β,3β,4β,16α)- |
CAS | 66663-91-0 |
化学式 | C57H92O27 |
分子量 | 1209.34 |
密度 | 1.54±0.1 g/cm3 (20 ºC 760 Torr) |
熔点 | 221-226°C |
比旋光度 | -41.5 (c, 1 in MeOH) |
溶解度 | 可溶于水、乙醇、甲醇等溶剂,不溶于石油醚、氯仿、乙酸乙酯。 |
酸度系数 | 12.76±0.70(Predicted) |
存储条件 | 4℃冷藏、密封、避光 |
敏感性 | Easily absorbing moisture |
外观 | 白色针状晶体 |
MDL号 | MFCD28009141 |
体外研究 | Polygalacin D (0-40 µM; 48 hours) inhibits cell proliferation with IC 50 s of 26.49 µM in the A549 cells and 20.52 µM in the H460 cells. Polygalacin D (0-20 µM; 48 hours) increases the proportion of early and late apoptotic cells, and nuclear condensation is observed in A549 and H460 cells. Polygalacin D (0-20 µM; 48 hours) may exerts its apoptotic effects by regulating the apoptotic proteins and the IAP family of proteins in A549 and H460 cells. Cell Proliferation Assay Cell Line: A549 and H460 cancer cell lines Concentration: 10 µM, 20 µM, 40µM Incubation Time: 48 hours Result: Inhibited the proliferation of NSCLC cell lines. Apoptosis Analysis Cell Line: A549 and H460 cancer cell lines Concentration: 10 µM, 20 µM Incubation Time: 48 hours Result: Induced apoptosis of NSCLC cell lines. Western Blot Analysis Cell Line: A549 and H460 cancer cell lines Concentration: 10 µM, 20 µM Incubation Time: 48 hours Result: Decreased survivin, c-IAP-1 and c-IAP-2 expression. |
参考资料 展开查看 | 1. 张玲, 郭宣宣, 朱丽丽. 桔梗中苦味物质的分布与动态积累研究[J]. 中药新药与临床药理, 2019, 030(005):586-591. 2. [IF=3.205] Chi Zhang et al."Active microbial metabolites study on antitussive and expectorant effects and metabolic mechanisms of platycosides fraction of Platycodonis Radix."J Chromatogr B. 2022 Apr;1195:123171 |
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