醋酸格拉替雷
醋酸格拉替雷(glatiramer acetate)
CAS: 147245-92-9
化学式: C25H45N5O13
| 中文名 | 醋酸格拉替雷 |
| 英文名 | glatiramer acetate |
| 别名 | 格拉替美 醋酸格拉替雷 醋酸格卡替雷 格拉替雷-D7 醋酸格拉替雷 147245-92-9 L-丙氨酸-L-谷氨酸-L-赖氨酸-L-酪氨酸多肽聚合物醋酸盐 |
| 英文别名 | ProtiraMer glatiramer acetate GaltiraMer acetate GLATIRAMER ACETATE (2S)-2-aminopropanoic acid (2S)-2,6-diaminohexanoic acid (2S)-2-aminopentanedioic acid acetic acid, (2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid L-Alanine polyMer with L-GlutaMic Acid L-Lysine L-Tyrosine Acetate L-Tyrosine polyMer with L-Alanine L-GlutaMic Acid L-Lysine Acetate L-GlutaMic Acid peptide with L-Alanine L-Lysine L-Tyrosine Acetate Salt l-glutamic acid polymer with l-alanine, l-lysine and l-tyrosine, acetate (salt) |
| CAS | 147245-92-9 |
| EINECS | 814-981-5 |
| 化学式 | C25H45N5O13 |
| 分子量 | 623.66 |
| InChI | InChI=1/C9H11NO3.C6H14N2O2.C5H9NO4.C3H7NO2.C2H4O2/c10-8(9(12)13)5-6-1-3-7(11)4-2-6;7-4-2-1-3-5(8)6(9)10;6-3(5(9)10)1-2-4(7)8;1-2(4)3(5)6;1-2(3)4/h1-4,8,11H,5,10H2,(H,12,13);5H,1-4,7-8H2,(H,9,10);3H,1-2,6H2,(H,7,8)(H,9,10);2H,4H2,1H3,(H,5,6);1H3,(H,3,4)/t8-;5-;3-;2-;/m0000./s1 |
| 熔点 | >239°C (dec.) |
| 沸点 | 385.2°C at 760 mmHg |
| 闪点 | 186.7°C |
| 蒸汽压 | 1.27E-06mmHg at 25°C |
| 溶解度 | 甲醇 (微溶) 、水 (微溶) |
| 存储条件 | Refrigerator |
| 外观 | 固体 |
| 颜色 | White to Off-White |
| 体外研究 | Glatiramer acetate (25-100 mg/kg; S.c; 5 days) increase BDNF levels. In huntington’s disease (HD) mouse model, the N171-82Q transgenic mouse line, which exhibits a more rapidly progressing disease course. Glatiramer acetate (1 mg/mouse; s.c.; 5×week) beginning at 8 weeks of age and continuing until 20 weeks of age, which is near the age of death due to the disease. Glatiramer acetate elicited improves performance on several motor function measures. Glatiramer acetate significantly improves the performance of N171-82Q transgenic mice at 15 weeks of age in the rotarod test measured over the course of 4 days. |
| 上游原料 | L-赖氨酸 L-丙氨酸 |
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