里氟康唑_化工百科

中文名	Ravuconazole (BMS-207147 ER-30346)
英文名	4-[2-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1,2,4-triazol-1-yl)b utan-2-yl]-1,3-thiazol-4-yl]benzonitrile
别名	里氟康唑雷氟康唑立福康唑立福康唑,雷夫康唑 4-(2-((2R,3R)-3-(2,4-二氟苯基)-3-羟基-4-(1H-1,2,4-三唑-1-基)丁烷-2-基)噻唑-4-基)苯甲腈
英文别名	Er-30346 Bms-207147 ER-30346) Aids057176 Bms-207,147 Aids-057176 Ravuconazole (BMS-207147 4-[2-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1,2,4-triazol-1-yl)b utan-2-yl]-1,3-thiazol-4-yl]benzonitrile Benzonitrile, 4-[2-[(1R,2R)-2-(2,4-difluro-phenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]- [R-(R,R)]-4-{2-[2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)-propyl]-4-thiazolyl}-benzonitrile
CAS	182760-06-1
化学式	C22H17F2N5OS
分子量	437.47
密度	1.38±0.1 g/cm3(Predicted)
熔点	64-66°C
沸点	674.9±65.0 °C(Predicted)
比旋光度	D24 -29.1° (c = 1.03 in methanol)
酸度系数	11.62±0.29(Predicted)
存储条件	-20°C Freezer
体外研究	Ravuconazole shows a broad spectrum of activity against a wide range of fungi covering Candida spp. , Trichosporon beigelii , C. neoformans and A. fumigatus . The MIC 90 ranges from 0.025 to 0.39 mg/mL.Ravuconazoleshows relatively higher levels of activity against three strains of Candida krusei , with MICs ranging from 0.05 to 0.39 mg/mL.Ravuconazoleshows good activity against T. mentagrophytes , T. rubrum , M. gypseum and M. canis with MICs ranging from 0.05 to 0.39 mg/mL. Ravuconazoleis about two- to four fold more potent than itraconazole and about 40-fold more active than fluconazole against yeasts. Ravuconazoleand itraconazoleare inhibitory to most aspergilli, and against half of the isolates, the activity iscidal. Ravuconazoleand itraconazoleare active, though not cidal, against most hyaline Hyphomycetes , dermatophytes, and the dematiaceous fungi and inactive against Sporothrix schenckii and zygomycetes.
体内研究	The maximum concentration of ravuconazole in plasma and the area under the concentration-time curve for ravuconazoleshow good linearity over a range of doses from 2 to 40 mg/kg of body weight. Ravuconazole at a dose of 2.5 mg/kg delays mortality significantly compared with the control treatment.Ravuconazole also shows a substantial therapeutic effect against systemic cryptococcosis. Ravuconazole reduces the numbers of CFU in the lungs significantly compared with the numbers of CFU in the lungs of the controls. In an experimental model of oral candidiasis in rats, ravuconazole reduces the numbers of CFU in oral swabs significantly compared with the numbers of CFU in oral swabs from the controls and is more effective than itraconazole and as effective as fluconazole..
上游原料	艾沙康唑杂质9 2'-氯-2,4-二氟苯乙酮 861718-85-6 861718-83-4 对氰基苯乙酮

里氟康唑 - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	2.286 ml	11.429 ml	22.859 ml
5 mM	0.457 ml	2.286 ml	4.572 ml
10 mM	0.229 ml	1.143 ml	2.286 ml
5 mM	0.046 ml	0.229 ml	0.457 ml

最后更新：2024-01-02 23:10:35

北京索莱宝科技有限公司

产品名: 立福康唑去供应商网站查看询盘
CAS: 182760-06-1
产地: 北京
包装: 1mg /瓶
规格: IR2190-1mg
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现货供应

产品名: 雷夫康唑去供应商网站查看询盘
CAS: 182760-06-1
产地: 中国上海
包装: 2mg
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现货供应

产品名: Ravuconazole 去供应商网站查看询盘
CAS: 182760-06-1
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上海源叶生物科技有限公司

产品名: Ravuconazole (BMS-207147; ER-30346) 去供应商网站查看询盘
CAS: 182760-06-1
产地: 上海
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