阿基瑞林
阿基瑞林(Argireline)
CAS: 616204-22-9
化学式: C34H60N14O12S
| 中文名 | 阿基瑞林 |
| 英文名 | Argireline |
| 别名 | 阿基瑞琳 阿基瑞林 阿基瑞林原液 乙酰基六肽-8 美容肽-阿基瑞林 ARGIRELINEACETATE (ACETYLHEXAPEPTIDE-3) |
| 英文别名 | Reproage Argireline Anti-Wrinkle Multi-Peptides Ac-Glu-Glu-Met-Glu-Arg-Arg-NH2 Argireline,Acetyl hexapeptide-3, BR N-Acetyl-L-alpha-glutamyl-L-alpha-glutamyl-L-methionyl-L-glutaminyl-L-arginyl-L-argininamide Argireline acetate Ac-Glu-Glu-Met-Arg-Arg-NH2 |
| CAS | 616204-22-9 |
| EINECS | 1592732-453-0 |
| 化学式 | C34H60N14O12S |
| 分子量 | 889 |
| InChI | InChI=1/C34H60N14O12S/c1-17(49)43-20(8-11-25(51)52)29(57)47-22(9-12-26(53)54)31(59)48-23(13-16-61-2)32(60)46-21(7-10-24(35)50)30(58)45-19(6-4-15-42-34(39)40)28(56)44-18(27(36)55)5-3-14-41-33(37)38/h18-23H,3-16H2,1-2H3,(H2,35,50)(H2,36,55)(H,43,49)(H,44,56)(H,45,58)(H,46,60)(H,47,57)(H,48,59)(H,51,52)(H,53,54)(H4,37,38,41)(H4,39,40,42)/t18-,19-,20-,21-,22-,23-/m0/s1 |
| InChIKey | RJZNPROJTJSYLC-LLINQDLYSA-N |
| 密度 | 1.54 |
| 溶解度 | 水溶性 |
| 折射率 | 1.66 |
| 酸度系数 | 4.43±0.10(Predicted) |
| 存储条件 | -20°C |
| 外观 | 冻干固体 |
| 颜色 | white |
| 体外研究 | The incubation of Argireline solution in different concentrations with human embryonic kidney HEK-293 (IC 50 of 34.862 μM) and neuroblastoma IMR-32 cells (IC 50 of 68.458 μM)) for 48 h have dose dependent antiproliferative effect. Argireline solution incubated in different concentrations with HSF has a dose-dependent antiproliferative effect on those cells. Cellular proliferation is not effected in Argireline low concentration. |
| 体内研究 | Argireline is applied to the aged mice twice daily for 6 weeks. There is an improvement in the histological structure of skin tissue in the aged mice; the amount of type I collagen fibers increased, while that of type III collagen fibers decreased. Argireline could improve the histological structure of skin tissue and rejuvenate the aging skin. |
| WGK Germany | 2 |
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