中文名 | 阿替美唑盐酸盐 |
英文名 | 1H-Imidazole, 4-(2-ethyl-2,3-dihydro-1H-inden-2-yl)-, monohydrochloride |
别名 | 阿替美唑盐酸盐 阿替美唑盐酸盐(标准品) 4-(2-乙基-2-茚满)咪唑盐酸盐 化合物ATIPAMEZOLE HYDROCHLORIDE 4-(2-乙基-2,3-二氢-1H-茚-2-基)-1H-咪唑盐酸盐 |
英文别名 | Antisedan Atipamezole HCL MPV1248 hydrochloride MPV 1248 hydrochloride Atipamezole hydrochloride 4-(2-Ethyl-2-indanyl)imidazole hydrochloride 4-(2-Ethyl-2,3-dihydro-1H-inden-2-yl)-1H-imidazole hydrochloride 1H-Imidazole, 4-(2-ethyl-2,3-dihydro-1H-inden-2-yl)-, monohydrochloride |
CAS | 104075-48-1 |
EINECS | 105-700-9 |
化学式 | C14H16N2.HCl |
分子量 | 248.75 |
InChI | InChI=1/C14H16N2.ClH/c1-2-14(13-9-15-10-16-13)7-11-5-3-4-6-12(11)8-14;/h3-6,9-10H,2,7-8H2,1H3,(H,15,16);1H |
熔点 | 211-215° |
沸点 | 396°C at 760 mmHg |
闪点 | 193.3°C |
蒸汽压 | 1.17E-06mmHg at 25°C |
溶解度 | DMSO (微溶) 、甲醇 (微溶) |
存储条件 | Sealed in dry,Room Temperature |
外观 | 固体 |
颜色 | White to Off-White |
Merck | 14,861 |
体外研究 | The affinity of atipamezole for α 2 -adrenoceptors and its α 2 /α 1 selectivity ratio are considerably higher than yohimbine. Atipamezole is not selective for subtypes of α 2 -adrenoceptors. It has negligible affinity for 5-HT 1 , 5-HT2 and I2 bindings sites. |
体内研究 | Atipamezole is well tolerated in rodents. In anesthetized, normotensive rats, the cardiovascular effects of atipamezole (0.01–1 mg/kg, i.v.) are rather modest. Atipamezole is commonly used by veterinarians to awaken animals from sedation or anesthesia. Atipamezole increases sexual activity in rats and monkeys. In animals with sustained nociception, atipamezole increases pain-related responses by blocking the noradrenergic feedback inhibition of pain. Atipamezole at low doses has beneficial effects on alertness, selective attention, planning, learning, and recall in experimental animals, but not necessarily on short-term working memory. |
RTECS | NI6139000 |
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