中文名 | 阿莫兰特 |
英文名 | Almokalant |
别名 | 阿莫兰特 化合物 T14189 |
英文别名 | Almokalant Benzonitrile, 4-[3-[ethyl[3-(propylsulfinyl)propyl]amino]-2-hydroxypropoxy]- |
CAS | 123955-10-2 |
化学式 | C18H28N2O3S |
分子量 | 352.496 |
体外研究 | Almokalant is a class III antiarrhythmic drug, acts as a potassium channel blocker, and inhibits a specific component (Ikr) of the time-dependent delayed rectifier K + current. |
体内研究 | Almokalant (125 μmol/kg, p.o.) induces cardiovascular defects, orofacial clefts, and tail defects in pregnant rats, after administration on Day 11. Almokalant also causes in pregnant rats. |