隐绿原酸
隐绿原酸(Cryptochlorogenic acid)
CAS: 905-99-7
化学式: C16H18O9
| 中文名 | 隐绿原酸 |
| 英文名 | Cryptochlorogenic acid |
| 别名 | 隐绿原酸 4-咖啡奎宁酸 4-咖啡酰奎尼酸 4-咖啡因奎宁酸 隐绿原酸(标准品) 4-二咖啡酰奎宁酸 隐绿原酸(4-咖啡酰奎宁酸) CRYPTOCHLOROGENIC ACID 隐绿原酸 |
| 英文别名 | 4-Caffeoylquinic acid Cryptochlorogenic acid 4-Dicaffeoylquinic Acid Quinic acid 4-O-caffeate Quinic acid 4-O-caffeate Cryptochlorogenic acid(4') 4-Caffeoylquinic acidQuinic acid 4-O-caffeate 3,4-Dihydroxycinnamic acid 4-carboxy-2,4,6-trihydroxycyclohexyl ester 3,4-Dihydroxycinnamic acid 4-carboxy-2,4,6-trihydroxycyclohexyl ester |
| CAS | 905-99-7 |
| 化学式 | C16H18O9 |
| 分子量 | 354.31 |
| InChI | InChI=1/C16H18O9/c17-9-3-1-8(5-10(9)18)2-4-13(21)25-14-11(19)6-16(24,15(22)23)7-12(14)20/h1-5,11-12,14,17-20,24H,6-7H2,(H,22,23)/b4-2+/t11-,12-,14-,16+/m1/s1 |
| 密度 | 1.65 |
| 熔点 | 182-184°C |
| 沸点 | 694.9±55.0 °C(Predicted) |
| 比旋光度 | -75 (-54) (H2O) |
| 溶解度 | DMSO: 50毫克/毫升 (141.12毫米; 需要超声波) |
| 折射率 | 1.69 |
| 酸度系数 | 4.07±0.50(Predicted) |
| 存储条件 | 2-8°C |
| 敏感性 | Sensitive to light |
| 外观 | 整洁 |
| 物化性质 | 白色针状结晶，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于杜仲，忍冬，金银花。 |
| MDL号 | MFCD10566638 |
| WGK Germany | 3 |
| 参考资料 展开查看 | 1. 杨琴 包宜康 顾亚琴 等. HPLC法同时测定野马追药材中绿原酸、新绿原酸、隐绿原酸的含量[J]. 邵阳学院学报(自然科学版) 2018 v.15;No.60(02):94-98. 2. 王贞媛. 一测多评法测定瘪桃干药材中3个酚酸类成分[J]. 中国药品标准 2020 v.21(04):93-97. 3. 徐翔英 衷林清 彭琴 等. 主成分分析法考察不同采收期草珊瑚中7个化学成分的含量[J]. 中国药学杂志 2018 053(009):675-681. 4. 尹小英, 江一帆, 杨华生,等. 罗布麻定时脉冲片中5种酚酸及黄酮类成分的含量测定[J]. 中国药学杂志, 2011, 46(020):1605-1608. 5. 陈育鹏, 赵倩, 王贵金,等. 连花清瘟胶囊超高效液相指纹图谱研究[J]. 中国中医药信息杂志, 2017, 024(012):77-80. 6. 何悦 王四旺 肖会敏. HPLC法同时测定复方金银花颗粒中10种成分的含量[J]. 药学实践杂志 2019 037(002):177-182. 7. 高利利 王奕博 陈功森 等. 双黄连颗粒制备过程中金银花-连翘成分迁移研究[J]. 中南药学 2020 v.18;No.173(06):32-37. 8. 周游宇, 周莉莉, 乔勇,等. 山银花配方颗粒高效液相色谱特征指纹图谱研究[J]. 湖南中医杂志, 2019, v.35;No.243(05):153-155. 9. 杨敏, 时庆欣, 王玄源,等. 苦丁茶中绿原酸的水提工艺研究[J]. 湖北中医药大学学报, 2017(3). 10. 张莉 周娟娟. UPLC法同时测定银翘解毒合剂中10种成分[J]. 中成药 2018 40(08):86-89. 11. 林素英 谢文燕 何松涛 等. 不同品种枇杷果实酚类物质及其抗氧化活性分析[J]. 食品工业科技 2016 37(18):149-152. 12. 高利利 倪健 于颖超 等. 双黄连颗粒HPLC指纹图谱及化学模式识别分析[J]. 中国中医药信息杂志 2019 026(010):60-65. 13. 王春驰, 周婷婷, 纪圣君,等. 返魂草药材提取方法考察与特征图谱建立[J]. 长春中医药大学学报, 2019, 035(002):322-325. 14. 董婷, 周建良, 赵维良,等. 基于指纹图谱的银翘解毒颗粒质量评价[J]. 中国现代应用药学, 2018, 35(09):68-72. 15. 马云, 王尧尧, 王蕾,等. 忍冬花发育期间形态与13种活性成分含量变化[J]. 中药材, 2018, 041(007):1559-1565. 16. 梁从莲, 刘红燕, 崔媛,等. 金银花指纹图谱及其清除DPPH自由基的谱-效关系[J]. 中国实验方剂学杂志, 2015. 17. 王俊俊 张俐 郭青 等. 一测多评法测定8个银翘解毒系列制剂中的7种酚酸类成分的含量[J]. 药学学报 2015 050(004):480-485. 18. 刘倩 张敏敏 李圣波 等. HPLC-DAD法测定西藏产区金银花花蕾及叶中化学成分含量[J]. 山东科学 2018 031(004):20-25. 19. 王玲娜 刘红燕 张金 等. "一测多评法"与外标法测定金银花中8种活性成分含量[J]. 中国实验方剂学杂志 2014 20(20):57-61. 20. 路俊仙, 吕凌, 张才波. 忍冬4个药用部位中11种化学成分的含量测定[J]. 中药材, 2019(5). 21. 王玲娜, 刘红燕, 李佳,等. 忍冬叶有效成分含量与气候因子的灰色关联分析[J]. 山东农业科学, 2014(11):57-60. 22. 路俊仙, 吕凌, 张才波. 金银花和灰毡毛忍冬多成分定性的指纹图谱比较[J]. 中华中医药杂志, 2019, 034(007):3215-3219. 23. 苏征 王玲娜 张芳 等. 不同产地忍冬藤HPLC指纹图谱比较研究[J]. 时珍国医国药 2017(05):193-195. 24. 王玲娜,苏征,刘星劼,张芳,刘谦,张永清.金银花活性成分与生态因子相关性研究[J].中国实验方剂学杂志,2016,22(17):27-31. 25. 王玲娜,张芳,李佳,刘红燕,姜秋,张永清.金银花新品种“华金6号”药材品质比较研究[J].中药材,2019,42(09):2030-2035. 26. 潘馨 衷林清 周楚楚 等. HPLC同时测定草珊瑚中9个有效成分的含量[J]. 药物分析杂志 2017 037(007):1207-1214. 27. 张敏敏, 刘代成, 王岱杰,等. SPME-GC/MS联合HSDE-HPLC-DAD分析表征金银花新品种中的主要化学成分[J]. 天然产物研究与开发, 2016, 028(009):1390-1396,1413. 28. 王玲娜, 孙希芳, 张芳,等. 不同发育时期金银花颜色与活性成分的相关性分析[J]. 中草药, 2017, 15(v.48;No.602):171-177. 29. 覃柳莹,蔡梦如,姚宇,白杰,吴慧敏,张志勤,张硕峰,倪健,格桑顿珠,尹兴斌.藏药四臣止咳颗粒的指纹图谱研究[J].中南药学,2021,19(03):507-512. 30. 王贞媛.一测多评法测定瘪桃干药材中3个酚酸类成分[J].中国药品标准,2020,21(04):371-375. 31. 胡飞凤,黄文康.高效液相色谱波长切换技术对复方野菊感冒颗粒中8种成分的含量测定[J].中国新药与临床杂志,2020,39(10):618-622. 32. 金辉辉,钱正,姚建标,吴旦,刘永祥,付志文,王如伟.基于多成分测定及特征图谱评价不同批次肠炎宁片质量[J].药物分析杂志,2020,40(12):2174-2185. 33. 谭春梅,黄琴伟,王征南,马临科,赵维良.复方鱼腥草合剂特征图谱及基于Orbitrap超高分辨质谱结合多元数理统计方法的成分分析[J].药物分析杂志,2020,40(10):1770-1779. 34. 张恒,郑俏然,何靖柳,韦婷,刘翔,章斌.藏茶玫瑰乌梅无糖复合饮料研制及功能性成分分析与抗氧化研究[J].食品科技,2021,46(01):46-53+61. 35. Tao, Yi, et al. "Integrating UHPLC–MS/MS quantification and DAS analysis to investigate the effects of wine-processing on the tissue distributions of bioactive constituents of herbs in rats: Exemplarily shown for Dipsacus asper." Journal of Chromatography 36. Li, Moying, et al. "Method for rapidly discovering active components in Yupingfeng granules by UPLC‐ESI‐Q‐TOF‐MS." Journal of Mass Spectrometry 55.10 (2020): e4627.https://doi.org/10.1002/jms.4627 37. Chenxi Yang, Chenglin Song, Yitong Liu, Jiao Qu, Haibo Li, Wei Xiao, Lingdong Kong, Huiming Ge, Yang Sun, Wen Lv, Re-Du-Ning injection ameliorates LPS-induced lung injury through inhibiting neutrophil extracellular traps formation, Phytomedicine, Volume 90 38. Wang, Fang, et al. "Identification of the allergenic ingredients in reduning injection by ultrafiltration and high-performance liquid chromatography." Journal of immunology research 2016 (2016).https://doi.org/10.1155/2016/4895672 39. Valkó, Klára. "Application of high-performance liquid chromatography based measurements of lipophilicity to model biological distribution." Journal of chromatography A 1037.1-2 (2004): 299-310.https://doi.org/10.1016/j.chroma.2003.10.084 40. Valkó, Klára. "Application of high-performance liquid chromatography based measurements of lipophilicity to model biological distribution." Journal of chromatography A 1037.1-2 (2004): 299-310.https://doi.org/10.1016/j.chroma.2003.10.084 41. Cai, Z, Liao, H, Wang, C, et al. A comprehensive study of the aerial parts of Lonicera japonica Thunb. based on metabolite profiling coupled with PLS-DA. Phytochemical Analysis. 2020; 31: 786– 800. https://doi.org/10.1002/pca.2943 42. Cao, Yanni, et al. "Chemical fingerprint and multicomponent quantitative analysis for the quality evaluation of Cyclocarya paliurus leaves by HPLC–Q–TOF–MS." Molecules 22.11 (2017): 1927.https://doi.org/10.3390/molecules22111927 43. Xue, Gen, et al. "Integrating Study on Qualitative and Quantitative Characterization of the Major Constituents in Shuanghuanglian Injection with UHPLC/Q-Orbitrap-MS and UPLC-PDA." Journal of Analytical Methods in Chemistry 2021 (2021).https://doi.org/10.11 44. Zhengqi Pan, Qinfen Wu, Zhe Xie, Qiang Wu, Xinti Tan, Xin Wang,Upregulation of HSP72 attenuates tendon adhesion by regulating fibroblast proliferation and collagen production via blockade of the STAT3 signaling pathway,Cellular Signalling,Volume 71,2020,10 45. [IF=5.279] Yingying Wei et al."Hot Air Treatment Induces Disease Resistance through Activating the Phenylpropanoid Metabolism in Cherry Tomato Fruit."J Agr Food Chem. 2017;65(36):8003–8010 46. [IF=4.818] Wang Fang et al."Identification of the Allergenic Ingredients in Reduning Injection by Ultrafiltration and High-Performance Liquid Chromatography."J Immunol Res. 2016;2016:4895672 47. [IF=4.411] Jifeng Gu et al."Application of High-Performance Liquid Chromatography Coupled with Linear Ion Trap Quadrupole Orbitrap Mass Spectrometry for Qualitative and Quantitative Assessment of Shejin-Liyan Granule Supplements."Molecules. 2018 Apr;23(4):884 48. [IF=4.411] Ying Zhang et al."Compounds Identification in Semen Cuscutae by Ultra-High-Performance Liquid Chromatography (UPLCs) Coupled to Electrospray Ionization Mass Spectrometry."Molecules. 2018 May;23(5):1199 49. [IF=4.411] Yang Yang et al."The Prebiotic Activity of Simulated Gastric and Intestinal Digesta of Polysaccharides from the Hericium erinaceus."Molecules. 2018 Dec;23(12):3158 50. [IF=4.411] Yanni Cao et al."Chemical Fingerprint and Multicomponent Quantitative Analysis for the Quality Evaluation of Cyclocarya paliurus Leaves by HPLC–Q–TOF–MS."Molecules. 2017 Nov;22(11):1927 51. [IF=1.902] Yining Zhao et al."Simultaneous quantitation of 23 bioactive compounds in Tanreqing capsule by high-performance liquid chromatography electrospray ionization tandem mass spectrometry."Biomed Chromatogr. 2019 Jul;33(7):e4531 52. [IF=7.514] Yi Song et al."Caffeoyl substitution decreased the binding and inhibitory activity of quinic acid against α-amylase: The reason why chlorogenic acid is a relatively weak enzyme inhibitor."Food Chem. 2022 Mar;371:131278 53. [IF=6.529] Rui Guo et al."Uncovering the pharmacological mechanisms of Xijiao Dihuang decoction combined with Yinqiao powder in treating influenza viral pneumonia by an integrative pharmacology strategy."Biomed Pharmacother. 2021 Sep;141:111676 54. [IF=5.81] Mu Jianfei et al."Determination of Polyphenols in Ilex kudingcha and Insect Tea (Leaves Altered by Animals) by Ultra-high-performance Liquid Chromatography-Triple Quadrupole Mass Spectrometry (UHPLC-QqQ-MS) and Comparison of Their Anti-Aging Effects."Fro 55. [IF=5.34] Chenxi Yang et al."Re-Du-Ning injection ameliorates LPS-induced lung injury through inhibiting neutrophil extracellular traps formation."Phytomedicine. 2021 Sep;90:153635 56. [IF=5.246] Ji Xiuna et al."Protective Effect of Chlorogenic Acid and Its Analogues on Lead-Induced Developmental Neurotoxicity Through Modulating Oxidative Stress and Autophagy."Front Mol Biosci. 2021 Jun;0:440 57. [IF=5.165] Huan Zhang et al."Fermentation characteristics and the dynamic trend of chemical components during fermentation of Massa Medicata Fermentata."Arab J Chem. 2022 Jan;15:103472 58. [IF=4.952] Si Tan et al."The effects of drying methods on chemical profiles and antioxidant activities of two cultivars of Psidium guajava fruits."Lwt Food Sci Technol. 2020 Jan;118:108723 59. [IF=4.411] Min Li et al."Study of the Variation of Phenolic Acid and Flavonoid Content from Fresh Artemisiae argyi Folium to Moxa Wool."Molecules. 2019 Jan;24(24):4603 60. [IF=4.35] Chengcheng Zhang et al."Chemical Characterization and Antioxidant Properties of Ethanolic Extract and Its Fractions from Sweet Potato (Ipomoea batatas L.) Leaves."Foods. 2020 Jan;9(1):15 61. [IF=3.935] Hengqiang Zhao et al."An improved 2D-HPLC-UF-ESI-TOF/MS approach for enrichment and comprehensive characterization of minor neuraminidase inhibitors from Flos Lonicerae Japonicae."J Pharmaceut Biomed. 2019 Oct;175:112758 62. [IF=3.411] Shi Guiqin et al."UPLC-ESI-MS/MS Analysis and Evaluation of Antioxidant Activity of Total Flavonoid Extract from Paeonia lactiflora Seed Peel and Optimization by Response Surface Methodology (RSM)."Biomed Res Int. 2021;2021:7304107 63. [IF=3.373] Zhichen Cai et al."A comprehensive study of the aerial parts of Lonicera japonica Thunb. based on metabolite profiling coupled with PLS-DA."Phytochem Analysis. 2020 Nov;31(6):786-800 64. [IF=3.24] Zhichen Cai et al."Metabolomics characterizes the metabolic changes of Lonicerae Japonicae Flos under different salt stresses."Plos One. 2020 Dec;15(12):e0243111 65. [IF=2.633] Yanni Cao et al."Seasonal Variation in Phenolic Compounds and Antioxidant Activity in Leaves of Cyclocarya paliurus (Batal.) Iljinskaja."Forests. 2019 Aug;10(8):624 66. [IF=2.193] Xue Gen et al."Integrating Study on Qualitative and Quantitative Characterization of the Major Constituents in Shuanghuanglian Injection with UHPLC/Q-Orbitrap-MS and UPLC-PDA."J Anal Methods Chem. 2021;2021:9991363 67. [IF=1.902] Hongyan Liu et al."Spectrum–effect relationship study between HPLC fingerprints and antioxidant of honeysuckle extract."Biomed Chromatogr. 2019 Oct;33(10):e4583 68. [IF=1.813] Zhang Ying et al."Comparative Studies on Chemical Contents and Effect in Kidney-Yang Deficiency Rats of Salt-Processed Product and Wine-Processed Product of Cuscutae Semen."Evid-Based Compl Alt. 2019;2019:2049497 69. [IF=2.193] Wang Ziyan et al."Qualitative and Quantitative Evaluation of Chemical Constituents from Shuanghuanglian Injection Using Nuclear Magnetic Resonance Spectroscopy."J Anal Methods Chem. 2022;2022:7763207 70. [IF=4.411] Yi Li et al."Evaluation of Anti-Inflammatory and Antioxidant Effectsof Chrysanthemum Stem and Leaf Extract on Zebrafish Inflammatory Bowel Disease Model."Molecules. 2022 Jan;27(7):2114 71. [IF=7.514] Wenjing Liu et al."Quality structural annotation for the metabolites of chlorogenic acid in rat."Food Chem. 2022 Jan;:132134 72. [IF=7.514] Zeru Xu et al."Analysis of the binding selectivity and inhibiting mechanism of chlorogenic acid isomers and their interaction with grass carp endogenous lipase using multi-spectroscopic, inhibition kinetics and modeling methods."Food Chem. 2022 Jan;:13210 73. [IF=6.576] Yingchun Jin et al."Characteristics of Mulberry Leaf Powder Enriched With γ-Aminobutyric Acid and Its Antioxidant Capacity as a Potential Functional Food Ingredient."Frontiers in Nutrition. 2022; 9: 900718 74. [IF=3.645] Lewen Xiong et al."Study on phenolic acids of Lonicerae japonicae Flos based on ultrahigh performance liquid chromatography-tandem mass spectrometry combined with multivariate statistical analysis."JOURNAL OF SEPARATION SCIENCE |
隐绿原酸 - 简介
隐绿原酸是一种有机化合物。
性质：
- 外观为无色结晶或白色结晶粉末。
- 具有独特的苦味和酸味。
- 难溶于水，可溶于酒精、醚类等有机溶剂。
- 在碱性溶液中显示绿色荧光。
- 是一种比较稳定的有机酸。
用途：
- 隐绿原酸主要用于工业上的染料和颜料的生产。
- 它可以用作农药中的杀虫剂，对昆虫有较强的杀灭作用。
制法：
- 隐绿原酸的制备方法有多种，最常用的是从植物中提取，如蔓荆子、蓼科植物等。提取后经过结晶、过滤、干燥等工艺步骤得到纯净的隐绿原酸。
安全信息：
- 隐绿原酸具有较低的毒性，对人体和环境的影响较小。
- 在操作和储存过程中要注意避免吸入和接触。
- 在储存过程中应避免与氧化剂、强酸、强碱等物质接触，以防止发生危险反应。
性质：
- 外观为无色结晶或白色结晶粉末。
- 具有独特的苦味和酸味。
- 难溶于水，可溶于酒精、醚类等有机溶剂。
- 在碱性溶液中显示绿色荧光。
- 是一种比较稳定的有机酸。
用途：
- 隐绿原酸主要用于工业上的染料和颜料的生产。
- 它可以用作农药中的杀虫剂，对昆虫有较强的杀灭作用。
制法：
- 隐绿原酸的制备方法有多种，最常用的是从植物中提取，如蔓荆子、蓼科植物等。提取后经过结晶、过滤、干燥等工艺步骤得到纯净的隐绿原酸。
安全信息：
- 隐绿原酸具有较低的毒性，对人体和环境的影响较小。
- 在操作和储存过程中要注意避免吸入和接触。
- 在储存过程中应避免与氧化剂、强酸、强碱等物质接触，以防止发生危险反应。
最后更新：2024-04-09 15:16:53
供应商列表
提供多种规格现货供应
产品名: (1alpha,3R,4alpha,5R)-4-[[3-(3,4-二羟基苯基)-1-氧代-2-丙烯-1-基]氧基]-1,3,5-三羟基环己烷羧酸 去供应商网站查看 询盘CAS: 905-99-7
产地: 北京
包装: 瓶
规格: YS100379-25mg,YS100379-10mg
价格: 电话、微信、QQ、邮件
库存: 一周左右
电话: 010-50973130
手机: 17801761073(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 17801761073
产品描述: 索莱宝直销，欢迎来询
提供多种规格现货供应
产品名: (1alpha,3R,4alpha,5R)-4-[[3-(3,4-二羟基苯基)-1-氧代-2-丙烯-1-基]氧基]-1,3,5-三羟基环己烷羧酸 去供应商网站查看 询盘CAS: 905-99-7
产地: 北京
包装: 瓶
规格: YS100379-25mg,YS100379-10mg
价格: 电话、微信、QQ、邮件
库存: 一周左右
电话: 010-50973130
手机: 17801761073(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 17801761073
产品描述: 索莱宝直销，欢迎来询
您刚刚浏览过
你知道吗？
微信搜索化工百科或扫描下方二维码，添加化工百科小程序，随时随地查信息！