2-Methylimidazole
2-Methylimidazole
CAS: 693-98-1
Molecular Formula: C4H6N2
2-Methylimidazole - Names and Identifiers
| Name | 2-Methylimidazole |
| Synonyms | 2MZ 2MI 2MZ-H 2MZ-PW NSC 21394 Curezol 2MZ Actiron 2MI Epicure MI 2 Epikure MI 2 Curezol 2MZ-P IMicure AMI 2 Denka CN 25 Glyoxalethyline RESICURE(TM) 46 p-Oxal-methyline 2-methyl-imidazol AKOS BBS-00004447 2-Methylimidazole 2-Methylglyoxaline 2-methyl-imidazole 2-Methyl imidazole 2-methyl-1h-imidazol Imidazole, 2-methyl- 1H-2-MethyliMidazole 2-methyl-1H-imidazole 1H-Imidazole,2-methyl- 1H-Imidazole, 2-methyl- |
| CAS | 693-98-1 |
| EINECS | 211-765-7 |
| InChI | InChI=1/C4H6N2/c1-4-5-2-3-6-4/h2-3H,1H3,(H,5,6) |
| InChIKey | LXBGSDVWAMZHDD-UHFFFAOYSA-N |
2-Methylimidazole - Physico-chemical Properties
| Molecular Formula | C4H6N2 |
| Molar Mass | 82.1 |
| Density | 1.0500 (rough estimate) |
| Melting Point | 142-143 °C (lit.) |
| Boling Point | 267-268 °C (lit.) |
| Flash Point | 155 °C |
| Water Solubility | Soluble in water and ethanol. |
| Solubility | 780g/l |
| Vapor Presure | <1 mm Hg ( 0 °C) |
| Appearance | Solid |
| Color | White to light yellow |
| BRN | 1368 |
| pKa | 14.44±0.10(Predicted) |
| PH | 10.5-11.5 (100g/l, H2O, 20℃) |
| Storage Condition | 2-8°C |
| Sensitive | Sensitive to air |
| Refractive Index | 1.4970 (estimate) |
| MDL | MFCD00005190 |
| Physical and Chemical Properties | Trait solid. melting point 142~143 ℃ boiling point 267~268 ℃ solubility: soluble in water, ethanol, slightly soluble in cold benzene. |
| Use | It is used as an intermediate of drug metronidazole, and is also a curing agent for epoxy resin and other resins. |
2-Methylimidazole - Risk and Safety
| Hazard Symbols | C - Corrosive |
| Risk Codes | R22 - Harmful if swallowed R34 - Causes burns |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S25 - Avoid contact with eyes. |
| UN IDs | UN 3259 8/PG 2 |
| WGK Germany | 2 |
| RTECS | NI7175000 |
| TSCA | Yes |
| HS Code | 29332990 |
| Hazard Note | Harmful/Corrosive |
| Hazard Class | 8 |
| Packing Group | III |
| Toxicity | LD50 orally in Rabbit: 1500 mg/kg |
2-Methylimidazole - Upstream Downstream Industry
| Raw Materials | Ammonia Ethylenediamine Acetonitrile Acetonitrile Acetaldehyde |
| Downstream Products | 2-Methyl-5-nitroimidazole 2-Methyl-5-nitroimidazole-1-ethanol |
2-Methylimidazole - Reference
| Reference Show more | 1. [IF=7.46] Yang Hu et al."Ultrasensitive luteolin electrochemical sensor based on zeolitic imidazolate frameworks-derived cobalt trioxide @ nitrogen doped carbon nanotube/amino-functionalized graphene quantum dots composites modified glass carbon electrode."Sensor A 2. [IF=4.155] Siqi Zhang et al."Step-wise immobilization of multi-enzymes by zirconium-based coordination polymer in situ self-assembly and specific absorption."J Inorg Biochem. 2020 Jul;208:111093 3. [IF=3.361] Fahim A. Qaraah et al."Facile route for C–N/Nb2O5 nanonet synthesis based on 2-methylimidazole for visible-light driven photocatalytic degradation of Rhodamine B."Rsc Adv. 2019 Dec;9(68):39561-39571 |
2-Methylimidazole - Nature
Open Data Verified Data
needle-like crystals (benzene). Melting point 143-144 °c (136 °c). Boiling point 267 °c. Soluble in water, ethanol, slightly soluble in cold benzene.
Last Update：2024-01-02 23:10:35
2-Methylimidazole - Preparation Method
Open Data Verified Data
there are ethylenediamine method and glyoxal method.
- The ethylenediamine method is obtained by cyclization of ethylenediamine and acetonitrile in the presence of sulfur and then dehydrogenation under the catalysis of active nickel.
- glyoxal method
Last Update：2022-01-01 10:57:13
2-Methylimidazole - Introduction
It's hygroscopic. Easily soluble in water, pyridine and ethanol, slightly soluble in benzene, toxic to the skin, mucous membrane irritating and corrosive.
Last Update：2022-10-16 17:27:59
2-Methylimidazole - Use
Open Data Verified Data
The intermediate of metronidazole in the manufacture of drugs is also the curing agent of epoxy resin and other resins.
Last Update：2022-01-01 10:57:12
2-Methylimidazole - Safety
Open Data Verified Data
-
li is toxic and causes a sensitizing reaction to the skin, and its toxicity is similar to that of diamines. Mouse oral ld501400 mg/kg, intraperitoneal injection of LD50 480mg/kg. Operators should wear protective masks and rubber gloves.
- It is packed in iron or wooden barrels, lined with plastic bags, 30kg or 50kg per barrel. Store in a cool and ventilated place. Protection against heat, sun and moisture. According to the provisions of the storage and transportation of toxic chemicals.
Last Update：2022-01-01 10:57:13
2-Methylimidazole - Reference Information
| pH range of acid-base indicator discoloration | 10.5 |
| LogP | 0.22 at 25℃ |
| (IARC) carcinogen classification | 2B (Vol. 101) 2013 |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| trait | 2-methylimidazole is white or pale yellow granular or columnar. |
| Use | 2-methylimidazole is an intermediate of the drug metronidazole and the feed growth promoter dimethazole, it is also the curing agent of epoxy resin and other resins. As the medium-temperature curing agent for an epoxy resin, it can be used alone, but is mainly used as a curing accelerator for powder molding and powder coating. Hygroscopic, soluble in water, alcohol, difficult to dissolve in benzene. Irritant and corrosive to skin and mucous membranes. This product is used for the synthesis of metronidazole and diazole, and is also a curing agent for bad oxygen resin. It is used as the intermediate of drug metronidazole, and also the curing agent of epoxy resin and other resins. This product is the intermediate of drug metronidazole and feed growth promoter dimethazole, it is also the curing agent of epoxy resin and other resins. As the medium-temperature curing agent for an epoxy resin, it can be used alone, but is mainly used as a curing accelerator for powder molding and powder coating. It is an intermediate for the manufacture of drug metronidazole, and is also a curing agent for epoxy resins and other resins. Fiber fabric dye adjuvant. Organic Synthesis. used in the production of metronidazole, dinitroimidazole and other pharmaceutical intermediates; Can be used as curing agents such as epoxy resin, textile fiber dye adjuvant; additives used in the preparation of foam |
| Overview | 2-methylimidazole, also known as dimethylimidazole, is a white needle-like crystal or crystalline powder at room temperature. Relative molecular mass 82.11. The melting point was 145-146 °c. Boiling point 267 °c. Can sublimate. Flash point 160 °c. Insoluble in ether, cold benzene, soluble in water, Alcohols, Ketones. Irritation of the skin and mucous membranes. Mouse oral ld501400 mg/kg. 2-methylimidazole is an intermediate for the production of Trichomonas pesticide metronidazole. It is also the curing agent and curing accelerator of epoxy resin and other resins, which occupies a special position in the amine curing agent. As the intermediate temperature curing agent of epoxy resin, it can be used alone, after heat treatment in a short time, A cured product having a high heat distortion temperature can be obtained. However, it is mainly used as a curing accelerator for powder molding and powder coating. It can be obtained by dehydrogenation of 2-methylimidazoline. |
| preparation method | 1, using glyoxal, acetaldehyde and ammonia as raw materials, the crude 2-methylimidazole is formed after reaction, after sublimation and refining, the finished product can be obtained. 2, using ethylenediamine and acetonitrile as raw materials, the reaction was carried out in the presence of sulfur to form imidazoline, and then dehydrogenation was carried out at 200 ℃ in the presence of nickel catalyst, 2-methylimidazole can be prepared as a finished product. 3, with glyoxal and methylamine in the presence of formaldehyde reaction, can be obtained. |
| Process | is derived from the elimination and dehydrogenation of 2-methylimidazolines. The 2-methylimidazoline was heated to melt (m. P. 107 °c) and the active nickel was carefully added and the temperature was raised to 200-210 °c for 2H. The temperature is lowered to below 150 ° C., water is added to dissolve, hot pressure filtration is carried out to separate active nickel, the filtrate is concentrated to a temperature above 140 ° C., and discharge is cooled to obtain 2-methylimidazole. The product with purity more than 98% was produced by this method. The 1t product consumed 1095kg of ethylenediamine (95%) and 975kg of acetonitrile. A preferred method is to use glyoxal and aldehyde as starting materials. |
| production method | results from the elimination and dehydrogenation of 2-methylimidazolines. The 2-methylimidazoline was heated to melt (m. P. 107 °c) and the active nickel was carefully added and the temperature was raised to 200-210 °c for 2H. The temperature is lowered to below 150 ° C., water is added to dissolve, hot pressure filtration is carried out to separate active nickel, the filtrate is concentrated to a temperature above 140 ° C., and discharge is cooled to obtain 2-methylimidazole. The product with purity more than 98% was produced by this method. The 1t product consumed 1095kg of ethylenediamine (95%) and 975kg of acetonitrile. A preferred method is to use glyoxal and aldehyde as starting materials. |
| autoignition temperature | >600°C DIN 51794 |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 20:52:54
Supplier List
Featured Products
Product Name: 2-Methylimidazole Request for quotationCAS: 693-98-1
Tel: +86 025-57015632
Email: export@msnchem.com
Mobile: 18013328036
QQ: 2312053494
Featured ProductsMultiple SpecificationsSpot supply
Product Name: 2-Methylimidazole Request for quotationCAS: 693-98-1
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589
Wechat: +86 19849939632
Featured Products
Product Name: 2-Methylimidazole Request for quotationCAS: 693-98-1
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Spot supply
Product Name: 2-Methylimidazole Request for quotationCAS: 693-98-1
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3787852685
Spot supply
Product Name: 2-Methylimidazole Request for quotationCAS: 693-98-1
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Spot supply
Product Name: Ondansetron Impurity 6（Ondansetron EP Impurity F） Visit Supplier Webpage Request for quotationCAS: 693-98-1
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: 2-Methylimidazole Request for quotationCAS: 693-98-1
Tel: 15335994747
Email: 3521670276@qq.com
Mobile: 15335994747
QQ: 3521670276
Wechat: A2020071098
Product Name: 2-Methylimidazole Request for quotation
CAS: 693-98-1
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 693-98-1
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Multiple SpecificationsSpot supply
Product Name: 2-Methylimidazole Visit Supplier Webpage Request for quotationCAS: 693-98-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: 2-Methylimidazole Request for quotation
CAS: 693-98-1
Tel: 0086-13605431940
Email: xuli678323@126.com
Mobile: +86-13605431940
QQ: 56860987
Wechat: 13605431940
WhatsApp: 13605431940
CAS: 693-98-1
Tel: 0086-13605431940
Email: xuli678323@126.com
Mobile: +86-13605431940
QQ: 56860987
Wechat: 13605431940
WhatsApp: 13605431940
Featured Products
Product Name: 2-Methylimidazole Request for quotationCAS: 693-98-1
Tel: +86 025-57015632
Email: export@msnchem.com
Mobile: 18013328036
QQ: 2312053494
Featured ProductsMultiple SpecificationsSpot supply
Product Name: 2-Methylimidazole Request for quotationCAS: 693-98-1
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589
Wechat: +86 19849939632
Featured Products
Product Name: 2-Methylimidazole Request for quotationCAS: 693-98-1
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Spot supply
Product Name: 2-Methylimidazole Request for quotationCAS: 693-98-1
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3787852685
Spot supply
Product Name: 2-Methylimidazole Request for quotationCAS: 693-98-1
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Spot supply
Product Name: Ondansetron Impurity 6（Ondansetron EP Impurity F） Visit Supplier Webpage Request for quotationCAS: 693-98-1
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: 2-Methylimidazole Request for quotationCAS: 693-98-1
Tel: 15335994747
Email: 3521670276@qq.com
Mobile: 15335994747
QQ: 3521670276
Wechat: A2020071098
Product Name: 2-Methylimidazole Request for quotation
CAS: 693-98-1
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 693-98-1
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Multiple SpecificationsSpot supply
Product Name: 2-Methylimidazole Visit Supplier Webpage Request for quotationCAS: 693-98-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: 2-Methylimidazole Request for quotation
CAS: 693-98-1
Tel: 0086-13605431940
Email: xuli678323@126.com
Mobile: +86-13605431940
QQ: 56860987
Wechat: 13605431940
WhatsApp: 13605431940
CAS: 693-98-1
Tel: 0086-13605431940
Email: xuli678323@126.com
Mobile: +86-13605431940
QQ: 56860987
Wechat: 13605431940
WhatsApp: 13605431940
View History
Raw Materials for 2-Methylimidazole
Downstream Products for 2-Methylimidazole