Molecular Formula | C24H30O5 |
Molar Mass | 398.49 |
Density | 1.254±0.06 g/cm3(Predicted) |
Boling Point | 572.1±50.0 °C(Predicted) |
pKa | 4.76±0.10(Predicted) |
Physical and Chemical Properties | Chemical Properties Beraprost Sodium: C24H29NaO5. White hygroscopic powder, odorless. Easily soluble in methanol, soluble in ethanol or water, more soluble in isopropanol, almost insoluble in ether. |
Use | Purposes: for chronic arterial occlusive disease ulcers, pain and cold feeling. |
alcohol (I) is oxidized and dehydrogenated with dimethyl sulfoxide-dicyclohexylcarbodiimide (DCC) in anhydrous benzene and pyridine to obtain aldehyde (II); Then, under the protection of argon, the solution of phosphine (III) and sodium hydride in ethylene glycol dimethyl ether is immediately added to obtain compound (IV) with 80% yield. (Ⅳ) Reduced with lithium aluminum hydride to obtain 44% compound (V), and finally hydrolyzed to obtain beraprost.