260415-63-2
PD173955
CAS: 260415-63-2
Molecular Formula: C21H16Cl2N4OS
260415-63-2 - Names and Identifiers
260415-63-2 - Physico-chemical Properties
| Molecular Formula | C21H16Cl2N4OS |
| Molar Mass | 443.35 |
| Density | 1.49 |
| Solubility | DMSO: ≥ 32 mg/mL |
| Appearance | White powder. |
| Storage Condition | -20℃ |
| In vitro study | PD173955 potently inhibited Bcr-Abl-dependent cell growth with an IC50 of 2-35 nM in Bcr-Abl-positive cell lines, 100 to 200 times more sensitive than Bcr-Abl-negative cell lines. PD173955 also inhibits Kit ligand-dependent M07e cell proliferation with an IC50 of 40 nM by inhibiting Kit ligand-dependent c-kit autophosphorylation. In addition, PD173955, as a Src inhibitor, effectively inhibits mitotic progression during early mitosis of various cell types and induces different degrees of apoptosis. |
260415-63-2 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.256 ml | 11.278 ml | 22.556 ml |
| 5 mM | 0.451 ml | 2.256 ml | 4.511 ml |
| 10 mM | 0.226 ml | 1.128 ml | 2.256 ml |
| 5 mM | 0.045 ml | 0.226 ml | 0.451 ml |
Last Update：2024-01-02 23:10:35
260415-63-2 - Reference Information
| biological activity | PD173955 is a potent Bcr-Abl inhibitor with IC50 of 1-2 nM, which can also inhibit Src activity, the IC50 was 22 nM. PD173955 is a potent Bcr-Abl inhibitor with an IC50 of 1-2 nM and also inhibits Src activity with an IC50 of 22 nM. |
| Target | Value |
| Bcr-Abl () | 1 nM-2 nM |
| Src () | 22 nM |
Last Update：2024-04-09 02:00:14
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Product Name: PD173955 Visit Supplier Webpage Request for quotationCAS: 260415-63-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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