山柰酚-3-O-芸香糖苷
Kaempferol-3-O-rutinoside
CAS: 17650-84-9
Molecular Formula: C27H30O15
山柰酚-3-O-芸香糖苷 - Names and Identifiers
山柰酚-3-O-芸香糖苷 - Physico-chemical Properties
| Molecular Formula | C27H30O15 |
| Molar Mass | 594.52 |
| Density | 1.76 |
| Melting Point | 200°C (dec.) |
| Boling Point | 941.7±65.0 °C(Predicted) |
| Specific Rotation(α) | -52 (c, 1 in Py) |
| Solubility | Soluble in hot methanol, DMSO and other solvents. |
| Appearance | Yellow powder |
| Color | Off-White to Yellow |
| pKa | 6.20±0.40(Predicted) |
| Storage Condition | Inert atmosphere,Store in freezer, under -20°C |
| MDL | MFCD03427292 |
| Physical and Chemical Properties | Light yellow needle-like crystal, soluble in methanol, ethanol, DMSO and other organic solvents, derived from sophora rice, safflower. |
| In vitro study | For primarily cultured neurons suffered 2 h hypoxia followed by 24 h reoxygenation, nicotiflorin significantly attenuates cell death and reduces LDH release. Morphological observation also directly confirms its protective effect on neuron. After total 4 h hypoxia and 12 h reoxygenation, eNOS activity, mRNA and protein levels in the primarily cultured rat cerebral blood vessel endothelial cells treated with nicotiflorin (25-100 g/mL) 2 h after onset of hypoxia are significantly higher than eNOS activity, mRNA and protein levels in the pure H-R cells and also higher than eNOS activity, mRNA and protein levels in cells cultured under normoxic conditions. |
| In vivo study | At doses of 2.5, 5 and 10 mg/kg, nicotiflorin administered immediately after the onset of ischemia markedly reduces brain infarct volume and neurological deficits. Nicotiflorin (2.5-10 mg/kg) administered after onset of ischemia markedly reduces brain infarct volume by 24.5-63.2% and neurological deficits. |
山柰酚-3-O-芸香糖苷 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | S22 - Do not breathe dust. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29389090 |
山柰酚-3-O-芸香糖苷 - Reference
| Reference Show more | 1. Sun Chonglu, Wu haolou, Tianling et al. Analysis of the chemical constituents of the aerial parts of Trifolium pratense by UPLC-Q-TOF-MS method [J]. Chinese patent medicine 2018 040(006):1424-1429. 2. Guo, Yan. Content determination and cluster analysis of eight components in Zoca Wood granules [J]. China pharmacist, 2020, v.23(05):61-64. 3. Zhou Fei, Hu Rong, Liu Chenjie, et al. Comparison of pancreatic lipase activity inhibited by different processed products of forsythia suspensa leaves [J]. Journal of Shanxi University (Natural Science Edition), 2018, v.41;No.160(02):161-167. 4. JIA Tian JIA Tian Tian Tian man et al. Determination of plasma concentration of nicotinoside in rats by LC-MS/MS and its pharmacokinetics and bioavailability [J]. Modern Chinese medicine, 2019, 21(12):1625-1629. 5. Huang and Jun, Cui Xiaobing, Yang Junhui. Determination of three flavonoids in Sophora japonica L. By one-Test multi-evaluation method [J]. Anhui Medical University, 2019, 23(12):2366-2370. 6. Zhang yujiong, Peng Xin, Ji Qingyong, Guo Qiaosheng. Cluster analysis and principal component analysis on HPLC fingerprint of chloroform fraction of radix xanthii [J]. Chinese patent medicine, 2016,38(03):607-612. 7. Ren Li, Jia Tianyu, Li xinghuan, etc. Study on the quality standard of the medicinal materials of yellow flower oil point grass [J]. China Pharmacy, 2019, 030(008):1083-1090. 8. Yao Xin, Zhu Yan Rong, Huang Hongliang, Zeng Yanru, Yu Weiwu. Variation of medicinal active ingredients and screening of superior germplasm in raspberry [J]. Chinese Journal of Traditional Chinese Medicine, 2021,46(03):575-581. 9. Jia Tianyu, Guo Tianyuan, Tian Man, Zhi Sicheng, Yang Qing, Sun Jing. LC-MS/MS determination of the distribution of fireworks glycosides in rats and excreta [J]. Pharmacology and Clinic of traditional Chinese medicine, 2020,36(06):69-76. 10. Jiang Mengdan, Xia pengguo, Liang zonlock, Xu Xinhan, Chen Xiliang, Han Rylan. Study on the feasibility of using fibrous root of trifoliate based on microstructure, antioxidant activity and chemical composition [J]. Shi Zhen, National Medicine, 2020,31(10):2492-2495. 11. Yang, Jing, et al. "Determination of active compounds in raspberry leaf extracts and the effects of extract takes on mice." Food Science and Technology 40 (2019): 124-131.https:// doi.org/10.1590/fst.35518 12. Yang, Jing, et al. "Comparisons of the active components in four unripe raspberry extracts and their activities." Food Science and Technology 39 (2019): 632-639.https://doi.org/10.1590/fst.27418 13. [IF=5.396] Jiachan Zhang et al."Understanding the role of extracts from sea buckthorn seed residues in anti-melanogenesis properties on B16F10 melanoma cells."Food Funct. 2018 Oct;9(10):5402-5416 14. [IF=4.098] Chunlin Li et al."Rapid and non-destructive discrimination of special-grade flat green tea using Near-infrared spectroscopy."Spectrochim Acta A. 2019 Jan;206:254 15. [IF=7.514] Mingchun Wen et al."Identification of 4-O-p-coumaroylquinic acid as astringent compound of Keemun black tea by efficient integrated approaches of mass spectrometry, turbidity analysis and sensory evaluation."Food Chem. 2022 Jan;368:130803 16. [IF=7.514] Chu-Yang Wang et al."Isolation of wheat mutants with higher grain phenolics to enhance anti-oxidant potential."Food Chem. 2020 Jan;303:125363 17. [IF=5.165] Weizhuo Tang et al."Ultrasound-assisted extraction of four groups of Osmanthus fragrans fruit: Optimization, UPLC-Orbitrap-MS/MS characterization and anti-inflammatory activity evaluation."Arab J Chem. 2021 Apr;14:103086 18. [IF=4.952] Yuxin Hao et al."Stability and mechanism of phenolic compounds from raspberry extract under in vitro gastrointestinal digestion."Lwt Food Sci Technol. 2021 Mar;139:110552 19. [IF=4.24] Nana Li et al."Characterization of phenolic compounds and anti-acetylcholinase activity of coconut shells."Food Biosci. 2021 Aug;42:101204 20. [IF=4.098] Chunlin Li et al."Discrimination of white teas produced from fresh leaves with different maturity by near-infrared spectroscopy."Spectrochim Acta A. 2020 Feb;227:117697 21. [IF=2.431] Su Shang et al."Diversity of red, green and black cultivars of Chinese Toon [Toona sinensis (A. Juss.) Roem]: anthocyanins, flavonols and antioxidant activity."J Food Meas Charact. 2020 Dec;14(6):3206-3215 22. [IF=6.057] Qi Tong et al.Biosynthesis-based spatial metabolome of Salvia miltiorrhiza Bunge by combining metabolomics approaches with mass spectrometry-imaging.Talanta. 2021 Nov;:123045 23. [IF=5.682] Yanyi Xiao et al.Fisetin inhibits the proliferation migration and invasion of pancreatic cancer by targeting PI3K/AKT/mTOR signaling.Aging-Us. 2021 Nov 30; 13(22): 24753-24767 24. [IF=3.935] Junmao Li et al."Comprehensive chemical profiling of the flowers of Citrus aurantium L. var. amara Engl. and uncovering the active ingredients of lipid lowering."J Pharmaceut Biomed. 2022 Mar;211:114621 25. [IF=6.576] Junkun Pan et al."Inhibition of Dipeptidyl Peptidase-4 by Flavonoids: Structure-Activity Relationship, Kinetics and Interaction Mechanism."Frontiers in Nutrition. 2022; 9: 892426 26. [IF=4.24] Jun Li et al."In vitro xanthine oxidase inhibitory properties of Flos Sophorae Immaturus and potential mechanisms."Food Biosci. 2022 Jun;47:101711 |
山柰酚-3-O-芸香糖苷 - Reference Information
| biological activity | Kaempferol-3-O-rutinoside (nicotiporin, Nikotoflorin, Kaempferol 3-O-β-rutinoside) is a flavonoid extracted from Carthamus tintorius, it can change the shape and structure of injured neurons, reduce apoptotic cells, down-regulate the expression of p-JAK2, p-STAT3, caspase-3 and Bax, reduce Bax immunoreactivity, and increase Bcl-2 protein expression and immunoreactivity. |
| Target | Value |
| Use | kaempferol-3-o-rutin has the effects of lowering blood lipid, promoting blood circulation and removing blood stasis. for content determination/identification/pharmacological experiments. Pharmacological Efficacy: hypolipidemic, good dementia symptoms and memory protection |
Last Update：2024-04-09 20:52:54
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