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(+)-Evodiamine

Evodiamine

CAS: 518-17-2

Molecular Formula: C19H17N3O

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(+)-Evodiamine - Names and Identifiers

Name Evodiamine
Synonyms Evodiamine
Evodiaminel
d-Evodiamine
(+)-Evodiamine
Evodiamine, (+)-
Evodia rutaecarpa E.P.
EvodiaMine(IsoevodiaMine)
8,13,13b,14-tetrahydro-14-methyl-,(S)-
CAS 518-17-2
EINECS 637-111-4
InChI InChI=1/C19H17N3O/c1-21-16-9-5-3-7-14(16)19(23)22-11-10-13-12-6-2-4-8-15(12)20-17(13)18(21)22/h2-9,18,20H,10-11H2,1H3/t18-/m0/s1
InChIKey TXDUTHBFYKGSAH-UHFFFAOYSA-N

(+)-Evodiamine - Physico-chemical Properties

Molecular FormulaC19H17N3O
Molar Mass303.36
Density1.1684 (rough estimate)
Melting Point278°
Boling Point444.29°C (rough estimate)
Specific Rotation(α)D15 +352° (acetone); D +440° (chloroform)
Flash Point301.6°C
Solubility Soluble in acetone, slightly soluble in ethanol, ether, chloroform, almost insoluble in water, petroleum ether, benzene
Vapor Presure3.15E-13mmHg at 25°C
AppearanceWhite needle crystal (chloroform)
ColorYellow
pKa17.27±0.20(Predicted)
Storage ConditionSealed in dry,Store in freezer, under -20°C
StabilityStable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
SensitiveSensitive to light
Refractive Index1.5900 (estimate)
MDLMFCD06407824
Physical and Chemical PropertiesSoluble in acetone, slightly soluble in ethanol, ether, chloroform, almost insoluble in water, petroleum ether, benzene. Evodia rutaecarpa (Juss.) Benth, a rutaceae plant. The near-mature fruit.

(+)-Evodiamine - Risk and Safety

Hazard SymbolsT - Toxic
Toxic
Risk Codes25 - Toxic if swallowed
Safety Description45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDsUN 2811 6.1/PG 3
WGK Germany3
HS Code29339900

(+)-Evodiamine - Reference

Reference
Show more
1. Zhang Wei, Yilin, Shuxian, Houhua et al. Effects of total alkaloids from Evodia on left ventricular hypertrophy and calcineurin signaling pathway in rats [J]. Journal of Zunyi Medical College, 2014, 37(002):151-155.
2. Gu, Jia, Yu, Dan, Dan, Rui-Guang. Interaction between evodiamine and Liposome biomembrane: FTIR and DSC studies [J]. Spectroscopy and spectral analysis 2019 39(006):1757-1762.
3. Cao Zhi, Yang Yilin, Wang suiwen et al. Effect of evodiamine on proliferation and apoptosis of human glioma U251 cells [J]. Journal of Clinical Neurosurgery 2014.
4. Zhang Hong, Mei Li, Guo, Song long, et al. Pharmacognostical identification of fructus evodiae and its pseudo-product on the fruit of aromatic and hot trees [J]. Chinese herbal medicine 2016 (phase 3):515-518.
5. Zhang Hongmei, Li Guo, Song long, et al. Fingerprint analysis and content determination of fructus evodiae from Guizhou and Zhejiang [J]. Chinese Journal of Experimental prescriptions, 2014, 20(017):69-73.
6. Liu Lu, Wang Xuemei, Wang Yan, Xi Hongmei, Guo jiando, Huang Qiujin. Promoting Effect of evodiamine on apoptosis of glioma SHG-44 cells and its mechanism [J]. Journal of Chinese Academy of Medical Sciences, 2020,42(05):591-595.
7. Xu Guobo, Lei Dandan, Xiao Yaohua, Chen Guanggui, He Xun, Liao Shanggao. Study on characteristic fingerprint of liangjiangweiyang capsule by HPLC [J]. Central South pharmacy, 2020,18(09):1503-1507.
8. Zhou Jianxin, Shen Shuo, du maobo, Li Yujie, Sun Yi, He Aiping, Yao Yao, Wang Mingsuo, Liu Shuzhi, Yin Yongqin. Based on UPLC-Q-TOF-MS technology and integrated pharmacological methods to explore the molecular mechanism of the transdermal components of Evodia and its treatment of Diarrhea [J]. Chinese Journal of Experimental prescriptions, 2021,27(07):112-120.
9. Chen Yongshun, Yang Jinxia, Wu Zhen. Preparation and quality evaluation of evodiamine hydrogel patch [J]. China pharmacist, 2021,24(03):571-574.
10. Zhang Y, Wang J, Wang C, Li Z, Liu X, Zhang J, Lu J, Wang D. Pharmacological Basis for the Use of Evodiamine in Alzheimer's Disease: Antioxidation and Antiapoptosis. International Journal of Molecular Sciences. 2018; 19(5):1527. https://doi.org/10.3390/ijm
11. [IF=4.183] Yongfeng Zhang et al."Pharmacological Basis for the Use of Evodiamine in Alzheimer's Disease: Antioxidation and Antiapoptosis."Int J Mol Sci. 2018 May;19(5):1527
12. [IF=4.432] Zhijun Zhao et al."Identification of evodiamine and rutecarpine as novel TMEM16A inhibitors and their inhibitory effects on peristalsis in isolated Guinea-pig ileum."Eur J Pharmacol. 2021 Oct;908:174340
13. [IF=2.952] Yongfeng Zhang et al."Protection against ulcerative colitis and colorectal cancer by evodiamine via anti‑inflammatory effects."Mol Med Rep. 2022 May;25(5):1-14
14. [IF=4.05] Xingming Hou et al."Evodiamine Lowers Blood Lipids by Up-Regulating the PPARγ/ABCG1 Pathway in High-Fat-Diet-Fed Mice."J Nat Prod. 2021;XXXX(XXX):XXX-XXX

(+)-Evodiamine - Introduction

Pharmacological effects: evodiamine has the effects of invigorating the stomach, analgesia, stopping retching and stopping acid; it has a diuretic effect; it has a strong inhibitory effect on E. coli; it has a significant insecticidal effect on Ascaris suis; it also contracts the uterus And the effect of pressure. It is effective in treating Alzheimer's disease and stroke.
Last Update：2022-10-16 17:25:47
(+)-Evodiamine
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Nantong Reform Petro-Chemical CO., LTD.
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CAS: 518-17-2
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Shanghai Yuanye Bio-Technology Co., Ltd.
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CAS: 518-17-2
Tel: 18301782025
Email: 3008007409@qq.com
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Zouping Mingxing Chemical Co., Ltd.
Product Name: Evodiamine  Request for quotation
CAS: 518-17-2
Tel: 0086-13605431940
Email: xuli678323@126.com
Mobile: +86-13605431940
QQ: 56860987 Click to send a QQ message
Wechat: 13605431940
WhatsApp: 13605431940
Nantong Reform Petro-Chemical CO., LTD.
Spot supply
Product Name: Evodiamine Request for quotation
CAS: 518-17-2
Tel: +86-17551318830
Email: r@reformchem.com­
Mobile: +86-17551318830
QQ: 3785839865 Click to send a QQ messageSend QQ message
Jiangsu Pules Biotechnology Co.,Ltd.
Product Name: Evodiamine Request for quotation
CAS: 518-17-2
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: Evodiamine Request for quotation
CAS: 518-17-2
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Yuanye Bio-Technology Co., Ltd.
Multiple SpecificationsSpot supply
Product Name: Evodiamine Visit Supplier Webpage Request for quotation
CAS: 518-17-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Zouping Mingxing Chemical Co., Ltd.
Product Name: Evodiamine  Request for quotation
CAS: 518-17-2
Tel: 0086-13605431940
Email: xuli678323@126.com
Mobile: +86-13605431940
QQ: 56860987 Click to send a QQ message
Wechat: 13605431940
WhatsApp: 13605431940
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(+)-Evodiamine
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