(+)-corynoline
corynoline
CAS: 18797-79-0
Molecular Formula: C21H21NO5
(+)-corynoline - Names and Identifiers
| Name | corynoline |
| Synonyms | corynoline CORYNOLINE CORYNOLINE(P) (+)-corynoline 13-methylchelidonine dimethyl-, (5bR,6S,12bR)- 13-Methylchelidonan-11β-ol [1,3]Benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridin-6-ol,5b,6,7,12b,13,14-hexahydro-5b,13- (5bR)-5bα,13-Dimethyl-5bα,6,7,12bα,13,14-hexahydro[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridine-6β-ol [1,3]Benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridin-6-ol, 5b,6,7,12b,13,14-hexahydro-5b,13-dimethyl-, (5bR,6S,12bR)- |
| CAS | 18797-79-0 |
| InChI | InChI=1/C21H21NO5/c1-21-14-3-4-15-19(27-10-24-15)13(14)8-22(2)20(21)12-7-17-16(25-9-26-17)5-11(12)6-18(21)23/h3-5,7,18,20,23H,6,8-10H2,1-2H3/t18-,20+,21-/m0/s1 |
(+)-corynoline - Physico-chemical Properties
| Molecular Formula | C21H21NO5 |
| Molar Mass | 367.4 |
| Density | 1.395±0.06 g/cm3(Predicted) |
| Melting Point | 180～181℃ |
| Boling Point | 504.2±50.0 °C(Predicted) |
| Specific Rotation(α) | +132 (c, 2.64 in CHCl3) (+116.4) |
| Flash Point | 258.7°C |
| Solubility | DMSO : 41.67 mg/mL (113.42 mM; Need ultrasonic) |
| Vapor Presure | 5.48E-11mmHg at 25°C |
| Appearance | Colorless granular crystal |
| Color | Off-White to Pale Yellow |
| pKa | 14.14±0.40(Predicted) |
| Storage Condition | Amber Vial, -20°C Freezer, Under inert atmosphere |
| Stability | Light Sensitive |
| Refractive Index | 1.659 |
| MDL | MFCD11042250 |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Kudi Ding. |
(+)-corynoline - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| HS Code | 29389090 |
(+)-corynoline - Reference Information
| biological activity | Corynoline, which can be separated from Corydalis incise (Papaveraceae), is a reversible and non Competitive acetylcholinesterase (AChE) inhibitor, IC50 is 30.6 μM. Corynoline exert anti-inflammatory effect by activating Nrf2. |
| chemical properties | white crystalline powder, soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from Kudi Ding. |
| use | corydalis has sedative and anti-leptospira effects. used for content determination/identification/pharmacological experiments and other pharmacological effects: inhibition of acetylcholinesterase |
Last Update：2024-04-09 20:49:11
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