(-)-儿茶素没食子酸酯
Catechin gallate
CAS: 130405-40-2
Molecular Formula: C22H18O10
(-)-儿茶素没食子酸酯 - Names and Identifiers
(-)-儿茶素没食子酸酯 - Physico-chemical Properties
| Molecular Formula | C22H18O10 |
| Molar Mass | 442.37 |
| Density | 1.80±0.1 g/cm3(Predicted) |
| Melting Point | 248-251 °C (decomp) |
| Boling Point | 861.7±65.0 °C(Predicted) |
| Solubility | Soluble in methanol |
| Appearance | White powder |
| Color | Pale Yellow to Light Red |
| pKa | 7.75±0.25(Predicted) |
| Storage Condition | 2-8°C |
| MDL | MFCD00214258 |
| Physical and Chemical Properties | White powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from green tea. |
| In vitro study | (-)-Catechin gallate (CG) directly interacts with DNA oligomers and inhibits the activity of COX-1 and COX-2 enzymes, the gene expression of matrix metalloproteinase-9 in macrophage-differentiated HL-60 myeloid leukemia cells, the adipocyte uptake of glucose by the transporter, GLUT4, and the activities of various proteasomes, i.e., the multicatalytic proteases responsible for the degradation of most cellular proteins. The relative cytotoxicities of a 3-day exposure to (-)-Catechin gallate are determined for cancerous CAL27 and HSG cells, immortalized epithelioid S-G cells, and normal HGF-1 gingival fibroblasts. The concentration at which toxicity (P≤0.01) initially occur is 25 μM (-)-Catechin gallate for S-G cells, 50 μM (-)-Catechin gallate for CAL27 cells, 62.5 μM (-)-Catechin gallate for HSG cells and 75 μM (-)-Catechin gallate for HGF-1 fibroblasts. The calculated neutral red (NR 50 ) values for a 3-day exposure to (-)-Catechin gallate are 58 μM for S-G cells, 62 μM for CAL27 cells, 90 μM for HSG cells and 132 μM for HGF-1 fibroblasts. |
(-)-儿茶素没食子酸酯 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| HS Code | 29329990 |
(-)-儿茶素没食子酸酯 - Reference Information
| Plant Source: | tea |
| biological activity | (-)-Catechin gallate is a minor component of green tea catechins. (-)-Catechin gallate inhibits COX-1 and COX-2 activity. |
| Use | catechin gallate has anti-inflammatory, analgesic and sedative effects. |
Last Update：2024-04-09 21:01:54
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