(-)-1-(3-hydroxyphenyl)-2-methylaminoethanol
(-)-Phenylephrine Base
CAS: 59-42-7
Molecular Formula: C9H13NO2
(-)-1-(3-hydroxyphenyl)-2-methylaminoethanol - Names and Identifiers
| Name | (-)-Phenylephrine Base |
| Synonyms | Phenylephrine L -PHENYLEPHRINE (-)-Phenylephrine Base (-)-1-(3-hydroxyphenyl)-2-methylaminoethanol (2R)-2-hydroxy-2-(3-hydroxyphenyl)-N-methylethanaminium chloride |
| CAS | 59-42-7 |
| EINECS | 200-424-8 |
| InChI | InChI=1/C9H13NO2.ClH/c1-10-6-9(12)7-3-2-4-8(11)5-7;/h2-5,9-12H,6H2,1H3;1H/t9-;/m0./s1 |
(-)-1-(3-hydroxyphenyl)-2-methylaminoethanol - Physico-chemical Properties
| Molecular Formula | C9H13NO2 |
| Molar Mass | 167.21 |
| Density | 1.1222 (rough estimate) |
| Melting Point | 171°C |
| Boling Point | 341.1°C at 760 mmHg |
| Flash Point | 163.4°C |
| Vapor Presure | 3.18E-05mmHg at 25°C |
| Storage Condition | 2-8℃ |
| MDL | MFCD00044749 |
| Physical and Chemical Properties | Bioactive (R)-(-)-Phenylephrine are selective α1-adrenoceptor agonists, mainly used as decongestants. |
| Use | Adrenaline-like drugs for surgery to extend the time of local anesthesia, nasal congestion, acute hypotension, infection and anaphylactic shock and other symptoms |
(-)-1-(3-hydroxyphenyl)-2-methylaminoethanol - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R41 - Risk of serious damage to eyes R37/38 - Irritating to respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S39 - Wear eye / face protection. |
(-)-1-(3-hydroxyphenyl)-2-methylaminoethanol - Upstream Downstream Industry
(-)-1-(3-hydroxyphenyl)-2-methylaminoethanol - Nature
Open Data Verified Data
This product is white or white crystalline powder, odorless, bitter; Contact with the air or sunlight, easy to Oxidative deterioration. This product is very slightly soluble in water, insoluble in ethanol, chloroform, ether, fatty oil or volatile oil; Soluble in mineral acid or sodium hydroxide solution, insoluble in ammonia solution or sodium carbonate solution. Epinephrine is mainly found in adrenal medullary chromaffin cells and is the main hormone of adrenal medulla. Medicinal products are extracted from the adrenal medulla of domestic animals or synthesized artificially. It is a, B receptor agonist, the and B receptors are very strong, so the effect is more complex and extensive. Due to the excitation of the pl receptor in the heart, the myocardial contractility is enhanced, the heart rate is accelerated, and the oxygen consumption of the myocardium is increased. The stimulation of a receptor can make the skin mucous membrane blood vessels and splanchnic blood vessels contract, while the coronary artery and skeletal muscle blood vessels are relaxed due to the stimulation of p2 receptor of vascular smooth muscle. Vasoconstrictor effect on the brain and lung is weak, sometimes due to increased blood pressure and passive expansion. Due to the excitation of bronchial smooth muscle p2 receptor and produce obvious expansion effect, especially when bronchospasm (such as bronchial asthma) is more obvious. Can be excited on the bronchial mucosa vascular smooth muscle a receptor, so that mucosal vasoconstriction, eliminate asthma mucosal edema, and improve ventilation. It has a significant effect on the metabolism of the body, can promote the decomposition of glycogen in the liver and skeletal muscle, increase the concentration of free fatty acids in the blood, increase the oxygen consumption of the body, and increase the body temperature.
Last Update：2024-01-02 23:10:35
(-)-1-(3-hydroxyphenyl)-2-methylaminoethanol - Preparation Method
Open Data Verified Data
- extraction, isolation and purification of adrenal medulla from domestic animals.
- Artificial synthesis.
Last Update：2022-01-01 11:16:36
(-)-1-(3-hydroxyphenyl)-2-methylaminoethanol - Use
Open Data Verified Data
adrenergic receptor agonists. It is used to relieve bronchial asthma, rescue anaphylactic shock, compatibility with local anesthetics and local hemostasis, urticaria, hay fever, serum reaction and other allergic diseases, glaucoma and so on.
Last Update：2022-01-01 11:16:36
(-)-1-(3-hydroxyphenyl)-2-methylaminoethanol - Safety
Open Data Verified Data
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Notable for pallor, restlessness, palpitation and Head Pain. Hypertension arteriosclerosis, hyperthyroidism, diabetes, narrow angle glaucoma patients are not used.
- store under reduced pressure, seal and store in a cool place.
Last Update：2022-01-01 11:16:37
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CAS: 59-42-7
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Product Name: Phenylephrine Visit Supplier Webpage Request for quotation
CAS: 59-42-7
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Email: 3008007409@qq.com
Mobile: 18021002903
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Wechat: 18301782025
CAS: 59-42-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History
Raw Materials for (-)-1-(3-hydroxyphenyl)-2-methylaminoethanol
(±)-3-hydroxy-alpha-[(methylamino)methyl]benzyl alcohol
L -PHENYLEPHRINE
Benzenemethanol, 3-methoxy-α-[(methylamino)methyl]-, (αR)-
3-Methoxybenzaldehyde
1-(3-Hydroxyphenyl)-2-(methylamino)ethanone hydrochloride
L -PHENYLEPHRINE
Benzenemethanol, 3-methoxy-α-[(methylamino)methyl]-, (αR)-
3-Methoxybenzaldehyde
1-(3-Hydroxyphenyl)-2-(methylamino)ethanone hydrochloride
Downstream Products for (-)-1-(3-hydroxyphenyl)-2-methylaminoethanol