Molecular Formula | C14H15N3O2 |
Molar Mass | 257.29 |
Density | 1.36±0.1 g/cm3(Predicted) |
Melting Point | 209-210° |
Boling Point | 420.8±37.0 °C(Predicted) |
Specific Rotation(α) | D25 -214° (c = 2 in methanol) |
pKa | 16.65±0.30(Predicted) |
Storage Condition | Room Temprature |
In vitro study | Indolmycin was bacteriostatic and demonstrated good activity against MSSA (methicillinsusceptible Staphylococcus aureus), MRSA (methicillin-resistant S. aureus) and VISA (vancomycinintermediate S. aureus), including strains resistant to mupirocin or fusidic acid. Indolmycin MICs for 20 strains ranged from 8 to 32 mg/L, whereas a single strain exhibited high-level resistance (MIC 128 mg/L). |
biological activity | Indolmycin (TAK-083) is an antibiotic that is a prokaryotic tryptophan-tRNA ligase (TrpS) competitive inhibitors. Indolmycin (TAK-083) has antibacterial and antiviral activity. |