(-)-Lotusine
Lotusine
CAS: 6871-67-6
Molecular Formula: C19H24NO3+
(-)-Lotusine - Names and Identifiers
| Name | Lotusine |
| Synonyms | Lotusine (-)-Lotusine D-(-)-Lotusine (1R)-1,2,3,4-Tetrahydro-6-hydroxy-1-[(4-hydroxyphenyl)methyl]-7-methoxy-2,2-dimethylisoquinolinium |
| CAS | 6871-67-6 |
(-)-Lotusine - Physico-chemical Properties
| Molecular Formula | C19H24NO3+ |
| Molar Mass | 314.4 |
| Solubility | Soluble in organic solvents such as methanol, ethanol, DMSO, etc, |
| Appearance | White crystal |
| Storage Condition | 2-8℃ |
| Physical and Chemical Properties | White crystal, soluble in methanol, ethanol, DMSO and other organic solvents, comes from lotus seed Nelumbo nucifera. |
(-)-Lotusine - Reference
| Reference Show more | 1. [IF=7.514] YueTong Yu et al."Identification and Quantification of Oligomeric Proanthocyanidins, Alkaloids, and Flavonoids in Lotus Seeds: A Potentially Rich Source of Bioactive Compounds."Food Chem. 2022 Jan;:132124 |
(-)-Lotusine - Reference Information
| Use | Liexin quaternary ammonium base is also called lotusine base, chemical name: 1-dimethyl-6-hydroxy-7-methoxy-10-benzyl (p-hydroxy) tetrahydroisoquinoline. In vitro and in vivo pharmacological experiments have proved that liensin quaternary ammonium base may be phosphodiesterase III and/or V type inhibitors. The substance has obvious positive inotropic effect and is better than the western medicine amrinone and papaverine. |
| extraction method | select clean and dry 8kg of lotus seed heart, soak wet with an appropriate amount of 3% Na2CO3 (about 100ml/kg of raw medicine) in advance, then add an appropriate amount (about 4000ml/kg) of methanol (or ethanol) and soak at room temperature for one week for three consecutive times. Merge methanol soaking solution, recover methanol, adjust pH to 2-3 with 1% hydrochloric acid for residual solution, filter, degrease filtrate with ether, continue the following steps: (1) separation of water-soluble total alkaloids, adjust pH to about 9 with concentrated ammonia water, extract 3 times each with chloroform, and recover chloroform. The water layer is filtered, the filtrate is adjusted to pH to 2-3 with hydrochloric acid, saturated reichellite is added, a large amount of precipitate is generated immediately, and the precipitate is collected. After air-drying at room temperature, dissolve in acetone, filter out insoluble matter, recover acetone in appropriate amount, After concentration, add saturated silver sulfate to make it fully precipitate, filter out the precipitate, the filtrate is a sulfate solution of water-soluble total alkali, (or after the filtrate is concentrated under appropriate pressure, add saturated barium chloride to immediately generate a large amount, after sufficient precipitation, the insoluble matter is filtered out), the filtrate is concentrated to syrup under reduced pressure, and crystallized to obtain 8.3g of crude crystal. (2) separation of lotus seed quaternary ammonium alkali by step crystallization 8.3g of crude product crystal was dissolved in 200ml of absolute ethanol (or methanol) and 50ml of water in hot water bath under reflux respectively, and repeated crystallization was carried out to obtain 6.2g of water-soluble total alkaloid crystal. Then it is crystallized step by step in anhydrous ethanol, and the first step is crystallized to obtain needle-like crystals to filter and separate the mother liquor; the mother liquor is crystallized in the second step to obtain a white square crystal 5.6, which is identified as lotus core quaternary ammonium base by TLC, and then It is repeatedly crystallized in methanol and water (depending on the color, it can be decolorized with activated carbon) to obtain 4.7g of fine lotus core quaternary ammonium base. |
| biological activity | Lotusine is a pure alkaloid extracted from the green seed embryo of the Nelumbo nucifera Gaertn. Lotusine has effect on action potential in myocardium and slow inward current of cardiac Purkinje fibers. |
| chemical properties | white crystal, soluble in methanol, ethanol, DMSO and other organic solvents, derived from lotus seed Nelumbo nucifera. |
Last Update：2024-04-09 15:16:39
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