(1-chloro-2-methylpropan-2-yl)(dimethyl)silane
tert-Butyldimethylsilyl chloride
CAS: 18162-48-6
Molecular Formula: C6H15ClSi
(1-chloro-2-methylpropan-2-yl)(dimethyl)silane - Names and Identifiers
(1-chloro-2-methylpropan-2-yl)(dimethyl)silane - Physico-chemical Properties
| Molecular Formula | C6H15ClSi |
| Molar Mass | 150.72 |
| Density | 0.87g/mLat 20°C(lit.) |
| Melting Point | 86-89 °C (lit.) |
| Boling Point | 125 °C (lit.) |
| Flash Point | 73°F |
| Water Solubility | Soluble in chloroform and ethyl acetate. Insoluble in water. |
| Solubility | very sol nearly all common organic solvents such asTHF, methylene chloride, and DMF. |
| Vapor Presure | 60-710Pa at 25℃ |
| Appearance | White powder |
| Specific Gravity | 1.225 |
| Color | white |
| Exposure Limit | ACGIH: TWA 20 ppmOSHA: Ceiling 300 ppm; TWA 200 ppmNIOSH: IDLH 500 ppm; TWA 100 ppm(375 mg/m3); STEL 150 ppm(560 mg/m3) |
| BRN | 505999 |
| Storage Condition | Store below +30°C. |
| Sensitive | Moisture Sensitive |
| Refractive Index | n20/D 1.46 |
| MDL | MFCD00000501 |
| Physical and Chemical Properties | Density 0.81 melting point 85-91°C boiling point 125°C flash point 22°C |
| Use | Used as pharmaceutical intermediates and for organic synthesis, as a hydroxyl protective agent in organic synthesis |
(1-chloro-2-methylpropan-2-yl)(dimethyl)silane - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R35 - Causes severe burns R40 - Limited evidence of a carcinogenic effect R34 - Causes burns R10 - Flammable R19 - May form explosive peroxides R11 - Highly Flammable R67 - Vapors may cause drowsiness and dizziness R65 - Harmful: May cause lung damage if swallowed R63 - Possible risk of harm to the unborn child R48/20 - R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R45 - May cause cancer R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R37 - Irritating to the respiratory system R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S46 - If swallowed, seek medical advice immediately and show this container or label. S62 - If swallowed, do not induce vomitting; seek medical advice immediately and show this container or label. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S25 - Avoid contact with eyes. S16 - Keep away from sources of ignition. S28 - After contact with skin, wash immediately with plenty of soap-suds. S27 - Take off immediately all contaminated clothing. S33 - Take precautionary measures against static discharges. S29 - Do not empty into drains. S53 - Avoid exposure - obtain special instructions before use. S36/37 - Wear suitable protective clothing and gloves. |
| UN IDs | UN 2925 4.1/PG 2 |
| WGK Germany | 2 |
| RTECS | VV2000000 |
| FLUKA BRAND F CODES | 10-21 |
| TSCA | Yes |
| HS Code | 29310095 |
| Hazard Note | Flammable/Corrosive/Moisture Sensitive |
| Hazard Class | 4.1 |
| Packing Group | III |
(1-chloro-2-methylpropan-2-yl)(dimethyl)silane - Reference Information
Open Data Unverified Data
| LogP | 2.5 at 20℃ |
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| use | auxiliary raw materials for the synthesis of prostaglandins, certain antibiotics, hypolipidemic drugs lovastatin and simvastatin used as pharmaceutical intermediates and Used in organic synthesis, as a hydroxyl protective agent in organic synthesis used in drug intermediates and organic synthesis, is a sterically hindered silicone protective agent, widely used in the synthesis of original drugs. It is used as a protective group for the hydroxyl group in the synthesis of ribonucleosides, and is also an oxidant and decyanating agent. silanizer. As a hydroxyl protective agent in organic synthesis, derivatization reagents are used for analysis and preparation. Protect tertiary alcohols. Reacts with alcohols to form silicone ether. Determination of the conformation of cholesterol derivatives. Synthesis of prostaglandins, auxiliary raw materials for certain antibiotics, lipid-lowering drugs Lofostine (Lovastatin) and Neofostine (Simvastatin). |
| Production method | The pentane solution of dichlorodimethylsilane is cooled to 0°C, and the pentane solution of tert-butyl lithium is added dropwise under nitrogen and stirring. Maintain 0 ℃, stir for 1.5h, then raise the temperature to 25 ℃, and continue the reaction for 48h. Distillate, collect 125 ℃(97.5kPa) fraction, stand and solidify to obtain tert-butyl dimethylchlorosilane. The yield is 70%. |
Last Update：2024-04-09 19:43:38
(1-chloro-2-methylpropan-2-yl)(dimethyl)silane - Introduction
Sensitive to humidity. Flammable. It's corrosive. Reacts with water, dissolves in ethers and hydrocarbons, and reacts with alcohols, organic acids and amines.
Last Update：2022-10-16 17:14:31
Supplier List
Spot supply
Product Name: tert-Butyldimethylsilyl chloride Request for quotationCAS: 18162-48-6
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3787852685
Spot supply
Product Name: tert-Butyldimethylsilyl chloride Request for quotationCAS: 18162-48-6
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Multiple Specifications
Product Name: tert-Butyldimethylsilyl chloride Request for quotationCAS: 18162-48-6
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589
Wechat: +86 19849939632
Product Name: tert-Butyldimethylsilyl chloride Request for quotation
CAS: 18162-48-6
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
CAS: 18162-48-6
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Spot supply
Product Name: tert-Butyldimethylsilyl chloride Request for quotationCAS: 18162-48-6
Tel: 15335994747
Email: 3521670276@qq.com
Mobile: 15335994747
QQ: 3521670276
Wechat: A2020071098
Product Name: tert-Butyldimethylsilyl chloride Request for quotation
CAS: 18162-48-6
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 18162-48-6
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Product Name: tert-Butyldimethylsilyl chloride Visit Supplier Webpage Request for quotation
CAS: 18162-48-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 18162-48-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: tert-Butyldimethylsilyl chloride Request for quotationCAS: 18162-48-6
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3787852685
Spot supply
Product Name: tert-Butyldimethylsilyl chloride Request for quotationCAS: 18162-48-6
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Multiple Specifications
Product Name: tert-Butyldimethylsilyl chloride Request for quotationCAS: 18162-48-6
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589
Wechat: +86 19849939632
Product Name: tert-Butyldimethylsilyl chloride Request for quotation
CAS: 18162-48-6
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
CAS: 18162-48-6
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Spot supply
Product Name: tert-Butyldimethylsilyl chloride Request for quotationCAS: 18162-48-6
Tel: 15335994747
Email: 3521670276@qq.com
Mobile: 15335994747
QQ: 3521670276
Wechat: A2020071098
Product Name: tert-Butyldimethylsilyl chloride Request for quotation
CAS: 18162-48-6
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 18162-48-6
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Product Name: tert-Butyldimethylsilyl chloride Visit Supplier Webpage Request for quotation
CAS: 18162-48-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 18162-48-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History