(10α,24R)-3β,11α,24,25-Tetrahydroxy-9β-methyl-19-norlanosta-5-ene
Mogrol
CAS: 88930-15-8
Molecular Formula: C30H52O4
(10α,24R)-3β,11α,24,25-Tetrahydroxy-9β-methyl-19-norlanosta-5-ene - Names and Identifiers
(10α,24R)-3β,11α,24,25-Tetrahydroxy-9β-methyl-19-norlanosta-5-ene - Physico-chemical Properties
| Molecular Formula | C30H52O4 |
| Molar Mass | 476.73 |
| Density | 1.10±0.1 g/cm3(Predicted) |
| Boling Point | 595.6±50.0 °C(Predicted) |
| Solubility | Soluble in methanol, ethanol, DMSO and other organic solvents |
| Appearance | White-like powder |
| pKa | 14.67±0.29(Predicted) |
| Storage Condition | -20℃ |
| Physical and Chemical Properties | White-like powder, soluble in methanol, ethanol, DMSO and other organic solvents, from Siraitia grosvenoris. |
| In vitro study | Mogrol (0-250 µM) significantly and dose- and time-dependently inhibits K562 cell growth and increases the number of apoptotic cells. Mogrol (0, 10, 100, and 250 µM) induces G1 phase cell cycle arrest in K562 cells. Treatment with mogrol significantly decreases ERK phosphorylation as compared to control cells, whereas total ERK protein is not affected. Mogrol dose-dependently induces growth arrest in G0/G1 phase of the cell cycle. Mogrol significantly and dose-dependently enhances p21 protein expression in K562 cells. Mogrol significantly represses the increase in cellular TG levels induced by differentiation stimuli, and suppresses TG accumulation at micromolar levels, with a statistically significant suppression observed above 10 μM. Mogrol suppresses adipogenesis in 3T3-L1 cells at concentrations that does not affect cell viability. Mogrol suppresses adipogenesis through at least two different mechanisms, increasing AMPK phosphorylation and repressing the activation of CREB. |
(10α,24R)-3β,11α,24,25-Tetrahydroxy-9β-methyl-19-norlanosta-5-ene - Reference
| Reference Show more | 1. Huang Bijing, Wang Lin, Li Sai, Sheng Li, Wang Haixia, Yang Shenhui. Mogrol regulates lipid metabolism in hepatocellular carcinoma HepG2 cells by activating AMPK signaling pathway [J]. Chinese Journal of tumor Biotherapy, 2019,26(08):876-881. |
(10α,24R)-3β,11α,24,25-Tetrahydroxy-9β-methyl-19-norlanosta-5-ene - Reference Information
| Plant Source: | momordica grosvenori |
| Overview | mogrol is the aglycone of the main chemical composition of Mogrosides, and Mogrosides are of Cucurbitaceae family. The mature fruit of momordica grosvenori is mainly produced in Yongfu, Lingui, Longsheng and other counties in Guangxi. It is a famous specialty of Guangxi. Momordica grosvenori is cool, sweet in taste, belongs to lung and large intestine, has the functions of moistening lung and relieving cough, clearing heat and relieving summer heat, relieving pharynx and opening sound, cooling blood and smoothing intestines. It is a unique economic crop of medicine and food homology in China, at the same time received in the Pharmacopoeia of the People's Republic of China, as commonly used in traditional Chinese medicine, in the treatment of pharyngitis, pertussis, acute and chronic bronchitis, gastrointestinal disease curative effect is remarkable. The total glycosides of momordica grosvenori is the main active ingredient of momordica grosvenori, which has a wide range of biological activity and pharmacological value. |
| effect | mogrol can obviously improve the space Cognitive Disorder and the decline of learning and memory function caused by senile dementia and ischemic brain dementia. Mogrol can increase the contents of inhibitory amino acids, glycine and γ-aminobutyric acid in the cerebral cortex of Alzheimer's disease rats, reduce the toxicity of excitatory glutamic acid, and can reduce the production of β-AP in the hippocampus of AD rats, for cerebral ischemia caused by the decline of learning and memory function also has a significant improvement. |
| preparation | 1) momordica grosvenori dried fruit 100g, crushed into very coarse powder, and extracted by adding 70% industrial ethanol for 3H, after filtration, ethanol was recovered from the filtrate (which can be used again for extraction of medicinal materials) to obtain 9.5g of alcohol extract. 2) take the alcohol extract, add 100ml of water to suspend, and then extract with 50ml of water volume of water-saturated ethyl acetate, separate the ethyl acetate layer, ethyl acetate (which can be used again for extraction) was recovered under reduced pressure to obtain 1.1g of ethyl acetate extract. 3) the aqueous solution after ethyl acetate extraction was added with a hydrochloric acid solution to a concentration of 5%. Then, 100ml of ethyl acetate was added thereto, and the mixture was heated under reflux for 8 hours. Cool to room temperature, separate the ethyl acetate solution, add NAOH solution to the ethyl acetate solution, adjust the pH to 7, separate the ethyl acetate layer, and recover the ethyl acetate under reduced pressure (can be used repeatedly), 1.9g of extract containing mogrol was obtained. 4) No. The extract containing mogrol was subjected to silica gel column chromatography (silica gel 300-400 mesh, dosage 95g;(column diameter 3.5, dry packed column, dry loading), and was eluted with chloroform, recover chloroform (can be used repeatedly), discard the chloroform eluate; 100ml chloroform-methanol (: 2) elution, flow rate of 5 ml/min, collect the eluate, decompression recovery solvent, crude demurosinol 1.2g. 5) the crude mogrol alcohol was recrystallized once with methanol, and the needle crystal of mogrol alcohol was 950mg, and the purity was 97.1%. |
| biological activity | Mogrol is a bio-metabolite of mogroside, which can inhibit ERK1/2 and STAT3 signaling pathway, at the same time, it can reduce the activity of CREB and activate AMPK. |
| Usage | activity of reversing tumor multidrug resistance. |
Last Update：2024-04-09 20:45:29
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Product Name: (10α,24R)-9β-Methyl-19-norlanosta-5-ene-3β,11α,24,25-tetrol Visit Supplier Webpage Request for quotationCAS: 88930-15-8
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: Mogrol Visit Supplier Webpage Request for quotationCAS: 88930-15-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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