(11beta)-11,21-dihydroxypregn-4-ene-3,20-dione
corticosterone
CAS: 50-22-6
Molecular Formula: C21H30O4
(11beta)-11,21-dihydroxypregn-4-ene-3,20-dione - Names and Identifiers
| Name | corticosterone |
| Synonyms | KENDALL'S 'B' corticosterone KENDALL'S COMPOUND B 21-Dihydroxyprogesterone 11,12-dihydroxyprogesterone 4-Pregnen-11?21-diol-3,20-dione 11BETA,21-DIHYDROXY-PROGESTERONE 11BETA,21-DIHYDROXY-4-PRENENE-3,20-DIONE 11BETA,21-DIHYDROXY-4-PREGNENE-3,20-DIONE 11-beta,21-dihydroxypregn-4-ene-3,20-dione (11BETA)-11,21-DIHYDROXYPREGN-4-ENE-3,20-DIONE (11beta)-11,21-dihydroxypregn-4-ene-3,20-dione |
| CAS | 50-22-6 |
| EINECS | 200-019-6 |
| InChI | InChI=1/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1 |
(11beta)-11,21-dihydroxypregn-4-ene-3,20-dione - Physico-chemical Properties
| Molecular Formula | C21H30O4 |
| Molar Mass | 346.47 |
| Density | 1.0413 (rough estimate) |
| Melting Point | 179-183°C(lit.) |
| Boling Point | 401.19°C (rough estimate) |
| Specific Rotation(α) | D15 +223° (c = 1.1 in alc) |
| Flash Point | 9℃ |
| Water Solubility | 240.5mg/L(37 ºC) |
| Solubility | Chloroform (Sparingly, Sonicated), Ethanol (Slightly, Sonicated), Methanol (Slig |
| Vapor Presure | 2.07E-13mmHg at 25°C |
| Appearance | White to tan crystalline powder |
| Color | White to Pale Yellow |
| Merck | 2538 |
| BRN | 2339601 |
| Storage Condition | -20°C |
| Stability | Stable, but light sensitive. Incompatible with strong oxidizing agents. |
| Refractive Index | 1.4430 (estimate) |
| In vitro study | Corticosterone phosphorylates the Ser-213 position of GDI through SGK, increases the formation of GDI-Rab4 complexes, and promotes the operation of Rab4 and Rab4 mediated AMPARs to synaptic membrane cycle. It is able to enhance the amplitude of AMPAR-mediated tiny excitatory postsynaptic currents (mEPSC) and the cell surface expression of GluR1 and GluR2 in hippocampal neurons, increase its surface mobility and the content of AMPAR GluR2 subunit in synapses, and enhance L-type calcium currents in CA1 vertebral neurons. Corticosterone works through mineralocorticoid receptor and glucocorticoid receptor, both of which belong to nuclear receptors and bind to response elements on DNA, it regulates and modifies the expression activity of related genes. |
| In vivo study | Corticosterone plays an important role in regulating neuronal function in the limbic system. After stress, levels of stress hormones such as corticosterone rise sharply. Corticosterone exerts a time-dependent and region-specific role in the cell physiology of limbic neurons. |
(11beta)-11,21-dihydroxypregn-4-ene-3,20-dione - Risk and Safety
| Risk Codes | R43 - May cause sensitization by skin contact R40 - Limited evidence of a carcinogenic effect R39/23/24/25 - R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
| Safety Description | S36 - Wear suitable protective clothing. S22 - Do not breathe dust. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S16 - Keep away from sources of ignition. |
| UN IDs | UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany | 3 |
| RTECS | GM7650000 |
| HS Code | 29372900 |
| Toxicity | An adrenocortical steroid with modest glucocorticoid and mineralocorticoid activity. It is the primary glucocorticoid in the rat. |
(11beta)-11,21-dihydroxypregn-4-ene-3,20-dione - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Biological activity | Corticosterone (17-deoxycortisol, 11 β,21-dihydroxyprogesterone) is the main stress hormone, an adrenal corticosteroid, which has the activity as mineralocorticoid and glucocorticoid. |
| Target | Value |
| production method | can be separated from adrenal gland extract, or can be prepared from bile acid, yam saponin, etc. |
Last Update：2024-04-10 22:41:30
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