(13β)-1,19-Didehydro-2α,3β,4β,7-tetrahydroxy-11,12-dinor-5,19-secocrinan-6-one
Narciclasine
CAS: 29477-83-6
Molecular Formula: C14H13NO7
(13β)-1,19-Didehydro-2α,3β,4β,7-tetrahydroxy-11,12-dinor-5,19-secocrinan-6-one - Names and Identifiers
(13β)-1,19-Didehydro-2α,3β,4β,7-tetrahydroxy-11,12-dinor-5,19-secocrinan-6-one - Physico-chemical Properties
| Molecular Formula | C14H13NO7 |
| Molar Mass | 307.26 |
| Density | 1.85±0.1 g/cm3 (20 ºC 760 Torr) |
| Melting Point | 250-252℃ |
| Boling Point | 447.77°C (rough estimate) |
| Specific Rotation(α) | +145 (c, 1.5 in EtOH) |
| Solubility | Soluble in methanol, DMSO |
| Appearance | White crystal or powder |
| Color | white to off-white |
| pKa | 7.72±0.70(Predicted) |
| Storage Condition | Store at -20°C |
| Refractive Index | 1.5300 (estimate) |
| MDL | MFCD01729949 |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from narcissus. |
| In vitro study | Narciclasine activates Rho and stress fibers in glioblastoma multiforme cells. The mean IC 50 of ~50 nM calculated on the 6 human glioblastoma multiforme (U373, Hs683, GL19, GL5, GL16, GL17), The mean IC 50 value of 47 nM for Narciclasine across a panel of 60 cancer cell lines. Bioassay-guided fractionation of the A. belladonna extract resulted in the identification of lycorine as the bio-active compound. The IC 50 measured for radicle growth inhibition is 0.1 µM for Narciclasine. |
| In vivo study | The i.v. regimen of Narciclasine at 1 mg/kg significantly (P=0.02) increases the survival of GL19 glioblastoma multiforme-bearing mice. Narciclasine when given orally at the same dose five times a week for 5 consecutive weeks also significantly increases animal survival in this model (P=0.008). Oral treatment with Narciclasine at 1 mg/kg significantly increases the survival (P=0.004) of Hs683 glioblastoma multiforme-bearing mice. Increasing the number of doses administered per week does not increase the survival of these Hs683 glioblastoma multiforme-bearing mice. Narciclasine appears to show similar increased survival in these models to temozolomide but at appreciable lower doses and following both oral and i.v. administration. |
(13β)-1,19-Didehydro-2α,3β,4β,7-tetrahydroxy-11,12-dinor-5,19-secocrinan-6-one - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 46 - May cause heritable genetic damage |
| Safety Description | 36 - Wear suitable protective clothing. |
(13β)-1,19-Didehydro-2α,3β,4β,7-tetrahydroxy-11,12-dinor-5,19-secocrinan-6-one - Reference
| Reference Show more | 1. [IF=5.491] Jiayu Zhou et al."Fungal endophytes promote the accumulation of Amaryllidaceae alkaloids in Lycoris radiata."Environ Microbiol. 2020 Apr;22(4):1421-1434 |
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Product Name: Narciclasine Visit Supplier Webpage Request for quotationCAS: 29477-83-6
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Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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